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    NUCLEIC ACID NANOPARTICLES AND USES THEREFOR
    6.
    发明公开
    NUCLEIC ACID NANOPARTICLES AND USES THEREFOR 有权
    NUKLEINSÄURE-NANOTEILCHEN UND IHRE VERWENDUNGSZWECKE

    公开(公告)号：EP2162117A2

    公开(公告)日：2010-03-17

    申请号：EP08756527.1

    申请日：2008-05-30

    申请人： Anterios, Inc.

    发明人： EDELSON, Jonathan ,  KOTYLA, Timothy ,  ZHANG, Boke

    IPC分类号： A61K9/107 ,  A61K9/51 ,  A61K31/7105

    CPC分类号： A61K31/7105 ,  A61K9/0014 ,  A61K9/1075

    摘要： The present invention provides nanoparticle compositions including one or more nucleic acids. The present invention achieves delivery (particularly transdermal delivery) of such nucleic acids without the need for nucleic acid modification, or for use of chemical or mechanical abrasion or disruption of skin.

    摘要翻译： 本发明提供包含一种或多种核酸的纳米颗粒组合物。 本发明实现了这种核酸的递送（特别是透皮递送），而不需要核酸修饰，或者用于化学或机械磨损或皮肤破坏。

    DERMAL DELIVERY
    7.
    发明公开
    DERMAL DELIVERY 审中-公开

    公开(公告)号：EP3650017A1

    公开(公告)日：2020-05-13

    申请号：EP19197619.0

    申请日：2009-06-26

    申请人： Anterios, Inc.

    发明人： ZHANG, Boke ,  KOTYLA, Timothy ,  EDELSON, Jonathan

    IPC分类号： A61K9/51 ,  A61K31/48

    摘要： The present invention describes systems and methods for treating disorders and/or conditions associated with the dermal level of the skin. Such disorders include acne, hyperhidrosis, bromhidrosis, chromhidrosis, rosacea, hair loss, dermal infection, and/or actinic keratosis. Methods generally involve administering nanoemulsions ( e.g ., nanoparticle compositions) comprising at least one therapeutic agent, such as botulinum toxin. In some embodiments, nanoemulsions are prepared, e.g., by high pressure microfluidization, and comprise a particle size distribution exclusively between 10 nm and 300 nm.

    OIL COMPOSITIONS
    9.
    发明公开
    OIL COMPOSITIONS 审中-公开
    油组合物

    公开(公告)号：EP2667945A1

    公开(公告)日：2013-12-04

    申请号：EP12702931.2

    申请日：2012-01-23

    申请人： Anterios, Inc.

    发明人： EDELSON, Jonathan ,  KOTYLA, Timothy ,  THEOBALD, Klaus

    IPC分类号： A61P17/10 ,  A61K31/20

    CPC分类号： A61K31/20

    摘要： The present invention provides oil compositions and associated methods and reagents, particularly useful for the treatment of dermatologic conditions. In some embodiments, provided compositions are formulated for and achieve transdermal delivery, for example by topical administration.

    DERMAL DELIVERY
    10.
    发明公开
    DERMAL DELIVERY 有权
    DERMALE VERABREICHUNG

    公开(公告)号：EP2310000A1

    公开(公告)日：2011-04-20

    申请号：EP09771218.6

    申请日：2009-06-26

    申请人： Anterios, Inc.

    发明人： EDELSON, Jonathan ,  KOTYLA, Timothy ,  ZHANG, Boke

    IPC分类号： A61K9/51 ,  A61K31/48

    摘要： The present invention describes systems and methods for treating disorders and/or conditions associated with the dermal level of the skin. Such disorders include acne, hyperhidrosis, bromhidrosis, chromhidrosis, rosacea, hair loss, dermal infection, and/or actinic keratosis. Methods generally involve administering nanoemulsions (e.g., nanoparticle compositions) comprising at least one therapeutic agent, such as botulinum toxin. In some embodiments, nanoemulsions are prepared, e.g., by high pressure microfluidization, and comprise a particle size distribution exclusively between 10 nm and 300 nm.

    摘要翻译： 本发明描述了用于治疗与皮肤皮肤水平相关的病症和/或病症的系统和方法。 这些病症包括痤疮，多汗症，异色汗菌，色泽病，红斑痤疮，脱发，皮肤感染和/或光化性角化病。 方法通常包括施用包含至少一种治疗剂如肉毒杆菌毒素的纳米乳剂（例如，纳米颗粒组合物）。 在一些实施方案中，例如通过高压微流化制备纳米乳剂，并且包含仅在10nm和300nm之间的粒度分布。