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公开(公告)号：EP2269663A2
公开(公告)日：2011-01-05
申请号：EP10159575.9
申请日：2010-04-11
CPC分类号： A61L27/46 , A61L2430/02
摘要： A bone graft or biocomposite for treating osseous defects and neogenesis of bone which is a composite of a biodegradable polymer and granules of beta-tricalciumphosphate, further comprising as active ingredient and embedded in the biodegradable polymer a physiologically effective amount of underglycosylated recombinant human BSP as a mutidental clathrate with a basic organic compound which simulataneously is active as a plasticizer for the biodegradable polymer. The biocomposite is moldable and shapable, hardens rapidly in situ when placed by surgery or prosthetic dentistry and which furthers osseous repair and the healing of damage or diseased tissues and lesions.
摘要翻译： 一种骨移植物或生物复合物，用于治疗作为生物可降解聚合物和β-磷酸三钙颗粒的复合物的骨的骨缺陷和新生，其还包含作为活性成分并包埋在生物可降解聚合物中的生理有效量的低糖基化重组人BSP，作为 与含有基本有机化合物的多齿包合物同时作为生物可降解聚合物的增塑剂起作用。 该生物复合材料是可模塑和可成形的，当通过手术或假牙牙科学放置时可迅速原位硬化，并促进骨修复和损伤或患病组织和病变的愈合。
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2.发明授权
公开(公告)号：EP1399186B1
公开(公告)日：2009-11-18
申请号：EP02748771.9
申请日：2002-06-12
发明人： ARMBRUSTER, Franz, Paul , KARMATSCHEK, Markus , NADER, Werner, Franz , FORSMANN, Ulf, Jörg , PAULSSON, Mats, Inst.für Biochemie, Mediz.Fakultät , BERGER, Martin, R.
IPC分类号： A61K39/395
CPC分类号： C07K16/18 , A01K2217/05 , A61K2039/505 , C07K14/51 , C07K2317/11 , C07K2317/21
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3.发明公开
公开(公告)号：EP1678302A1
公开(公告)日：2006-07-12
申请号：EP04786905.2
申请日：2004-09-01
申请人： Deutsches Krebsforschungszentrum Stiftung des Öffentlichen Rechts , Armbruster Biotechnology GmbH
IPC分类号： C12N15/11 , C07H21/00 , A61K31/711 , A61K31/00 , A61P35/04
CPC分类号： C12N15/113 , A61K31/711 , A61K38/00 , C07H21/00 , C12N15/1135 , C12N15/1136 , C12N2310/11 , C12N2310/111 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/346 , C12N2310/3525
摘要： Described are antisense oligonucleotides targeted to the gene encoding osteopontin, bone sialoprotein II and/or osteonectin, wherein said oligonucleotides inhibit the expression of said gene(s). Moreover, the therapeutic use of said antisense oligonucleotides is described, e.g., for the treatment or prevention of cancer/metastasis, preferably osteolytic metastasis or metastasis of breast cancer cells.
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公开(公告)号：EP2448609A2
公开(公告)日：2012-05-09
申请号：EP10741920.2
申请日：2010-07-05
CPC分类号： A61L27/46 , A61L2430/02
摘要： A bone graft or biocomposite for treating osseous defects and neogenesis of bone which is a composite of a biodegradable polymer and granules of beta-tricalciumphosphate, further comprising as active ingredient and embedded in the biodegradable polymer a physiologically effective amount of underglycosylated recombinant human BSP as a mutidental clathrate with a basic organic compound which simulataneously is active as a plasticizer for the biodegradable polymer. The biocomposite is moldable and shapable, hardens rapidly in situ when placed by surgery or prosthetic dentistry and which furthers osseous repair and the healing of damage or diseased tissues and lesions.
摘要翻译： 一种骨移植物或生物复合物，用于治疗作为生物可降解聚合物和β-磷酸三钙颗粒的复合物的骨的骨缺陷和新生，其还包含作为活性成分并包埋在生物可降解聚合物中的生理有效量的低糖基化重组人BSP，作为 与含有基本有机化合物的多齿包合物同时作为生物可降解聚合物的增塑剂起作用。 该生物复合材料是可模塑和可成形的，当通过手术或假牙牙科学放置时可迅速原位硬化，并促进骨修复和损伤或患病组织和病变的愈合。
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公开(公告)号：EP2269663A3
公开(公告)日：2011-04-06
申请号：EP10159575.9
申请日：2010-04-11
CPC分类号： A61L27/46 , A61L2430/02
摘要： A bone graft or biocomposite for treating osseous defects and neogenesis of bone which is a composite of a biodegradable polymer and granules of beta-tricalciumphosphate, further comprising as active ingredient and embedded in the biodegradable polymer a physiologically effective amount of underglycosylated recombinant human BSP as a mutidental clathrate with a basic organic compound which simulataneously is active as a plasticizer for the biodegradable polymer. The biocomposite is moldable and shapable, hardens rapidly in situ when placed by surgery or prosthetic dentistry and which furthers osseous repair and the healing of damage or diseased tissues and lesions.
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公开(公告)号：EP2269663B1
公开(公告)日：2018-03-07
申请号：EP10159575.9
申请日：2010-04-11
CPC分类号： A61L27/46 , A61L2430/02
摘要： A bone graft or biocomposite for treating osseous defects and neogenesis of bone which is a composite of a biodegradable polymer and granules of beta-tricalciumphosphate, further comprising as active ingredient and embedded in the biodegradable polymer a physiologically effective amount of underglycosylated recombinant human BSP as a mutidental clathrate with a basic organic compound which simulataneously is active as a plasticizer for the biodegradable polymer. The biocomposite is moldable and shapable, hardens rapidly in situ when placed by surgery or prosthetic dentistry and which furthers osseous repair and the healing of damage or diseased tissues and lesions.
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公开(公告)号：EP2448609B1
公开(公告)日：2014-10-08
申请号：EP10741920.2
申请日：2010-07-05
CPC分类号： A61L27/46 , A61L2430/02
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