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    MANUFACTURING METHOD FOR SOFTGEL CAPSULE CONTAINING SOLID AND LIQUID FORMULATIONS AS CORE INGREDIENT
    9.
    发明公开
    MANUFACTURING METHOD FOR SOFTGEL CAPSULE CONTAINING SOLID AND LIQUID FORMULATIONS AS CORE INGREDIENT 审中-公开
    HERSTELLUNGSVERFAHRENFÜRSOFTGELKAPSEL MIT FESTEN UNDFLÜSSIGENFORMULIERUNGEN ALS KERNBESTANDTEIL

    公开(公告)号：EP3141247A1

    公开(公告)日：2017-03-15

    申请号：EP15188232.1

    申请日：2015-10-02

    申请人： Suheung Co., Ltd

    发明人： YANG, Joo-Hwan ,  PARK, Geum Duk

    IPC分类号： A61K9/48

    CPC分类号： A61K9/4808 ,  A61K9/4833

    摘要： The present invention relates to a manufacturing method for softgel capsule containing solid and liquid formulations as core ingredient, wherein at least one pharmaceutical drug can be included in both solid formulation and liquid formulation. More particularly, this invention relates to a softgel capsule wherein liquid formulation, for example, solution and/or suspension as well as solid formulation, for example, tablet, pellet and/or sustained release dosage are present as core ingredient and its manufacturing method.

    摘要翻译： 本发明涉及含有固体和液体制剂作为核心成分的软胶囊的制备方法，其中至少一种药物可以包括在固体制剂和液体制剂中。 更具体地，本发明涉及一种软胶囊，其中液体制剂例如溶液和/或悬浮液以及固体制剂，例如片剂，丸剂和/或持续释放剂量作为核心成分及其制备方法存在。

    SURGICAL DEVICE
    10.
    发明公开
    SURGICAL DEVICE 审中-公开
    手术设备

    公开(公告)号：EP3097869A1

    公开(公告)日：2016-11-30

    申请号：EP16178984.7

    申请日：2008-09-22

    申请人： Covidien LP

    发明人： MALINOUSKAS, Donald ,  WHITMAN, Michael P. ,  DATCUK, Peter ,  NICHOLAS, David A.

    IPC分类号： A61B17/072 ,  A61B17/29 ,  A61B17/32

    摘要： A surgical device, comprising:
    a first jaw;
    a second jaw in opposed correspondence to the first jaw;
    a shaft pivotably coupled to at least one of the first or second jaws, the shaft defining a longitudinal axis therethrough that is perpendicular to a pivot axis;
    a first driver coupled to a first rotatable drive shaft, the first driver configured to move the first jaw relative to the second jaw;
    a second driver coupled to a second rotatable drive shaft, the second driver configured to drive a cutting and stapling element included in the second jaw;
    a first gear train having a first gear element arrangement, the first gear train configured to meshingly engage the first rotatable drive shaft;
    a second gear train having a second gear element arrangement, the second gear train configured to meshingly engage the second rotatable drive shaft;
    wherein the first and second gear trains enable rotation of the first and second jaws relative to the longitudinal axis defined by the shaft;
    a first bevel gear element and a second bevel gear element each rotatably mounted about a pin, at least one of the first or second gear elements having a central axis coaxial with the pivot axis around which the at least one of the first or second jaws pivots relative to the shaft, wherein the first and second bevel gear elements are actuatable by the first and second rotatable drive shafts, respectively, to position the first jaw relative to the second jaw; and
    a wedge member mechanically cooperating with a wedge driver, the wedge driver actuated by one of the first gear train or the second gear train, wherein a displacement of the first jaw relative to the second jaw and a displacement of the wedge member is a function of a rotation of the first and second rotatable drive shafts.

    摘要翻译： 一种手术装置，包括：第一钳口; 与第一钳口相对应的第二钳口; 可枢转地联接到所述第一或第二夹爪中的至少一个上的轴，所述轴限定穿过其中的纵向轴线，所述纵向轴线垂直于枢转轴线; 联接到第一可旋转驱动轴的第一驱动器，所述第一驱动器构造成使所述第一钳口相对于所述第二钳口移动; 联接到第二可旋转驱动轴的第二驱动器，所述第二驱动器构造成驱动包括在所述第二夹爪中的切割和吻合元件; 第一齿轮系，其具有第一齿轮元件装置，所述第一齿轮系构造成与所述第一可旋转驱动轴啮合; 具有第二齿轮元件装置的第二齿轮系，所述第二齿轮系构造成与所述第二可旋转驱动轴啮合; 其中所述第一和第二齿轮系能够使所述第一和第二钳口相对于由所述轴限定的所述纵向轴线旋转; 第一伞齿轮元件和第二伞齿轮元件，所述第一伞齿轮元件和第二伞齿轮元件各自围绕销可旋转地安装，所述第一或第二齿轮元件中的至少一个具有与所述枢转轴线同轴的中心轴，所述第一或第二爪中的至少一个枢转 其中所述第一和第二伞齿轮元件可分别由所述第一和第二可旋转驱动轴致动以将所述第一夹爪相对于所述第二夹爪定位; 以及与楔形件驱动器机械配合的楔形件，所述楔形件由所述第一齿轮系或所述第二齿轮系中的一个驱动，其中所述第一钳口相对于所述第二钳口的位移和所述楔形件的位移是函数 第一和第二可旋转驱动轴的旋转。