公开(公告)号：EP1732691A1

公开(公告)日：2006-12-20

申请号：EP04802393.1

申请日：2004-12-24

申请人： EPR Labautomation AG

发明人： BÜRGISSER, Ernst

IPC分类号： B01L3/02 ,  B01L11/00 ,  B01J19/00

CPC分类号： B01L3/0241 ,  B01J2219/00369 ,  B01J2219/00403 ,  B01J2219/0072 ,  B01L2300/0838 ,  B01L2400/0481

摘要： According to the invention, particularly small quantities (10) of liquids (3) that are to be dispensed, in particular in parallel dispensing steps in microtest plates, are stored in compressible tubular containers. To dispense said liquid, an end region (5) of the tubular container is separated, creating a new, open end region (5') with a defined level of liquid (F). A predetermined length (1) of said new end region (5') is compressed to dispense the liquid contained in said length. The container is then advanced and the compressed end region is separated again, producing a new, open end region with a defined level of liquid (F), which is then compressed for the subsequent dispensing step. The use of capillary tubes as containers permits the smallest quantities of liquid to be dispensed and said quantities can be reproduced extremely accurately. The device for carrying out the dispensing steps is simple and the liquid can be stored for long periods in the container between the dispensing steps without any problems.

公开(公告)号：EP1399745A2

公开(公告)日：2004-03-24

申请号：EP02732306.2

申请日：2002-06-10

申请人： EPR Labautomation AG

发明人： BÜRGISSER, Ernst

IPC分类号： G01N35/10 ,  B01L3/02 ,  F15C3/00

CPC分类号： B01L3/0265 ,  B01J2219/00783 ,  B01J2219/00871 ,  B01J2219/00891 ,  F16K99/0001 ,  F16K99/0011 ,  F16K2099/0076 ,  F16K2099/008 ,  F16K2099/0084 ,  G01N35/10 ,  G01N35/1074 ,  G01N2035/00247 ,  Y10T137/86879 ,  Y10T137/87249 ,  Y10T137/87917

摘要： A valve block (1) for a dosing device, with an arrangement of piston pipettes (2) or other dosing means, comprises, on the one side thereof, a pattern of openings (15) which may be placed on the arrangement of piston pipettes (2) and, on the opposite side thereof, a second opening (16) corresponding to each first opening (15). The valve block (1) further comprises a number of channel systems (20), each with a main connector (23). The valve block essentially comprises a number of plates (10, 11, 12, 13), arranged in a stack. All plates have through holes (14), arranged in the pattern of the first holes (15). At least a part of the plates (11, 12, 13) additionally comprises a channel system (20) with channels (21), connected to the main connector (23), whereby said channels (21) form a pattern which matches the pattern of the through holes (14) and is laterally displaced relative thereto. In order to optionally connect the first openings (15) to the corresponding second opening (16) or to a selected channel system (20), said plates (11, 12, 13) with the channel system are optionally laterally displaced.

公开(公告)号：EP1507592A1

公开(公告)日：2005-02-23

申请号：EP03718583.2

申请日：2003-05-12

申请人： EPR Labautomation AG

发明人： BÜRGISSER, Ernst

IPC分类号： B01L3/02 ,  G01N35/10 ,  G01F11/02

CPC分类号： G01F11/029 ,  B01L3/022 ,  B01L3/0234 ,  B01L3/0241 ,  B01L2400/02 ,  B01L2400/0622 ,  B01L2400/065 ,  G01F11/021 ,  G01N35/1016

摘要： The invention relates to a method for dosing a volume of liquid (VF) of less than 1 µl that is to be dispensed, by means of a dosing pump, in particular a pipette (2). According to said method, a tip (13) is completely filled with a liquid and contains the liquid (16) to be dispensed at least in the vicinity of its outlet (13a), a volume of gas (VL) is drawn into the tip (13) via the outlet (13a) and a volume corresponding to the sum of the volume of liquid (VF) to be dispensed and the volume of gas (VL) is then supplied to the tip (13) in such a way that the volume of liquid (VF) is dispensed via the outlet (13a) in a contactless manner. The device comprises a plurality of dosing pumps that can be simultaneously actuated, in particular pipettes (2), which can be actuated by an injection plunger (6), in addition to a motor (1), which drives the injection plungers (6) and also a valve (3), which is located between the dosing pump and its respective tip (13) in order to fill each system completely with liquid without any gas.

公开(公告)号：EP0363450B1

公开(公告)日：1992-11-19

申请号：EP89902221.4

申请日：1989-02-21

申请人： EPR Labautomation AG

发明人： Bürgisser, Ernst, Dr.

IPC分类号： B01L3/02

CPC分类号： G01N35/10 ,  G01N2035/1006

摘要： A device has a first driving motor (1) that drives with a spindle (1'), preferably in the vertical direction (z), a plurality of injection pistons (6) movable on a piston shaft (7), and a second driving motor (2) that movably drives a base plate (3) with a spindle (2'), preferably in the horizontal direction. A base plate with a plurality of pipette cylinders (5) arranged in the base plate (3) is pressed on a stationary valve plate (4) with a duct system (10) composed of channels (11, 12, 13) for supplying and removing a liquid. Each individual pipette is supported under spring bias by its outlet region on the valve plate with valve openings and may be moved if necessary under said spring bias on to the transfer surface. Each pipette has means for applying said spring bias.