公开(公告)号：EP1048649A4

公开(公告)日：2001-03-21

申请号：EP98961615

申请日：1998-12-25

申请人： NISSIN FOOD PRODUCTS LTD

发明人： YAMADA TOSHIHIRO ,  NOBUHARA YOICHI ,  KOBAYASHI KAZUHIRO ,  HIRANO SATOSHI ,  SAKURAI TAKANOBU ,  MIKAMI HIROSHI ,  MIYAKE AYAKO

IPC分类号： A61P29/02 ,  C07D207/32 ,  C07D207/333 ,  C07D207/30 ,  A61K31/40 ,  C07D403/04 ,  C07D405/04

CPC分类号： C07D207/333

摘要： Compounds represented by general formula (I) or salts thereof and anti-inflammatory agents and antitumor agents containing these compounds as the active ingredient, wherein R1 represents hydrogen or lower alkyl; R2 represents lower alkyl or (CH¿2?)n1 COOH (wherein n1 is 1, 2 or 3); R?3¿ represents hydrogen, halogeno, carboxy, etc.; R4 represents phenyl optionally having a specific substituent, dicyclic heteroaryl, phenylethynyl or lower alkynyl; and R5 represents lower alkyl, amino, etc.

公开(公告)号：EP0718281A4

公开(公告)日：1997-11-26

申请号：EP94926366

申请日：1994-09-07

申请人： NISSIN FOOD PRODUCTS LTD

发明人： YAMADA TOSHIHIRO ,  NOBUHARA YOICHI ,  TAKAGI ICHINARI ,  FURUMOTO SHIHO ,  KOBAYASHI KAZUHIRO ,  IKEMOTO KIYOHITO

IPC分类号： A61K31/17 ,  A61K31/34 ,  A61K31/341 ,  A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61K31/44 ,  A61K31/445 ,  A61K31/451 ,  A61K31/47 ,  A61K31/472 ,  A61P3/06 ,  A61P9/10 ,  C07C211/18 ,  C07C211/27 ,  C07C211/38 ,  C07C275/28 ,  C07C275/40 ,  C07D209/04 ,  C07D209/40 ,  C07D211/26 ,  C07D213/75 ,  C07D215/38 ,  C07D217/22 ,  C07D233/54 ,  C07D307/52 ,  C12N9/99 ,  C07D213/72

CPC分类号： C07D233/64 ,  C07C211/18 ,  C07C211/27 ,  C07C275/40 ,  C07C2601/14 ,  C07C2601/16 ,  C07C2601/18 ,  C07C2602/42 ,  C07C2603/74 ,  C07D209/40 ,  C07D215/38 ,  C07D307/52

摘要： A cyclohexanediurea derivative represented by general formula (I) or a salt thereof, a process for producing the same, an intermediate therefor, medicinal applications thereof, method of treatment therewith, and use thereof, wherein R?1 and R2¿ represent each independently at least C¿3? linear or branched alkyl, cycloalkyl which may have a bridgehead atom, furyl, furyl-substituted lower alkyl, or aralkyl; and A1 and A2 represent each independently optionally substituted phenyl, pyridyl, quinolyl, isoquinolyl or indolyl.