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    Antibacterial penem derivatives
    82.
    发明公开
    Antibacterial penem derivatives 失效
    抗菌青霉烯衍生物

    公开(公告)号：EP0069377A3

    公开(公告)日：1983-04-13

    申请号：EP82105989

    申请日：1982-07-05

    申请人： HOECHST UK LIMITED

    发明人： Cooke, Michael David ,  Ross, Barry Clive

    IPC分类号： C07D499/00 ,  C07D205/08 ,  A61K31/43 ,  C07F07/18 ,  C07D333/38 ,  C07D409/12

    CPC分类号： C07D205/08 ,  C07D205/09 ,  C07D333/38 ,  C07D499/88 ,  C07F7/186

    摘要： Penem derivative of the formula 1
    in which
    R is hydrogen or a carboxyl esterifying group, R 1 is phenyl, napthyl, thienyl, pyridyl, quinolyl or isoquinolyl being unsubstituted or substituted by one, two or three of the same or different substituents selected from halogen, hydroxy, amino, nitro, cyano, azido, alkyl, alkoxy, alkanesulfenyl, alkanesulfinyl, alkanesulfonyl, alkanoyl, alkoxycarbonyl, alkanoyloxy, carbamoyl, ureido, carba- moyloxy, alkanoylamino, aminosulfamoyl, sulfamoyl, guani- dino, trifluormethyl, trifluormethanesulfenyl, trifluor- methanesulfinyl, trifluormethanesulfonoyl and formyl, which may be substituted by one, two or three lower alkyl groups being the same or different. R 2 represents a hydrogen atom or a optionally protected hydroxyl group, or a salt thereof,
    process for the production thereof and antibacterial pharmaceutical preparations comprising them.

    摘要翻译： 其中R为氢或羧基酯化基团的式1的青霉烯衍生物，R 1为未取代的苯基，萘基，噻吩基，吡啶基，喹啉基或异喹啉基或被1,2或3个相同或不同的选自卤素， 羟基，氨基，硝基，氰基，叠氮基，烷基，烷氧基，烷烃亚磺酰基，烷烃亚磺酰基，烷磺酰基，烷酰基，烷氧基羰基，烷酰氧基，氨基甲酰基，脲基， 甲磺酰基，三氟甲磺酰基和甲酰基，它们可以被一个，两个或三个低级烷基相同或不同。 R2代表氢原子或任选保护的羟基，或其盐，其制备方法和包含它们的抗菌药物制剂。