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    IMPROVED METHOD FOR PRODUCTION OF STABLE CERIUM OXIDE ORGANIC COLLOIDS
    6.
    发明授权
    IMPROVED METHOD FOR PRODUCTION OF STABLE CERIUM OXIDE ORGANIC COLLOIDS 有权
    改进的生产稳定氧化铈有机胶体的方法

    公开(公告)号：EP2809437B1

    公开(公告)日：2018-03-28

    申请号：EP13704313.9

    申请日：2013-01-30

    申请人： Cerion LLC

    发明人： PROK, Gary, Robert ,  WILLIAMS, Stephen, Charles

    IPC分类号： B01J13/00

    CPC分类号： B01J13/0047 ,  B01J13/003

    摘要： An improved process for producing substantially non-polar doped or un-doped cerium oxide nanoparticle dispersions is disclosed. The cerium-containing oxide nanoparticles of an aqueous colloid are transferred to a substantially non-polar liquid comprising one or more amphiphilic materials, one or more low-polarity solvents, and one or more glycol ether promoter materials. The transfer is achieved by mixing the aqueous and substantially non-polar materials, forming an emulsion, followed by a phase separation into a remnant polar solution phase and a substantially non-polar organic colloid phase. The organic colloid phase is then collected. The promoter functions to speed the transfer of nanoparticles to the low-polarity phase. The promoter accelerates the phase separation, and also provides improved colloidal stability of the final substantially non-polar colloidal dispersion. Importantly, the glycol ether promoter reduces the temperature necessary to achieve the phase separation, while providing high extraction yield of nanoparticles into the low-polarity organic phase.

    COBALT OXIDE NANOPARTICLE PREPARATION
    7.
    发明公开
    COBALT OXIDE NANOPARTICLE PREPARATION 审中-公开
    氧化钴纳米颗粒制备

    公开(公告)号：EP3245160A1

    公开(公告)日：2017-11-22

    申请号：EP16701707.8

    申请日：2016-01-12

    申请人： Cerion LLC

    发明人： SANDFORD, David, Wallace

    IPC分类号： C01G51/04

    CPC分类号： C01G51/04 ,  B01J23/75 ,  B01J35/0013 ,  B01J37/04 ,  C01P2002/32 ,  C01P2002/60 ,  C01P2002/72 ,  C01P2004/64

    摘要： A method of making stable aqueous dispersions and concentrates of cobalt oxide nanoparticles is described, wherein a reaction mixture comprising cobalt(II) ion, a carboxylic acid, a base, an oxidant and water is formed, and in which cobalt oxide nanoparticles are formed. Cobalt oxide nanoparticles ranging in average crystallite size from about 4 nm to 15 nm are described. The cobalt oxide nanoparticles may be isolated and redispersed to form stable, homogeneous, aqueous dispersions of cobalt oxide nanoparticles containing from about 1 to about 20 weight percent cobalt oxide.

    NANOCERIA FOR THE TREATMENT OF OXIDATIVE STRESS
    8.
    发明授权
    NANOCERIA FOR THE TREATMENT OF OXIDATIVE STRESS 有权
    CERNANOPARTIKEL ZUR BEHANDLUNG VON氧化应变

    公开(公告)号：EP2861212B1

    公开(公告)日：2016-12-07

    申请号：EP13714425.9

    申请日：2013-03-15

    申请人： Cerion, LLC

    发明人： REED, Kenneth, Joseph ,  COSTANZO, Wendi, Ann ,  ERLICHMAN, Joseph, Samuel ,  BELL, Eric, Leslie

    IPC分类号： A61K9/10 ,  A61K9/51 ,  A61K33/00

    CPC分类号： A61K33/24 ,  A61K9/10 ,  A61K9/16 ,  A61K9/1694 ,  A61K9/5123 ,  A61K47/12 ,  A61K47/183 ,  A61L31/16 ,  B01J13/02 ,  B82Y5/00 ,  C01P2004/64

    摘要： A process for making nanoparticles of biocompatible materials is described, wherein an aqueous reaction mixture comprising cerous ion, citric acid and ethylenediaminetetraacetic acid in a predetermined ratio, an oxidant, and water is provided along with temperature conditions to directly form, without isolation, a stable dispersion of cerium oxide nanoparticles. These biocompatible cerium oxide nanoparticles may be used to prevent and/or treat oxidative stress related diseases, such as stroke, relapse/remitting multiple sclerosis, chronic-progressive multiple sclerosis, amyotrophic lateral sclerosis, and ischemic reperfusion injury.

    摘要翻译： 描述了制备生物相容性材料的纳米颗粒的方法，其中提供了包含预定比例的铈离子，柠檬酸和乙二胺四乙酸，氧化剂和水的含水反应混合物以及温度条件，以直接形成不分离的稳定的 二氧化铈纳米颗粒的分散体。 这些生物相容性氧化铈纳米颗粒可用于预防和/或治疗氧化应激相关疾病，例如中风，复发/缓解多发性硬化，慢性进行性多发性硬化，肌萎缩性侧索硬化和缺血再灌注损伤。