公开(公告)号：EP4412651A1

公开(公告)日：2024-08-14

申请号：EP22879481.4

申请日：2022-10-06

申请人： The Wistar Institute of Anatomy and Biology

发明人： WEINER, David ,  PERALES-PUCHALT, Alfredo ,  BORDOLOI, Devivasha ,  BHOJNAGARWALA, Pratik

IPC分类号： A61K39/395 ,  A61P35/00 ,  C07K16/30

CPC分类号： A61P35/00 ,  C07K2317/3120130101 ,  C07K16/2869 ,  C07K16/2809 ,  A61K2039/50520130101 ,  C07K2317/7320130101

公开(公告)号：EP3294705B1

公开(公告)日：2021-07-21

申请号：EP16793664.0

申请日：2016-05-14

发明人： MESSICK, Troy E. ,  SMITH, Garry R. ,  REITZ, Allen B. ,  LIEBERMAN, Paul M. ,  MCDONNELL, Mark E. ,  ZHANG, Yan ,  CARLSEN, Marianne ,  CHEN, Shuai

IPC分类号： C07D403/12 ,  C07D405/14 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12 ,  C07D471/08 ,  C07D487/08 ,  C07D209/08 ,  A61K31/404 ,  A61P35/00

公开(公告)号：EP3200815B1

公开(公告)日：2021-03-03

申请号：EP15847792.7

申请日：2015-09-30

发明人： PERALES-PUCHALT, Alfredo ,  CONEJO-GARCIA, Jose R.

IPC分类号： C07K14/59 ,  C07K14/705 ,  A61K38/24 ,  A61K38/00 ,  A61K38/17

公开(公告)号：EP3149210B1

公开(公告)日：2020-08-05

申请号：EP15803142.7

申请日：2015-06-02

申请人： Valley Health System ,  The Wistar Institute

发明人： GUMIREDDY, Kiranmai ,  HUANG, Qihong ,  SHOWE, Louise, C. ,  GANEPOLA, Ganepola, A.P.

IPC分类号： C12Q1/6886

公开(公告)号：EP3548072A1

公开(公告)日：2019-10-09

申请号：EP17876616.8

申请日：2017-12-01

申请人： The Trustees of the University of Pennsylvania ,  The Wistar Institute Of Anatomy And Biology

发明人： WEINER, David, B. ,  ELLIOTT, Sarah ,  PATEL, Ami

IPC分类号： A61K39/00 ,  A61K39/12 ,  C07K14/005 ,  C12N7/00 ,  C12N15/67

公开(公告)号：EP3452090A1

公开(公告)日：2019-03-13

申请号：EP17793526.9

申请日：2017-05-05

申请人： The Trustees of The University of Pennsylvania ,  The Wistar Institute Of Anatomy And Biology ,  Inovio Pharmaceuticals, Inc.

发明人： WEINER, David ,  PATEL, Ami ,  YAN, Jian

IPC分类号： A61K39/40 ,  C07K16/00 ,  C07K16/12

公开(公告)号：EP3200815A1

公开(公告)日：2017-08-09

申请号：EP15847792.7

申请日：2015-09-30

申请人： The Wistar Institute Of Anatomy And Biology

发明人： PERALES-PUCHALT, Alfredo ,  CONEJO-GARCIA, Jose R.

IPC分类号： A61K38/24

CPC分类号： C07K14/59 ,  A61K38/00 ,  C07K14/705 ,  C07K14/7051 ,  C07K14/70517 ,  C07K14/70521 ,  C07K14/70564 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/03

摘要： A nucleic acid sequence is provided that encodes a chimeric protein comprising a ligand that comprises a naturally occurring or modified follicle stimulating hormone sequence, e.g., an FSHp sequence, or fragment thereof, which ligand binds to human follicle stimulating hormone (FSH) receptor, linked to either (a) a nucleic acid sequence that encodes an extracellular hinge domain, a transmembrane domain, a co-stimulatory signaling region, and a signaling endodomain; or (b) a nucleic acid sequence that encodes a ligand that binds to NKG2D. The vector containing the nucleic acid sequence, the chimeric proteins so encoded, and modified T cells expressing the chimeric protein, as well as method of using these compositions for the treatment of FSHR-expressing cancers or tumor cells are also provided.

摘要翻译： 提供编码嵌合蛋白的核酸序列，所述嵌合蛋白包含配体，所述配体包含天然存在的或修饰的促卵泡激素序列，例如FSHp序列或其片段，所述配体结合人卵泡刺激素（FSH）受体， （a）编码细胞外铰链结构域，跨膜结构域，共刺激信号传导区域和信号传导内源结构域的核酸序列; 或（b）编码结合NKG2D的配体的核酸序列。 还提供了包含核酸序列的载体，如此编码的嵌合蛋白以及表达嵌合蛋白的修饰的T细胞，以及使用这些组合物治疗表达FSHR的癌症或肿瘤细胞的方法。

公开(公告)号：EP2461835A1

公开(公告)日：2012-06-13

申请号：EP10807205.9

申请日：2010-08-06

申请人： The Wistar Institute

发明人： ROESCH, Alexander, O. ,  HERLYN, Meenhard

IPC分类号： A61K51/00 ,  A61M36/14

CPC分类号： A61K45/06 ,  A61K31/7105 ,  A61K38/1709 ,  A61K2300/00

摘要： The present invention features compositions and methods for treating cancers such as melanoma, which have a subpopulation of self -renewing JARIDIB-positive cells essential to maintenance and metastatic progression of the cancer.

公开(公告)号：EP2205759A1

公开(公告)日：2010-07-14

申请号：EP08840994.1

申请日：2008-10-21

申请人： The Wistar Institute

发明人： SKORDALAKES, Emmanuel

IPC分类号： C12Q1/48

CPC分类号： C12Q1/48 ,  G01N2333/91245

摘要： The present invention relates to a method for identifying compounds that modulate the activity of telomerase. Compounds of the invention are identified by designing or screening for a compound which binds to at least one amino acid residue of the TRBD, 'thumb,' 'finger,' and/or 'palm' domain of telomerase and testing the compound for its ability to modulate the activity of telomerase.

公开(公告)号：EP1770168A3

公开(公告)日：2009-05-06

申请号：EP06077327.2

申请日：1994-01-26

申请人： The Trustees of the University of Pennsylvania (a corporation of Pennsylvania) ,  THE WISTAR INSTITUTE ,  Wyeth

发明人： Weiner, David B. ,  Williams, WIlliam V. ,  Wang, Bin ,  Coney, Leslie R. ,  Merva, Michael J. ,  Zurawski, Vincent R., Jr.

IPC分类号： C12N15/87 ,  C12N15/12 ,  C12N15/33 ,  C12N15/48 ,  A61K31/70 ,  A61K48/00

CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K39/12 ,  A61K39/21 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/55566 ,  A61K2039/57 ,  C12N15/87 ,  C12N2740/16034 ,  C12N2740/16122 ,  C12N2740/16134 ,  C12N2740/16222 ,  C12N2740/16234 ,  C12N2740/16322 ,  Y02A90/26

摘要： Methods of introducing genetic material into cells of an individual and compositions and kits for practicing the same are disclosed. The methods comprise the steps of contacting cells of an individual with a polynucleotide function enhancer and administering to the cells, a nucleic acid molecule that is free of retroviral particles. The nucleic acid molecule comprises a nucleotide sequence that encodes a protein that comprises at least one epitope that is identical or substantially similar to an epitope of a pathogen antigen or an antigen associated with a hyperproliferative or autoimmune disease, a protein otherwise missing from the individual due to a missing, non-functional or partially functioning gene, or a protein that produces a therapeutic effect on an individual. Methods of prophylactically and therapeutically immunizing an individual against HIV are disclosed. Pharmaceutical compositions and kits for practicing methods of the present invention are disclosed.