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公开(公告)号：EP1817274B1
公开(公告)日：2009-03-18
申请号：EP05816199.3
申请日：2005-11-29
发明人： MÖLLER, Roland , GOMEZ, Mario , EINMAYR, Klaus , HILDEBRAND, Jens , ERBEN, Hans-Georg , KRIMMER, Hans-Peter
IPC分类号： C07C253/22 , C07C253/34 , C07C255/53
CPC分类号： C07C253/22 , C07C253/34 , Y02P20/127 , C07C255/53
摘要： The invention relates to a method for producing amino- or hydroxybenzonitriles during which, within the scope of an ammonolysis, the corresponding amino- or hydroxybenzoic acid compounds are reacted with ammonia in the presence of a phosphate-containing supported catalyst at temperatures between 250 °C and 500 °C. The actual production step is carried out in a reaction gas (mixture) and without the involvement of an organic solvent and is followed by an at least 2-stage purification step. Firstly, the gaseous mixture obtained from the production step is converted into an aqueous basic suspension, and the product contained in the solid matter is subsequently released from this suspension. The main advantage of this combined method is that it does not start by using esters which is why the obtained products, in contrast to conventional methods, are free of the otherwise usual by-products whereby leading to a high product purity. In addition, the claimed method can be carried out in the utmost economical manner since the final product and the by-products in the used suspension exist in different states of aggregation and, therefore, can be easily separated from one another. This makes it possible to obtain solvent-free benzonitriles, which contain amino or hydroxy groups, with a high yield and with a distinctly improved product quality.
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82.发明公开VERFAHREN ZUR ISOLIERUNG VON METHYLGLYCINNITRIL-N,N-DIACETONITRILEN AUS EINEM WÄSSRIGEN ROHGEMISCH 有权METHOD FOR ISOLATING methylglycinenitrile-N，N-DIACETONITRILEN从含水粗
公开(公告)号：EP1883623A1
公开(公告)日：2008-02-06
申请号：EP06754975.8
申请日：2006-05-03
发明人： OFTRING, Alfred , JUDAT, Bernd , RAULS, Matthias , FRIESE, Katrin
IPC分类号： C07C253/34 , C07C255/24 , C07C255/25
CPC分类号： C07C253/34 , C07C255/24 , C07C255/25
摘要： The invention relates to a method for isolating methyl glycine nitrile-N,N-diacetonitriles (MGDN) from an MGDN-containing aqueous emulsion with an MGDN content of 3 - 50% by weight in a crystallizer. The inventive method is characterized by (a) cooling the aqueous emulsion, starting from a temperature above the solidification point, to a temperature below the solidification point, the cooling rate in the temporal mean not exceeding 5 K/h, until substantially the total amount of the emulsified MGDN has solidified; and (b) continuing to cool the aqueous suspension obtained and/or concentrating it, the cooling rate being higher than that in step (a).
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83.发明公开PROCESS FOR REMOVAL OF ACROLEIN FROM ACRYLONITRILE PRODUCT STREAMS 审中-公开VERFAHREN ZUR ENTFERNUNG VON ACROLEIN AUSACRYLONITRILPRODUKTSTRÖMEN
公开(公告)号：EP1638911A4
公开(公告)日：2007-02-21
申请号：EP04755779
申请日：2004-06-21
申请人： SOLUTIA INC
发明人： WARD GREGORY J , BLANCHARD BRYAN , MOFFATT SCOTT G , MONICAL VALERIE S , MURPHY RICHARD D , RAMCHANDRAN BALSHEKAR
IPC分类号： C07C43/32 , C07C45/85 , C07C51/487 , C07C253/34 , C07C255/08
CPC分类号： C07C45/85 , C07C51/487 , C07C253/34 , C07C47/22 , C07C57/04 , C07C255/08
摘要： Acrolein is removed from a process stream such as a process stream generated in the manufacture of acrylonitrile. The process includes reacting the acrolein with a compound containing a reactable thiol or hydroxyl moiety in the presence of an acid catalyst. The present process provides for a refined process stream that contains no more than 5 ppm by weight unreacted acrolein.
摘要翻译： 丙烯醛从工艺物流中除去，例如丙烯腈生产中产生的工艺物流。 该方法包括在酸催化剂存在下使丙烯醛与含有可反应的硫醇或羟基部分的化合物反应。 本发明方法提供了含有不超过5重量ppm未反应丙烯醛的精制工艺流。
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84.发明公开METHOD FOR THE SEPARATION OF INTERMEDIATES WHICH MAY BE USED FOR THE PREPARATION OF ESCITALOPRAM 有权用于分离的中间体，以产生艾司西酞普兰中使用
公开(公告)号：EP1716108A1
公开(公告)日：2006-11-02
申请号：EP05700625.6
申请日：2005-02-02
申请人： H. LUNDBECK A/S
发明人： LYNGSO, Lars Ole
IPC分类号： C07C253/34 , C07C253/30 , C07C255/59 , C07D307/87
CPC分类号： C07C253/30 , C07B2200/07 , C07C253/34 , C07D307/87 , C07C255/53 , C07C255/59
摘要： The invention relates to a method of separating and isolating an acylated derivative of 4-[(S)-4-dimethylamino-1-(4-fluorophenyl)-1-hydroxybutyl]-3-hydroxymethylbenzonitrile by reaction of a mixture of the 4-[(S)-4-dimethylamino-1-(4-fluorophenyl)-1-hydroxy-butyl]-3-hydroxymethylbenzonitrile and an acylated derivative thereof with a compound which form a derivative of the 4-[(S)-4-dimethylamino-1-(4-fluorophenyl)-1-hydroxy-butyl]-3-hydroxymethylbenzonitrile containing a carboxylic acid group. The acylated derivative containing a carboxylic acid group precipitates once it is formed and may easily be separated from the reaction mixture.
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85.发明公开METHOD FOR PRODUCING PURIFIED 2-CYANOACRYLATE 有权VERFAHREN ZUR HERSTELLUNG VON AUFGEREINIGTEM 2-CYANOACRYLAT
公开(公告)号：EP1632478A1
公开(公告)日：2006-03-08
申请号：EP04735131.7
申请日：2004-05-27
申请人： TOAGOSEI CO., LTD.
IPC分类号： C07C253/34 , C07C255/23
CPC分类号： C07C253/34 , C07C255/23
摘要： A method for producing a purified 2-cyanoacrylate is characterized in that distillation is conducted in the presence of a polymerization inhibitor whose boiling point is within ±12°C of the boiling point of the 2-cyanoacrylate. With this method, polymerization of 2-cyanoacrylate can be continuously prevented in the distillate system during distillation of a crude 2-cyanoacrylate, so that a purified 2-cyanoacrylate can be obtained.
摘要翻译： 一种纯化的2-氰基丙烯酸酯的制备方法的特征在于在聚合抑制剂的存在下进行蒸馏，该聚合抑制剂的沸点在2-氰基丙烯酸酯的沸点±12℃以内。 通过这种方法，可以在馏出2-氰基丙烯酸酯的蒸馏过程中在馏出物体系中连续地防止2-氰基丙烯酸酯的聚合，从而可以获得纯化的2-氰基丙烯酸酯。
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公开(公告)号：EP1560808A2
公开(公告)日：2005-08-10
申请号：EP03799464.7
申请日：2003-11-13
申请人： Akzo Nobel N.V.
IPC分类号： C07C253/34
CPC分类号： C07C253/34 , C07C255/03 , C07C255/07
摘要： The present invention contemplates a process for the removal of impurities comprising amides, but which may include other impurities such as amines, from a solution of the nitrites and impurities. A reaction mixture is first formed and to that reaction mixture, 0.5 to 3wt% of approximately 60% H2SO4 is stirred in at room temperature and atmospheric pressure for a time effective for the removal of the amide impurities. Typically, after about 30 minutes, the amide impurity is removed into the lower, dark acid layer, probably as a salt. The remaining nitrile, after decantation or filtration, is still colored but is substantially free of amide. In a to second step, at room temperature or at a temperature of up to ~80°C, color can be removed from the nitrile by stirring the acid-washed nitrile with 0.5-5 wt% of clay (bentonite), charcoal, zeolitic type materials, mixtures thereof and the like.
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87.发明公开VERFAHREN ZUR REDUZIERUNG DES GEHALTS AN EINEM UNGES TTIGTEN AMIN IN EINER MISCHUNG ENTHALTEND EIN AMINONITRIL, EIN DIAMIN, EIN DINITRIL ODER DEREN GEMISCHE 有权一种用于减少的不饱和胺的含量在混合物中含有氨基腈，二胺，二腈或它们的混合物
公开(公告)号：EP1511720A1
公开(公告)日：2005-03-09
申请号：EP03755046.4
申请日：2003-05-21
发明人： MAIXNER, Stefan , BENISCH, Christoph , LUYKEN, Hermann , BA LER, Peter , FISCHER, Rolf-Hartmuth , MELDER, Johann-Peter , ANSMANN, Andreas
IPC分类号： C07C253/34 , C07C209/84
CPC分类号： C07C253/34 , C07C255/24
摘要： The invention relates to a method for reducing the content of an aliphatic, monounsaturated amine (IV) in a mixture (V) containing an aminonitrile (I) or a diamine (II) or a dinitrile (III) or mixtures thereof and amine (IV), whereby: a) mixture (V) is reacted with an anionic nucleophile (VI) in a quantity ranging from 0.01 to 10 mols per mol of amine (IV) in mixture (V) at a temperature ranging from 50 to 200 °C while obtaining mixture (VII), and; b) amino nitrile (I) or diamine (II) or dinitrile (III) or mixtures thereof are removed by distillation from mixture (VII) at a temperature ranging from 50 to 200 °C and under a pressure ranging from 0.1 to 100 kPa while obtaining a bottom product (VIII). The inventive method is characterized in that: c) an amino nitrile (I) or diamine (II) or dinitrile (III) or mixtures thereof are removed by distillation from bottom product (VIII) at a temperature which is lower than that selected in step b).
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公开(公告)号：EP1506161A1
公开(公告)日：2005-02-16
申请号：EP03730322.9
申请日：2003-05-21
IPC分类号： C07C253/14 , C07C253/34 , C07C255/20
CPC分类号： C07C253/34 , C07C253/14 , C07C255/20
摘要： The present invention relates to a continuous process for the cyanation of hydrogenated β-ketoesters in a cyanation zone maintained under conditions of temperature and pressure effective for cyanation of a hydrogenated R-ketoester. A substrate comprising a hydrogenated β-ketoester is continuously supplyed to the cyanation zone together with a cyanide. The substrate is contacted with the cyanide in the cyanation zone for a period effective for at least partial cyanation of the hydrogenated β-ketoester and a product stream is continuously extracted from the cyanation zone.
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公开(公告)号：EP1171421B1
公开(公告)日：2004-09-29
申请号：EP00919615.5
申请日：2000-03-24
发明人： HYATT, John, A.
IPC分类号： C07C253/14 , C07C253/34
CPC分类号： C07C253/34 , C07C253/14 , C07C2601/02 , C07C255/31
摘要： Disclosed is a process for the preparation and recovery of cyclopropylacetonitrile by a novel combination of process steps beginning with a mixture of cyclopropylmethyl halide, a cyclobutyl halide and a 4-halo-1-butene. The process permits the recovery of substantially pure cyclopropylacetonitrile and cyclobutyl halide, e.g., cyclopropylacetonitrile and cyclobutyl halide each having a purity greater than 95 %.
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90.发明授权Process for recovery and recycle of ammonia from an acrylonitrile reactor effluent stream using an ammonium phosphate quench system 失效一种用于从Acrylonitrilreaktors的废物流中回收氨的方法是指Ammoniumphosphatabkühlsystems的
公开(公告)号：EP0885843B1
公开(公告)日：2004-04-28
申请号：EP97304242.7
申请日：1997-06-17
IPC分类号： C01C1/12 , C07C253/24 , C07C253/34
CPC分类号： C07C253/24 , C01C1/12 , C07C255/08
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