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    INTRINSICALLY MAGNETIC HYDROXYAPATITE
    5.
    发明公开
    INTRINSICALLY MAGNETIC HYDROXYAPATITE 有权
    INTRINSICH MAGNETISCHE HYDROXYLAPATIT

    公开(公告)号：EP2598437A1

    公开(公告)日：2013-06-05

    申请号：EP11752344.9

    申请日：2011-07-28

    申请人： University of Santiago de Compostela

    发明人： TAMPIERI, Anna ,  LANDI, Elena ,  SANDRI, Monica ,  PRESSATO, Daniele ,  RIVAS REY, José ,  BANOBRE LOPEZ, Manuel ,  MARCACCI, Maurilio

    IPC分类号： C01B25/32 ,  C01B25/45 ,  A61L27/12

    CPC分类号： A61K47/02 ,  A61K49/0002 ,  A61K49/08 ,  A61L27/12 ,  A61L27/54 ,  A61L2300/414 ,  A61L2300/64 ,  A61L2400/12 ,  A61L2430/02 ,  A61L2430/06 ,  C01B25/32 ,  C01B25/322 ,  C01B25/45 ,  C01P2004/62 ,  C01P2006/62 ,  C01P2006/64

    摘要： The present invention relates to hydroxyapatite doped with Fe
    2 + ions and Fe
    3 + ions which partially substitute the calcium ions in the crystal lattice. The hydroxyapatite is characterized by an intrinsic magnetism of 0.05 to 8 emu/g, measured by applying a magnetic field of 34 Oe, due to the presence of magnetic nano-domains in the crystal lattice of HA, given the limited amount of magnetic secondary phases present, less than about 3% by volume. The intrinsically magnetic hydroxyapatite can be loaded with biological substances selected in the group consisting of proteins, genes, stem cells, growth factors, vascularization factors, active substances and drugs, under the control of an external magnetic field, as a carrier and release agent for biological substances or drugs, as a contrast agent in diagnostics or for bone or osteocartilage regeneration.

    摘要翻译： 本发明涉及掺杂有Fe2 +离子的羟基磷灰石和部分代替晶格中的钙离子的Fe 3+离子。 由于在HA的晶格中存在磁性纳米结构域，所以羟基磷灰石的特征在于通过施加34Oe的磁场测量的0.05至8emu / g的固有磁性，因为有限量的磁性次级 存在，小于约3体积％。 本征磁性羟基磷灰石可以在外部磁场的控制下装载由蛋白质，基因，干细胞，生长因子，血管形成因子，活性物质和药物组成的组中选择的生物物质作为载体和脱模剂 生物物质或药物，作为诊断或骨或骨软骨再生的造影剂。

    CALCIUM SECONDARY PHOSPHATE ANHYDRIDE PARTICLE AND METHOD FOR PRODUCING THE SAME
    6.
    发明公开
    CALCIUM SECONDARY PHOSPHATE ANHYDRIDE PARTICLE AND METHOD FOR PRODUCING THE SAME 有权
    甲基六氢呋喃 - 巴比妥酸酯在HERSTELLUNGSVERFAHRENDAFÜR

    公开(公告)号：EP2208705A1

    公开(公告)日：2010-07-21

    申请号：EP08832423.1

    申请日：2008-09-18

    申请人： KYOWA CHEMICAL INDUSTRY CO., LTD.

    发明人： KITAKADO, Kazuo

    IPC分类号： C01B25/32 ,  A23L1/03 ,  A61K9/20 ,  A61K9/48 ,  A61K47/04

    CPC分类号： C01B25/322 ,  A23L29/015 ,  A23P10/20 ,  A61K9/2009 ,  A61K9/2095 ,  A61K47/02 ,  C01P2004/62 ,  Y10T428/2982

    摘要： The present invention provides anhydrous dicalcium phosphate particles which satisfies the conflicting requirements of the improvement of handling properties such as high flowability and a small bulk and the improvement of tableting properties at the same time during preparation and a method of producing the same.
    The method of producing anhydrous dicalcium phosphate by heating water suspensions of a phosphoric acid compound and a calcium compound at 50 to 100°C, comprises the step of:
    heating the phosphoric acid compound and the calcium compound at 75°C or higher in advance to carry out a neutralization reaction in the presence of an alkali to obtain agglomerated anhydrous dicalcium phosphate particles.

    摘要翻译： 本发明提供了无水磷酸二钙颗粒及其制备方法，其满足诸如高流动性和小体积等操作性能的改善和制备时同时提高压片性能的矛盾要求。 通过在50〜100℃下加热磷酸化合物和钙化合物的水悬浮液来制造无水磷酸氢钙的方法包括以下步骤：将磷酸化合物和钙化合物加热至75℃以上， 在碱的存在下进行中和反应，得到凝聚的无水磷酸二钙颗粒。

    METHOD FOR PRODUCING NANO-SIZED CRYSTALLINE HYDROXYAPATITE
    7.
    发明公开
    METHOD FOR PRODUCING NANO-SIZED CRYSTALLINE HYDROXYAPATITE 有权
    用于生产NANODIMENTIONIERTEM晶羟基磷灰石

    公开(公告)号：EP1296888A1

    公开(公告)日：2003-04-02

    申请号：EP00954822.3

    申请日：2000-07-03

    申请人： Zakrytoe Aktsionernoe Obschestvo OSTIM

    发明人： RUDIN, Vsevolod Nikolaevich ,  KOMAROV, Vladimir Fedorovich ,  MELIKHOV, Igor Vitallevich ,  MINAEV, Vladimir Vasillevich ,  ORLOV, Andrei Yurevich ,  BOZHEVOINOV, Viktor Evgenievich

    IPC分类号： C01B25/32

    CPC分类号： C01B25/322

    摘要： The present invention especially relates to the mechanism and to the technological process for synthesizing nanosized crystalline hydroxyapatite. In particular, for producing nano-sized crystalline hydroxyapatite whose particles have nano dimensions in length 'l', width, 'd' and thickness 'h', wherein 'h' is practically corresponding to the size of one transmission of crystallographic cell a method is disclosed involving the steps of mixing and homogenizing a suspension comprising calcium hydroxide with an amount of phosphoric acid within a first reactor thereby adjusting a defined alkaline pH-value of the resulting mixture, feeding the mixture into a second reactor for causing phase transformations of the mixture and feeding the mixture into a third reactor for providing a suspension by adding a suspension of calcium hydroxide to the mixture to then feed the suspension into the first reactor, whereby each of these steps is cyclically carried out in continuos periodical conditions within at least three stages thereby producing nano-sized crystalline particles of pure hydroxyapatite as a solid phase.