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公开(公告)号：EP1162955B1
公开(公告)日：2005-06-15
申请号：EP00922528.5
申请日：2000-03-17
申请人： INSTITUT FÜR NEUE MATERIALIEN GEM. GMBH , Across Barriers Gesellschaft für neue Technologien zur Absorption und Applikation von Arzneistoffen MBH
发明人： SCHIESTEL, Thomas , SCHIRRA, Hermann , SCHMIDT, Helmut , LEHR, Claus-Michael , HALTNER, Eleonore , KNEUER, Carsten , SAMETI, Mohammad
CPC分类号： A61K9/5115 , A61K47/62 , A61K47/6923 , A61K47/6929 , A61K48/00 , B82Y5/00 , C12N15/88 , C12Q2563/155
摘要： The invention relates to nanoparticles with a core of inorganic primary particles the surface of which is completely or partially covered by a coating by reacting them with organosilane or polyorganosilane that contains functional groups. The particles have a zeta potential of 0 to + 100 mV in a neutral pH range of 7.0 to 7.5. The nanoparticles form nanoparticle-polynucleotide complexes with polynucleotides (for example DNA). Said nanoparticle-polynucleotide complexes are used to transfect target cells or for gene therapy.
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公开(公告)号：EP1162955A1
公开(公告)日：2001-12-19
申请号：EP00922528.5
申请日：2000-03-17
申请人： INSTITUT FÜR NEUE MATERIALIEN GEM. GMBH , Across Barriers Gesellschaft für neue Technologien zur Absorption und Applikation von Arzneistoffen MBH
发明人： SCHIESTEL, Thomas , SCHIRRA, Hermann , SCHMIDT, Helmut , LEHR, Claus-Michael , HALTNER, Eleonore , KNEUER, Carsten , SAMETI, Mohammad
CPC分类号： A61K9/5115 , A61K47/62 , A61K47/6923 , A61K47/6929 , A61K48/00 , B82Y5/00 , C12N15/88 , C12Q2563/155
摘要： The invention relates to nanoparticles with a core of inorganic primary particles the surface of which is completely or partially covered by a coating by reacting them with organosilane or polyorganosilane that contains functional groups. The particles have a zeta potential of 0 to + 100 mV in a neutral pH range of 7.0 to 7.5. The nanoparticles form nanoparticle-polynucleotide complexes with polynucleotides (for example DNA). Said nanoparticle-polynucleotide complexes are used to transfect target cells or for gene therapy.
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