公开(公告)号：EP2726110A4

公开(公告)日：2015-07-01

申请号：EP12807128

申请日：2012-07-01

申请人： MILLWARD NIKI ZACHARIAS ,  BHATTACHARYA PRATIP

发明人： MILLWARD NIKI ZACHARIAS ,  BHATTACHARYA PRATIP

IPC分类号： A61K49/10 ,  C07C69/40 ,  C07C69/60 ,  G01R33/46 ,  G01R33/56

CPC分类号： A61K49/10 ,  C07C69/40 ,  C07C69/60 ,  G01R33/46 ,  G01R33/5601

公开(公告)号：EP2726110A1

公开(公告)日：2014-05-07

申请号：EP12807128.9

申请日：2012-07-01

申请人： Millward, Niki, Zacharias ,  Bhattacharya, Pratip

发明人： Millward, Niki, Zacharias ,  Bhattacharya, Pratip

IPC分类号： A61K49/10

CPC分类号： A61K49/10 ,  C07C69/40 ,  C07C69/60 ,  G01R33/46 ,  G01R33/5601

摘要： The present embodiments disclose the preparation of hyperpolarized 13C dialkyi succinate compounds and hyperpolarized 13C dialkyi fumarate compounds and their use in real time, in vivo metabolic imaging of the TCA cycle. In another embodiment, a composition is provided, the composition comprising hyperpolarized diethyl 1-
13 C succinate and diethyl 1,4-
13 C succinate.