公开(公告)号：EP2178823A1

公开(公告)日：2010-04-28

申请号：EP08786374.2

申请日：2008-07-24

申请人： Glaxo Group Limited

发明人： CASTIGLIONI, Emiliano ,  DI FABIO, Romano ,  GIANOTTI, Massimo ,  MESIC, Milan ,  PAVONE, Francesca ,  RAST, Slavko ,  STASI, Luigi, Piero

IPC分类号： C07C211/38 ,  A61K31/131 ,  A61P25/00

CPC分类号： C07C211/38 ,  C07C2603/94

摘要： This invention relates to novel spiro cyclopentane derivatives of formula (I) or a pharmaceutically acceptable salt thereof, for treating diseases and conditions of the central nervous system (CNS), in particular sleep disorders.

摘要翻译： 本发明涉及式（I）的新型螺环戊烷衍生物或其药学上可接受的盐，用于治疗中枢神经系统（CNS）的疾病和病症，特别是睡眠障碍。

公开(公告)号：EP2170807A1

公开(公告)日：2010-04-07

申请号：EP08786375.9

申请日：2008-07-24

申请人： Glaxo Group Limited

发明人： BOTTA, Maurizio ,  CASTIGLIONI, Emiliano ,  DI FABIO, Romano ,  SPINOSA, Raffaella ,  TOGNINELLI, Andrea

IPC分类号： C07C211/38 ,  C07D498/10 ,  C07D491/10 ,  C07D295/02 ,  C07D205/04 ,  A61K31/131 ,  A61P25/00

CPC分类号： C07C211/42 ,  C07C2603/94 ,  C07D221/20 ,  C07D295/00 ,  C07D295/027 ,  C07D295/03 ,  C07D295/033 ,  C07D491/10 ,  C07D498/10

摘要： The invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, for treating diseases and conditions of the central nervous system (CNS), in particular sleep disorders.

摘要翻译： 本发明提供了用于治疗中枢神经系统（CNS）的疾病和病症的式（I）化合物或其药学上可接受的盐，特别是睡眠障碍。

公开(公告)号：EP2170806A1

公开(公告)日：2010-04-07

申请号：EP08776227.4

申请日：2008-07-18

申请人： Generics [UK] Limited

发明人： JOHNSTON, Lynsey ,  LEE, Nick ,  WOJTACHNIO-ZAWADA, Kataryzna ,  DUNCAN, David ,  CAMPBELL, John ,  DOYLE, Tracy

IPC分类号： C07C209/84 ,  C07C211/38 ,  G01N30/88

CPC分类号： C07C209/84 ,  C07C2603/74 ,  G01N30/06 ,  G01N30/14 ,  G01N2030/025 ,  C07C211/38

摘要： The present invention relates to a novel assay for the analysis of memantine and related compounds.

摘要翻译： 本发明涉及一种用于分析美金刚及相关化合物的新型测定方法。

公开(公告)号：EP1674446A4

公开(公告)日：2009-09-09

申请号：EP03785457

申请日：2003-12-19

申请人： SHANGHAI INST PHARM INDUSTRY ,  ZHEJIANG KANGYU PHARMACEUTICAL

发明人： ZHANG FULI ,  HU MENG ,  ZHAO LIZHI ,  GE MENGYA

IPC分类号： C07C211/38 ,  A61P25/28 ,  C07C209/08

CPC分类号： C07C209/08 ,  C07C211/38

摘要： A new method of preparing memantine hydrochloride, comprises the following steps: reacting 1-bromo-3, 5-dimethyl adamantane and urea/formic acid with formic acid also acting as the solvent; hydrolysising with aqueous inorganic acid; alkalifying, extracting and acidifying with hydrochloric acid; finally collecting target compound. The method uses cheaper raw materials and conducts in homogeneous phase under mild conditions. It can reach high yield and good product purity, and be suitable for macrochemistry. The purity of crude product is 99.0%, and reaches 99.98% after first recrystallization, yield: 69.5%, bp: 332ºC (DSC).

公开(公告)号：EP1664020A1

公开(公告)日：2006-06-07

申请号：EP04775365.2

申请日：2004-09-01

申请人： AstraZeneca AB

发明人： DAHLSTRÖM, Mikael ,  LINDQVIST, Bo

IPC分类号： C07D401/12 ,  A61K31/4439 ,  C07C211/38 ,  A61P1/04

CPC分类号： C04B35/632 ,  C07D401/12

摘要： The present invention relates to new salts of the single enantiomers of omeprazole, i.e. salts of (S)-5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methyl]sulfinyl]-1H-benzimidazole ((S)-omeprazole) and (R)-5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methyl]sulfinyl]-1H-benzimidazole ((R)-omeprazole) respectively. More specifically, the present invention relates to 1-cyclohexylethyl ammonium salts of the compounds, formed by a reaction of (S)-omeprazole and (R)-omeprazole respectively and 1-cyclohexylethyl amine. The present invention also relates to a process for preparing the compounds of the invention, a pharmaceutical preparation and a method for treatment of gastric related disorders by administering the compounds of the invention.

摘要翻译： （S）-5-甲氧基-2 - [[（4-甲氧基-3,5-二甲基-2-吡啶基） - 甲基]亚磺酰基] - 的盐的奥美拉唑的单一对映异构体的新盐， （（S） - 奥美拉唑）和（R）-5-甲氧基-2 - [[（4-甲氧基-3,5-二甲基-2-吡啶基） - 甲基]亚磺酰基] -1H-苯并咪唑 ） - 奥美拉唑）。 更具体地说，本发明涉及由（S） - 奥美拉唑和（R） - 奥美拉唑分别与1-环己基乙基胺反应形成的化合物的1-环己基乙基铵盐。 本发明还涉及制备本发明化合物的方法，药物制剂和通过施用本发明化合物治疗胃相关病症的方法。

公开(公告)号：EP1664019A1

公开(公告)日：2006-06-07

申请号：EP04775364.5

申请日：2004-09-01

申请人： AstraZeneca AB

发明人： DAHLSTRÖM, Mikael ,  BRÄNDSTRÖM, Arne

IPC分类号： C07D401/12 ,  A61K31/4439 ,  C07C211/38 ,  A61P1/04

CPC分类号： C04B35/632 ,  C07C211/38 ,  C07C2603/74 ,  C07D401/12

摘要： The present invention relates to new salts of omeprazole and esomeprazole respectively, i.e. salts of 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methyl]sulfinyl]-1H-benzimidazole and the (S)-enantiomer thereof. More specifically, the present invention relates to adamantan ammonium salt of the compounds, formed by a reaction of omeprazole and esomeprazole respectively and adamantan amine. The present invention also relates to a process for preparing the compounds of the invention, a pharmaceutical preparation and a method for treatment of gastric related disorders by administering the compounds of the invention.

摘要翻译： 本发明分别涉及奥美拉唑和艾美拉唑的新盐，即5-甲氧基-2 - [[（4-甲氧基-3,5-二甲基-2-吡啶基） - 甲基]亚磺酰基] -1H-苯并咪唑的盐和 （S） - 对映异构体。 更具体地，本发明涉及通过奥美拉唑和埃索美拉唑与金刚烷胺的反应形成的化合物的金刚烷铵盐。 本发明还涉及通过给予本发明化合物来制备本发明化合物的方法，药物制剂和治疗胃相关疾病的方法。

公开(公告)号：EP1403244A3

公开(公告)日：2004-08-04

申请号：EP03020588.4

申请日：2003-09-18

申请人： Mitsubishi Gas Chemical Company, Inc.

发明人： Koyama, Takeshi, Hiratsuki Research Lab. ,  Ichikawa, Tetsushi, Hiratsuki Research Lab. ,  Kuwahara, Hisayuki, Hiratsuki Research Lab. ,  Echigo, Masatoshi, Hiratsuki Research Lab.

IPC分类号： C07C211/36 ,  C07C211/38 ,  C08G59/50

CPC分类号： C07C211/36 ,  C07C211/38 ,  C07C2601/14 ,  C07C2602/42

摘要： An object of the present invention is to provide a modified cyclic aliphatic polyamine having a low viscosity and a small content of unreacted polyamine which can provide, when it is used as a curing agent for epoxy resin, an epoxy resin composition having an improved workability without adding solvent or diluent and an excellent property of epoxy resin cure product. The above modified cyclic aliphatic polyamine is obtained by addition reaction of a cyclic aliphatic polyamine such as isophoronediamine and norbornanediamine and an alkenyl compound such as styrene. The modified cyclic aliphatic polyamine thus obtained is added in epoxy resin to be used as a curing agent for epoxy resin.

摘要翻译： 本发明的一个目的是提供一种改性的具有低粘度和少量未反应多胺的环状脂肪族多胺，当它用作环氧树脂的固化剂时，可以提供具有改进的可加工性的环氧树脂组合物， 加入溶剂或稀释剂以及环氧树脂固化产品的优异性能。 上述改性环状脂肪族多元胺通过异佛尔酮二胺，降冰​​片烷二胺等环状脂肪族多胺与苯乙烯等链烯基化合物的加成反应而得到。 将这样得到的改性环状脂肪族多胺添加到环氧树脂中，作为环氧树脂的固化剂使用。

公开(公告)号：EP1403244A2

公开(公告)日：2004-03-31

申请号：EP03020588.4

申请日：2003-09-18

申请人： Mitsubishi Gas Chemical Company, Inc.

发明人： Koyama, Takeshi, Hiratsuki Research Lab. ,  Ichikawa, Tetsushi, Hiratsuki Research Lab. ,  Kuwahara, Hisayuki, Hiratsuki Research Lab. ,  Echigo, Masatoshi, Hiratsuki Research Lab.

IPC分类号： C07C211/36 ,  C07C211/38 ,  C08G59/50

CPC分类号： C07C211/36 ,  C07C211/38 ,  C07C2601/14 ,  C07C2602/42

摘要： An object of the present invention is to provide a modified cyclic aliphatic polyamine having a low viscosity and a small content of unreacted polyamine which can provide, when it is used as a curing agent for epoxy resin, an epoxy resin composition having an improved workability without adding solvent or diluent and an excellent property of epoxy resin cure product. The above modified cyclic aliphatic polyamine is obtained by addition reaction of a cyclic aliphatic polyamine such as isophoronediamine and norbornanediamine and an alkenyl compound such as styrene. The modified cyclic aliphatic polyamine thus obtained is added in epoxy resin to be used as a curing agent for epoxy resin.

摘要翻译： 本发明的目的是提供一种具有低粘度和少量未反应的多胺的改性环脂族多胺，当其用作环氧树脂的固化剂时，可以提供具有改善的可加工性的环氧树脂组合物，而没有 添加溶剂或稀释剂，并具有优异的环氧树脂固化产品性能。 上述改性环状脂肪族聚胺通过环状脂肪族多胺如异佛尔酮二胺和降冰片二胺与链烯基化合物如苯乙烯的加成反应得到。 将这样得到的改性环状脂肪族聚胺加入到环氧树脂中，用作环氧树脂的固化剂。

公开(公告)号：EP0718281A4

公开(公告)日：1997-11-26

申请号：EP94926366

申请日：1994-09-07

申请人： NISSIN FOOD PRODUCTS LTD

发明人： YAMADA TOSHIHIRO ,  NOBUHARA YOICHI ,  TAKAGI ICHINARI ,  FURUMOTO SHIHO ,  KOBAYASHI KAZUHIRO ,  IKEMOTO KIYOHITO

IPC分类号： A61K31/17 ,  A61K31/34 ,  A61K31/341 ,  A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61K31/44 ,  A61K31/445 ,  A61K31/451 ,  A61K31/47 ,  A61K31/472 ,  A61P3/06 ,  A61P9/10 ,  C07C211/18 ,  C07C211/27 ,  C07C211/38 ,  C07C275/28 ,  C07C275/40 ,  C07D209/04 ,  C07D209/40 ,  C07D211/26 ,  C07D213/75 ,  C07D215/38 ,  C07D217/22 ,  C07D233/54 ,  C07D307/52 ,  C12N9/99 ,  C07D213/72

CPC分类号： C07D233/64 ,  C07C211/18 ,  C07C211/27 ,  C07C275/40 ,  C07C2601/14 ,  C07C2601/16 ,  C07C2601/18 ,  C07C2602/42 ,  C07C2603/74 ,  C07D209/40 ,  C07D215/38 ,  C07D307/52

摘要： A cyclohexanediurea derivative represented by general formula (I) or a salt thereof, a process for producing the same, an intermediate therefor, medicinal applications thereof, method of treatment therewith, and use thereof, wherein R?1 and R2¿ represent each independently at least C¿3? linear or branched alkyl, cycloalkyl which may have a bridgehead atom, furyl, furyl-substituted lower alkyl, or aralkyl; and A1 and A2 represent each independently optionally substituted phenyl, pyridyl, quinolyl, isoquinolyl or indolyl.

公开(公告)号：EP0547499B1

公开(公告)日：1996-03-27

申请号：EP92121029.0

申请日：1992-12-10

申请人： HOECHST AKTIENGESELLSCHAFT

发明人： Kniep, Claus ,  Kampmann, Detlef, Dr. Dipl.-Chem. ,  Weber, Jürgen, Dr. Dipl.-Chem-

IPC分类号： C07C211/38 ,  C07C209/26

CPC分类号： C07C209/26 ,  C07C211/38 ,  C07C2603/68