公开(公告)号：EP2794471B1

公开(公告)日：2018-02-07

申请号：EP12809843.1

申请日：2012-12-17

申请人： Sirakoss Limited

发明人： GIBSON, Iain, Ronald ,  SKAKLE, Janet, Mabel, Scott ,  CONWAY, Jordan, Christopher

IPC分类号： C01B25/32 ,  A61L27/12 ,  A61L27/56

CPC分类号： A61L27/12 ,  A61L27/56 ,  A61L2400/12 ,  C01B25/32 ,  C01B25/322 ,  C01B25/327

摘要： The invention relates to porous granular calcium phosphate osteoinductive materials, particularly materials useful in body tissue repair, principally bone repair and bone replacement, and also to the use of such materials and to a method of making such materials. Exemplary materials comprise discrete porous granules each containing crystals of at least one calcium phosphate, wherein (i) at least 90% of said crystals of the granules have a crystal size in the range 10-100 nm, (ii) at least 90% of the pores in the granules have a pore size in the range 10-500 nm, (iii) the average pore size of the pores having pore size in the range 10-500 nm in the granules is in the range 30-90 nm, (iv) the total volume porosity of the granules is at least 50%, and (v) the surface area of the granules is in the range 10-70 m2/g.

公开(公告)号：EP2381970B1

公开(公告)日：2017-04-12

申请号：EP09796031.4

申请日：2009-12-23

申请人： Sirakoss Limited

发明人： GIBSON, lain Ronald ,  SKAKLE, Janet Mabel Scott

IPC分类号： A61L27/12 ,  C01B25/32

CPC分类号： A61L27/12 ,  C01B25/32 ,  C01B25/322

公开(公告)号：EP2794471A1

公开(公告)日：2014-10-29

申请号：EP12809843.1

申请日：2012-12-17

申请人： The University Court of The University of Aberdeen ,  Sirakoss Limited

发明人： GIBSON, Iain, Ronald ,  SKAKLE, Janet, Mabel, Scott ,  CONWAY, Jordan, Christopher

IPC分类号： C01B25/32

CPC分类号： A61L27/12 ,  A61L27/56 ,  A61L2400/12 ,  C01B25/32 ,  C01B25/322 ,  C01B25/327

摘要： The invention relates to porous granular calcium phosphate osteoinductive materials, particularly materials useful in body tissue repair, principally bone repair and bone replacement, and also to the use of such materials and to a method of making such materials. Exemplary materials comprise discrete porous granules each containing crystals of at least one calcium phosphate, wherein (i) at least 90% of said crystals of the granules have a crystal size in the range 10-100 nm, (ii) at least 90% of the pores in the granules have a pore size in the range 10-500 nm, (iii) the average pore size of the pores having pore size in the range 10-500 nm in the granules is in the range 30-90 nm, (iv) the total volume porosity of the granules is at least 50%, and (v) the surface area of the granules is in the range 10-70 m2/g.