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1.发明授权
公开(公告)号：EP2301572B1
公开(公告)日：2014-09-10
申请号：EP10075529.7
申请日：2006-11-01
IPC分类号： A61K39/12 , A61K39/145 , C12N7/00
CPC分类号： C12N7/00 , A61K39/12 , A61K39/145 , A61K2039/5252 , C12N2760/16134 , C12N2760/16151 , C12N2760/16234
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2.发明授权CELL-DERIVED VIRAL VACCINES WITH LOW LEVELS OF RESIDUAL CELL DNA BY BETA-PROPIOLACTONE TREATMENT 有权残余细胞DNA的低量的CELL ORIGINATING病毒疫苗
公开(公告)号：EP1951296B2
公开(公告)日：2014-07-23
申请号：EP06831855.9
申请日：2006-11-01
IPC分类号： A61K39/13 , A61K39/145
CPC分类号： C12N7/00 , A61K39/12 , A61K39/145 , A61K2039/5252 , C12N2760/16134 , C12N2760/16151 , C12N2760/16234
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3.发明公开
公开(公告)号：EP2471551A3
公开(公告)日：2012-11-14
申请号：EP12157945.2
申请日：2005-09-09
IPC分类号： A61K39/145 , C12Q1/70
CPC分类号： C12N7/00 , A61K39/12 , A61K39/145 , C12N2760/16034 , C12N2760/16051 , C12N2760/16134 , C12N2760/16234 , C12Q1/70 , C12Q1/701 , G01N33/56983 , G01N2333/11 , Y02A50/467
摘要： Influenza viruses for use in preparing human vaccines have traditionally been grown on embryonated hen eggs, although more modern techniques grow the virus in mammalian cell culture e.g. on Vero, MDCK or PER.C6 cell lines. The inventor has realised that the conditions used for influenza virus culture can increase the risk that pathogens other than influenza virus may grow in the cell lines and have identified specific contamination risks. Suitable tests can thus be performed during manufacture in order to ensure safety and avoid iatrogenic infections.
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4.发明公开
公开(公告)号：EP2471551A2
公开(公告)日：2012-07-04
申请号：EP12157945.2
申请日：2005-09-09
IPC分类号： A61K39/145 , C12Q1/70
CPC分类号： C12N7/00 , A61K39/12 , A61K39/145 , C12N2760/16034 , C12N2760/16051 , C12N2760/16134 , C12N2760/16234 , C12Q1/70 , C12Q1/701 , G01N33/56983 , G01N2333/11 , Y02A50/467
摘要： Influenza viruses for use in preparing human vaccines have traditionally been grown on embryonated hen eggs, although more modern techniques grow the virus in mammalian cell culture e.g. on Vero, MDCK or PER.C6 cell lines. The inventor has realised that the conditions used for influenza virus culture can increase the risk that pathogens other than influenza virus may grow in the cell lines and have identified specific contamination risks. Suitable tests can thus be performed during manufacture in order to ensure safety and avoid iatrogenic infections.
摘要翻译： 用于制备人疫苗的流感病毒传统上是在胚胎发育的鸡蛋上生长的，尽管更现代的技术在哺乳动物细胞培养物中培养病毒，例如， 在Vero，MDCK或PER.C6细胞系上。 发明人已经意识到用于流感病毒培养的条件可以增加流感病毒以外的病原体可能在细胞系中生长并鉴定出特定污染风险的风险。 因此可以在制造过程中进行合适的测试以确保安全并避免医源性感染。
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公开(公告)号：EP1430109B1
公开(公告)日：2012-01-04
申请号：EP02782795.5
申请日：2002-09-25
发明人： DIETRICH, Guido , HUNDT, Erika , WEBER, Heinz
IPC分类号： C12N1/20
CPC分类号： C12Q1/045 , C12N1/20 , G01N2333/35
摘要： The present invention relates to a culture medium for disperse mycobacteria comprising at least one detergent and an antifoam agent, whereby said antifoam agent is a member of the silicone family. In addition, the invention provides for methods for the activation of dipressed mycobacteria, for obtaining a standardized mycobyterial culture or for the production of (a), purified protein derivates(s) (PDD) which comprise the cultivation of mycobacteria in the active medium disclosed herein. Furthermore, the use of standardized mycobacterial cultures obtained by the method of the invention for the preparation of pharmaceutical or diagnostic compositions is described.
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公开(公告)号：EP2308505A3
公开(公告)日：2011-11-30
申请号：EP10176773.9
申请日：2006-09-01
发明人： Borkowski, Astrid
IPC分类号： A61K39/09 , A61K39/095 , A61K39/13 , A61K39/29 , A61K39/295 , A61K39/116
CPC分类号： A61K39/102 , A61K39/0018 , A61K39/05 , A61K39/08 , A61K39/092 , A61K39/095 , A61K39/099 , A61K2039/545 , A61K2039/55 , A61K2039/70 , C12N2730/10134 , C12N2770/32634 , Y02A50/466
摘要： A scrogroup C meningococcal conjugate antigen is co-administcrcd with a pneumococcal saccharide conjugate which is in a liquid form. A kit may have: (a) a first immunogenic component that comprises an aqueous formulation of a conjugated capsular saccharide from Streptococcus pneumoniae ; and (b) a second immunogenic component that comprises a conjugated capsular saccharide from Neisseria meningitidis serogroup C.
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7.发明授权Verfahren zur Herstellung eines aktiven Bestandteils eines Arznei- oder Diagnosemittels im MDCK-Zell-Suspensionskultur 有权一种用于在MDCK细胞悬浮培养物制备的药物或诊断剂的活性成分的过程
公开(公告)号：EP2011862B1
公开(公告)日：2011-06-08
申请号：EP08018057.3
申请日：2002-09-11
CPC分类号： C12N7/00 , A61K39/00 , A61K2039/5252 , C12N2710/10051 , C12N2710/16651 , C12N2710/16751 , C12N2710/24151 , C12N2720/12051 , C12N2720/12351 , C12N2760/16251 , C12N2760/18051 , C12N2760/18551 , C12N2760/20151 , C12N2770/24151 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/464 , Y02A50/466
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8.发明公开Animal cells and processes for the replication of influenza viruses 失效Tierzellen und Verfahrensfürdie Replikation von Influenza Viren
公开(公告)号：EP2275535A1
公开(公告)日：2011-01-19
申请号：EP10075278.1
申请日：1997-04-01
发明人： Gröner, Albrecht , Vorlop, Jürgen
IPC分类号： C12N7/00 , A61K39/145
CPC分类号： C12N7/00 , A61K39/12 , A61K39/145 , A61K2039/5252 , C12N2760/16134 , C12N2760/16151
摘要： Animal cells are described which can be infected by influenza viruses and which are adapted to growth in suspension in serum-free medium. Processes for the replication of influenza viruses in cell culture using these cells are furthermore described, as well as vaccines which contain the influenza viruses obtainable by the process or constituents thereof.
摘要翻译： 描述了可被流感病毒感染并且适于在无血清培养基中悬浮生长的动物细胞。 此外还描述了使用这些细胞在细胞培养物中复制流感病毒的方法，以及含有通过该方法或其组分可获得的流感病毒的疫苗。
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9.发明公开Verfahren zur Herstellung eines aktiven Bestandteils eines Arznei- oder Diagnosemittels im MDCK-Zell-Suspensionskultur 有权一种用于在MDCK细胞悬浮培养物制备的药物或诊断剂的活性成分的过程
公开(公告)号：EP2011862A1
公开(公告)日：2009-01-07
申请号：EP08018057.3
申请日：2002-09-11
CPC分类号： C12N7/00 , A61K39/00 , A61K2039/5252 , C12N2710/10051 , C12N2710/16651 , C12N2710/16751 , C12N2710/24151 , C12N2720/12051 , C12N2720/12351 , C12N2760/16251 , C12N2760/18051 , C12N2760/18551 , C12N2760/20151 , C12N2770/24151 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/464 , Y02A50/466
摘要： Verfahren zur Herstellung eines aktiven Bestandteils eines Impfstoffs, Schritte umfassend, bei denen man (a)MDCK-Zellen, die in Serum-freien Medium kultiviert wurden, mit einem Primärvirus infiziert, um einen Saatvorrat eines Virus zu erzeugen; (b) eine Kultur von MDCK-Zellen mit dem Saatvorrat des Virus infiziert; und (c) die Kultur von MDCK-Zellen in einem kommerziellen Maßstab unter Bedingungen kultiviert, die eine Vermehrung der Viren ermöglichen.
摘要翻译： 通过治疗或诊断剂的活性成分（I）的制备：（ⅰ）感染Mandine-Darby犬肾（MDCK）细胞与病毒; 和（ii）培养大规模（即培养物体积至少为30升）上在悬浮培养中的细胞，所以没有病毒复制发生。 因此独立claimsoft是通过配制由与佐剂，助剂，缓冲剂，稀释剂或载体中的新的方法制备的（I）包括用于制备治疗或诊断组合物。 活动：杀病毒剂。 无生物数据给出。 作用机制：疫苗。
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10.发明公开Decreasing potential iatrogenic risks associated with vaccine antigens 有权Verringerung potentieller iatrogener，mit ImpfstoffenzusammenhängenderRisiken
公开(公告)号：EP2578229A1
公开(公告)日：2013-04-10
申请号：EP12193096.0
申请日：2005-09-09
IPC分类号： A61K39/145 , C12Q1/70
CPC分类号： C12N7/00 , A61K39/12 , A61K39/145 , C12N2760/16034 , C12N2760/16051 , C12N2760/16134 , C12N2760/16234 , C12Q1/70 , C12Q1/701 , G01N33/56983 , G01N2333/11 , Y02A50/467
摘要： The inventor has realised that certain pathogens can grow in mammalian cells, in particular Vero cells, and that these pathogens could pose a contamination risk when producing vaccine antigens in these cells. The invention thus provides methods to test for these pathogens.
摘要翻译： 发明人已经意识到某些病原体可以在哺乳动物细胞，特别是Vero细胞中生长，并且当在这些细胞中产生疫苗抗原时，这些病原体可能会产生污染风险。 因此，本发明提供了测试这些病原体的方法。
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