公开(公告)号：EP3799884A1

公开(公告)日：2021-04-07

申请号：EP19200878.7

申请日：2019-10-01

申请人： GlaxoSmithKline Biologicals S.A.

发明人： The designation of the inventor has not yet been filed

IPC分类号： A61K39/02 ,  C07K14/235

摘要： The invention relates to bacterial strains, particularly for use in the field of vaccines, in particular to the field of the prevention or treatment of infections caused by bacterium of the Bordetella genus.

公开(公告)号：EP3482770A1

公开(公告)日：2019-05-15

申请号：EP18214396.6

申请日：2013-10-03

申请人： GlaxoSmithKline Biologicals S.A.

发明人： GRANDI, Guido ,  MARGARIT Y ROS, Immaculada ,  MAIONE, Domenico

IPC分类号： A61K39/09

摘要： The invention provides an immunogenic composition comprising: a) a conjugate that is a capsular saccharide from GBS serotype Ia conjugated to a carrier protein; b) a conjugate that is a capsular saccharide from GBS serotype Ib conjugated to a carrier protein; c) a conjugate that is a capsular saccharide from GBS serotype III conjugated to a carrier protein; d) a conjugate that is a capsular saccharide from GBS serotype II conjugated to a carrier protein; and e) a conjugate that is a capsular saccharide from GBS serotype V conjugated to a carrier protein.

公开(公告)号：EP3316904A1

公开(公告)日：2018-05-09

申请号：EP16734627.9

申请日：2016-06-30

申请人： GlaxoSmithKline Biologicals S.A.

发明人： CAMPISI, Edmondo ,  MARGARIT Y ROS, Immaculada ,  ROSINI, Roberto

IPC分类号： A61K39/09

CPC分类号： A61K39/092 ,  A61K2039/55505 ,  A61K2039/6037 ,  A61K2039/6068 ,  A61K2039/70

摘要： The invention provides chimeric capsular polysaccharides including conjugates comprising same. The invention also provides pharmaceutical compositions comprising chimeric capsular polysaccharides and conjugates thereof. Further aspects comprise methods for immunising a patient against infection comprising the step of administering to the patient a conjugate of the invention.

公开(公告)号：EP3110442A1

公开(公告)日：2017-01-04

申请号：EP15707351.1

申请日：2015-02-27

申请人： GlaxoSmithKline Biologicals SA

发明人： BOTTOMLEY, Matthew ,  MALITO, Enrico ,  MARTINELLI, Manuele ,  SCARSELLI, Maria

IPC分类号： A61K39/095 ,  C07K14/22 ,  C07K14/095

CPC分类号： C07K14/22 ,  A61K39/095 ,  A61K2039/523 ,  A61K2039/55511 ,  A61K2039/70

摘要： Modified meningococcal fHbp polypeptides with increased stability.

摘要翻译： 修饰脑膜炎球菌fHbp多肽具有增加的稳定性。

公开(公告)号：EP2184071B1

公开(公告)日：2016-08-31

申请号：EP09075005.0

申请日：2002-06-20

申请人： GlaxoSmithKline Biologicals SA

发明人： Costantino, Paolo

IPC分类号： A61K39/095 ,  A61K39/385 ,  A61P31/04 ,  C12P19/04

CPC分类号： A61K39/095 ,  A23J1/04 ,  A23J1/205 ,  A61K38/00 ,  A61K38/4893 ,  A61K39/092 ,  A61K39/102 ,  A61K39/39 ,  A61K2039/545 ,  A61K2039/55505 ,  A61K2039/6037 ,  C07H15/04 ,  C07K14/22 ,  C07K14/285 ,  C09F1/00 ,  C09G1/00 ,  Y02A50/466 ,  Y10S424/831

摘要： Precipitated bacterial capsular polysaccharides can be efficiently re-solubilised using alcohols as solvents. The invention provides a process for purifying a bacterial capsular polysaccharide, comprising the steps of (a) precipitation of said polysaccharide, followed by (b) solubilisation of the precipitated polysaccharide using ethanol. CTAB can be used for step (a). The material obtained, preferably following hydrolysis and sizing, can be conjugated to a carrier protein and formulated as a vaccine. Also, in vaccines comprising saccharides from both serogroups A and C, the invention provides that the ratio (w/w) of MenA saccharide : MenC saccharide is >1.

公开(公告)号：EP2897637A1

公开(公告)日：2015-07-29

申请号：EP13802107.6

申请日：2013-09-19

申请人： Novartis AG

发明人： GALEOTTI, Cesira ,  LEUZZI, Rosanna ,  PIZZA, Mariagrazia ,  SCARSELLI, Maria ,  UNNIKRISHNAN, Meera ,  MARTINELLI, Manuele

IPC分类号： A61K39/08 ,  A61K39/40 ,  C07K14/33 ,  C07K16/12 ,  C12N15/31 ,  A61P31/04

CPC分类号： C07K14/33 ,  A61K39/08 ,  A61K2039/55505 ,  A61K2039/55566 ,  A61K2039/70 ,  C07K16/1282

摘要： The invention provides methods, proteins, nucleic acids and antibodies for preventing or treating a C. difficile infection in a mammal.

公开(公告)号：EP3699263A1

公开(公告)日：2020-08-26

申请号：EP19158847.4

申请日：2019-02-22

申请人： GlaxoSmithKline Biologicals S.A.

发明人： The designation of the inventor has not yet been filed

IPC分类号： C12N1/20 ,  A61K39/00

摘要： The present invention relates to processes for Bordetella fermentation and virulence factor production, especially PT production, for large scale manufacturing. More particularly, processes including a medium conditioning step carried out prior to inoculation.

公开(公告)号：EP3587581A1

公开(公告)日：2020-01-01

申请号：EP18179977.6

申请日：2018-06-26

申请人： GlaxoSmithKline Biologicals S.A.

发明人： The designation of the inventor has not yet been filed

IPC分类号： C12N15/86

摘要： The invention relates to liquid formulations of simian adenoviruses and methods for obtaining the formulations. The formulations comprise an amorphous sugar, a surfactant, a bivalent metal salt and an alpha tocopherol in a buffered solution.

公开(公告)号：EP3498302A1

公开(公告)日：2019-06-19

申请号：EP18194584.1

申请日：2006-02-01

申请人： Novartis Vaccines and Diagnostics S.r.l.

发明人： BERTI, Francesco

IPC分类号： A61K47/64 ,  A61K47/61 ,  A61K39/09 ,  A61P37/04

摘要： Three conjugation methods for use with the capsular saccharide of Streptococcus agalactiae. In the first method, reductive amination of oxidised sialic acid residue side chains is used, but the aldehyde groups are first aminated, and then the amine is coupled to a carrier via a linker. In the second method, sialic acid residues and/or N-acetyl-glucosamine residues are de-N-acetylated to give amine groups, and the amine groups are coupled to a carrier protein via a linker. In the third method, linkage is via galactose residues in the capsular saccharide rather than sialic acid residues, which can conveniently be achieved using galactose oxidase.

公开(公告)号：EP2552477B1

公开(公告)日：2019-05-15

申请号：EP11717765.9

申请日：2011-04-01

申请人： GlaxoSmithKline Biologicals S.A.

发明人： GRANDI, Guido ,  MAIONE, Domenico ,  RINUADO, Cira, Daniela

IPC分类号： A61K39/00 ,  C07K14/315 ,  C07K16/12 ,  A61K39/09