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公开(公告)号：EP3996707A1
公开(公告)日：2022-05-18
申请号：EP20836794.6
申请日：2020-07-07
IPC分类号： A61K31/415 , A61P7/02 , A61P7/04 , A61P7/10 , C07D231/14
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公开(公告)号：EP2051707A4
公开(公告)日：2011-04-27
申请号：EP07799928
申请日：2007-07-30
发明人： SINHA SUKANTO , CHILCOTE TAMIE JO
IPC分类号： A61K31/165 , A61K31/341 , A61K31/381 , A61K31/40 , A61K31/415 , A61K31/44 , A61K39/395 , A61P1/00 , A61P3/00 , A61P9/00 , C07C233/57
CPC分类号： C07D207/34 , C07D209/42 , C07D231/14 , C07D249/04 , C07D307/68 , C07D333/38 , C07D333/68 , C07D401/06
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公开(公告)号：EP2512466A4
公开(公告)日：2013-07-03
申请号：EP10838317
申请日：2010-12-17
发明人： SINHA SUKANTO , CHILCOTE TAMIE JO
IPC分类号： A61K31/34 , A61P7/02 , C07D207/34 , C07D231/14 , C07D403/10 , C07D417/04
CPC分类号： C07D207/34 , C07D231/14 , C07D401/14 , C07D403/10 , C07D417/04
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公开(公告)号：EP2259679A4
公开(公告)日：2011-09-14
申请号：EP09706933
申请日：2009-01-30
IPC分类号： A01N43/42
CPC分类号： A61K31/4439 , A61K31/341 , A61K31/343 , A61K31/381 , A61K31/40 , A61K31/402 , A61K31/404 , A61K31/415 , A61K31/4192 , A61K31/426 , A61K31/4436
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公开(公告)号：EP2697196A1
公开(公告)日：2014-02-19
申请号：EP12723771.7
申请日：2012-04-12
IPC分类号： C07D207/34 , C07D231/14 , A61K31/402 , A61K31/415 , A61P9/10
CPC分类号： C07D207/34 , C07D231/14
摘要： This invention provides new pharmaceutically useful compounds that are prodrugs of inhibitors of plasma kallikrein and methods and compositions for preventing or treating plasma kallikrein dependent diseases or conditions, such as diabetic macular edema or hemorrhagic stroke.
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公开(公告)号：EP2051707B1
公开(公告)日：2013-07-17
申请号：EP07799928.2
申请日：2007-07-30
IPC分类号： C07D207/34 , C07D209/42 , C07D231/14 , C07D249/04 , C07D307/68 , C07D333/38 , C07D333/68 , C07D401/06
CPC分类号： C07D207/34 , C07D209/42 , C07D231/14 , C07D249/04 , C07D307/68 , C07D333/38 , C07D333/68 , C07D401/06
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公开(公告)号：EP3997060A1
公开(公告)日：2022-05-18
申请号：EP20837750.7
申请日：2020-07-07
IPC分类号： C07C257/10 , A61K31/415 , C07B31/00 , C07C259/12 , C07D231/14
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公开(公告)号：EP2512466A1
公开(公告)日：2012-10-24
申请号：EP10838317.5
申请日：2010-12-17
发明人： SINHA, Sukanto , CHILCOTE, Tamie Jo
IPC分类号： A61K31/34
CPC分类号： C07D207/34 , C07D231/14 , C07D401/14 , C07D403/10 , C07D417/04
摘要： The present invention provides prodrugs of compounds that inhibit the activity of plasma kallikrein (PK) and methods of preventing and treating plasma kallikrein dependent diseases or conditions, for example, diabetic macular edema, with the prodrugs having the formula (I).
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公开(公告)号：EP2259679A1
公开(公告)日：2010-12-15
申请号：EP09706933.0
申请日：2009-01-30
IPC分类号： A01N43/42
CPC分类号： A61K31/4439 , A61K31/341 , A61K31/343 , A61K31/381 , A61K31/40 , A61K31/402 , A61K31/404 , A61K31/415 , A61K31/4192 , A61K31/426 , A61K31/4436
摘要： We have identified classes of kallikrein inhibitors as compounds that are useful in the reduction of vascular permeability (e.g., retinal vascular permeability and cerebral vascular permeability) and astrocyte activation. Diseases and conditions associated with increased vascular permeability include diabetic retinopathy, hemorrhagic stroke, and macular edema. Diseases and conditions associated with astrocyte activation include Alzheimer's disease, multiple sclerosis, Parkinson's disease, amyotrophic lateral sclerosis, Creutzfeldt- Jakob disease, stroke, epilepsy, and brain trauma.
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公开(公告)号：EP2051707A2
公开(公告)日：2009-04-29
申请号：EP07799928.2
申请日：2007-07-30
IPC分类号： A61K31/165 , A61K31/341 , A61K31/381 , A61K31/40 , A61K31/415 , A61K31/44 , A61K39/395 , A61P1/00 , A61P3/00 , A61P9/00 , C07C233/57
CPC分类号： C07D207/34 , C07D209/42 , C07D231/14 , C07D249/04 , C07D307/68 , C07D333/38 , C07D333/68 , C07D401/06
摘要： The present invention provides compounds that inhibit the activity of plasma kallikrein (PK) and methods of preventing and treating the formation of thrombin during or after a PK dependent disease or condition, for example, after fibrinolysis treatment.
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