公开(公告)号：EP3247362A1

公开(公告)日：2017-11-29

申请号：EP15861014.7

申请日：2015-11-16

申请人： Arno Therapeutics, Inc.

发明人： ZUKIWSKI, Alexander ,  PRONIUK, Stefan

IPC分类号： A61K31/56

CPC分类号： A61K9/20 ,  A61K31/575

摘要： Onapristone extended-release formulations and methods of administering onapristone extended-release formulations are provided. Onapristone extended-release formulations provide sufficient therapeutic activity as compared to immediate-release formulations with reduced potential for adverse side effects. Aspects described herein provide extended-release pharmaceutical compositions comprising onapristone as the active ingredient in an amount from about 2 mg to about 100 mg. The extended-release pharmaceutical compositions (also referred to herein as ER formulations) further comprise excipients suitable for the desired dosage form (e.g., tablet, capsule, etc.) and for delaying the release of the active ingredient.

公开(公告)号：EP3129786A1

公开(公告)日：2017-02-15

申请号：EP15776251.9

申请日：2015-04-07

申请人： Arno Therapeutics Inc. ,  Invivis Pharmaceuticals Inc.

发明人： GILLES, Erard ,  ZUKIWSKI, Alexander

IPC分类号： G01N33/574

CPC分类号： G01N33/57415 ,  G01N2333/723

摘要： Systems and methods for identifying progesterone positive tumors utilizing progesterone receptor isotype-specific antibodies are provided.

摘要翻译： 提供了用于鉴定孕激素阳性肿瘤利用孕激素受体同种型特异性抗体的系统和方法。

公开(公告)号：EP3250553A1

公开(公告)日：2017-12-06

申请号：EP16744061.9

申请日：2016-01-27

申请人： Arno Therapeutics, Inc. ,  Ohio State Innovation Foundation

发明人： SCHLESINGER, Larry ,  YOUNT, Jacob ,  ZUKIWSKI, Alexander ,  PRONIUK, Stefan ,  TUÑÓN, María Jesús ,  ZANDI, Keivan

IPC分类号： C07D231/12 ,  C07D403/10

CPC分类号： A61K31/415 ,  A61K45/06 ,  Y02A50/385 ,  Y02A50/387 ,  Y02A50/393

摘要： Compositions and methods for inhibiting viral protein production, viral infection, and viral replication in a host or host cells infected with a virus (e.g., influenza, Junin, Chikungunya, Dengue, HIV, RHDV) by administering AR-12 and AR-12 analogs are provided.

公开(公告)号：EP3129786A4

公开(公告)日：2018-03-14

申请号：EP15776251

申请日：2015-04-07

申请人： ARNO THERAPEUTICS INC ,  INVIVIS PHARMACEUTICALS INC

发明人： GILLES ERARD ,  ZUKIWSKI ALEXANDER

IPC分类号： G01N33/574

CPC分类号： G01N33/57415 ,  G01N2333/723

摘要： Systems and methods for identifying progesterone positive tumors utilizing progesterone receptor isotype-specific antibodies are provided.

公开(公告)号：EP3244888A1

公开(公告)日：2017-11-22

申请号：EP16737641.7

申请日：2016-01-07

申请人： Arno Therapeutics, Inc. ,  Ohio State Innovation Foundation

发明人： RAPPLEYE, Chad ,  ZUKIWSKI, Alexander ,  PRONIUK, Stefan

IPC分类号： A61K31/415

CPC分类号： A61K31/415 ,  A61K31/4196 ,  A61K45/06 ,  A61P31/10 ,  A61K2300/00

摘要： Compositions and methods for inhibiting fungal growth by administering AR-12 to a host infected with a fungus such as Histoplasma capsulatum, Aspergillus fumigatus, and Trichophyton rubrum, Paecilomyces, Rhizopus, Fusarium, Scedosporium, Lomentospora, Apophysomyces, Coccidioides, Blastomyces, non-albicans Candida, and Pneumocytis are provided.