公开(公告)号：EP1791859A1

公开(公告)日：2007-06-06

申请号：EP05783052.3

申请日：2005-09-02

申请人： Alcami Pertejo, Antonio

发明人： ALEJO HERBERG, Ali ,  RUIZ-ARGUELLO, Maria Begoña ,  HO, Yin ,  SARAIVA, Margarida ,  SMITH, Vicent, P.

IPC分类号： C07K14/065 ,  G01N33/50 ,  C12N15/62 ,  A61K38/16 ,  C12N15/39

CPC分类号： C07K14/70578 ,  C07K14/005 ,  C07K2319/32 ,  C12N2710/14143 ,  C12N2710/24122 ,  G01N2333/70578

摘要： Chemokine binding activity of viral TNF receptors and related proteins. The invention relates to a C-terminal domain (CTD) of viral tumour necrosis factor receptors (vTNFRs) CrmB or CrmD or CTD homologues (CTD1, CTD2 and CTD3) from poxvirus and their functional homologues, including derivatives, and fragments, for use in binding chemokines and their analogues and/or to enhance the immunomodulatory properties of TNFRs or in bloking binding of chemokines to their corresponding cell surface receptors and/or to modulate chemokine biological activity.