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公开(公告)号:EP3206719B1
公开(公告)日:2020-04-08
申请号:EP15850028.0
申请日:2015-10-15
申请人: City of Hope , Apterna Ltd
发明人: ROSSI, John J. , YOON, Sorah , HABIB, Nagy
IPC分类号: C12N15/115 , A61K48/00 , C07H21/02
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公开(公告)号:EP3416690A1
公开(公告)日:2018-12-26
申请号:EP17753895.6
申请日:2017-02-17
申请人: City of Hope , Apterna Ltd
发明人: ROSSI, John, J. , YOON, Sorah , HABIB, Nagy
IPC分类号: A61K49/00 , C12N15/09 , C12N15/115 , C12Q1/68
CPC分类号: C12N15/115 , C12N2310/16 , C12N2310/318 , C12N2310/3519 , C12N2310/51 , C12N2310/321 , C12N2310/3521 , C12N2310/322 , C12N2310/3533
摘要: Provided are aptamers and aptamer compositions and particularly, although not exclusively, to a bi-specific aptamer capable of binding a tumor cell antigen and an immune cell surface protein.
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公开(公告)号:EP3206719A4
公开(公告)日:2018-01-17
申请号:EP15850028
申请日:2015-10-15
申请人: HOPE CITY , APTERNA LTD
发明人: ROSSI JOHN J , YOON SORAH , HABIB NAGY
CPC分类号: C12N15/115 , C07K14/70582 , C12N2310/16 , C12N2310/351 , C12N2310/3519 , C12N2310/322 , C12N2310/3533
摘要: Provided herein, inter alia, are nucleic acid compounds capable of binding transferrin receptor on a cell and internalizing into said cell. The compositions provided herein may be useful for delivering therapeutic and diagnostic agents to a cell. Further provided are pharmaceutical compositions and methods of treatment using nucleic acid compounds provided herein.
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公开(公告)号:EP3206719A1
公开(公告)日:2017-08-23
申请号:EP15850028.0
申请日:2015-10-15
申请人: City of Hope , Apterna Ltd
发明人: ROSSI, John J. , YOON, Sorah , HABIB, Nagy
CPC分类号: C12N15/115 , A61K31/7105 , A61K31/713 , A61K45/06 , A61K47/549 , C07K14/70582 , C12N2310/16 , C12N2310/351 , C12N2310/3519 , C12N2320/31 , G01N33/5308 , G01N33/57492 , G01N2333/70582 , C12N2310/322 , C12N2310/3533
摘要: Provided herein, inter alia, are nucleic acid compounds capable of binding transferrin receptor on a cell and internalizing into said cell. The compositions provided herein may be useful for delivering therapeutic and diagnostic agents to a cell. Further provided are pharmaceutical compositions and methods of treatment using nucleic acid compounds provided herein.
摘要翻译: 本文提供的是特别是能够结合细胞上的运铁蛋白受体并内化到所述细胞中的核酸化合物。 本文提供的组合物可用于将治疗剂和诊断剂递送至细胞。 进一步提供了使用本文提供的核酸化合物的药物组合物和治疗方法。
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