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    Movement-responsive system for conducting tests on freely-moving animals
    6.
    发明公开
    Movement-responsive system for conducting tests on freely-moving animals 失效
    在对能动的运行测试运动响应系统

    公开(公告)号：EP0872179A2

    公开(公告)日：1998-10-21

    申请号：EP97310046.4

    申请日：1997-12-12

    申请人： Bioanalytical Systems, Inc

    发明人： Kissinger, Candice B. ,  Bohs, Curtis E. ,  Schmidt, William J. ,  Evans, Donnie A.

    IPC分类号： A01K29/00 ,  A01K1/03

    CPC分类号： A01K29/005 ,  A01K1/031 ,  A61B5/1105 ,  A61B2503/40 ,  A61B2503/42 ,  A61B2562/221

    摘要： A movement-responsive system (10) for conducting tests on freely-moving animals is disclosed. The invention includes a container (14) for housing the animal (12), a mechanism (16) for rotating the cage (14) in response to rotational movement of the animal and one or more test leads (18,20,22,24) connected to the animal for performance of biomedical tests such as infusion, in vivo ultrafiltration, laser-doppler monitoring of blood flow, electrical stimulation and in vivo microdialysis. The container (14) is caused to rotate in the opposite (counter-rotation) direction of the sensed direction of rotation of the animal (12) so that the one or more test leads (18,20,22,24) do not become entangled, twisted, disconnected, or clamped. The rotating mechanism includes a simple, reliable sensor assembly (32) including a pair of strategically placed, close-ended limit detectors (70,72) which are activated by a triggering element (84) which is also a part of the sensor assembly. The sensor assembly is mounted on a counter-balanced arm (38) which is responsive to upward and downward movements of the animal (12). No complex control system is required for the present invention yet adjustment of the sensitivity of the rotating mechanism is easy to accomplish and may be performed by the average user of the apparatus. Further, the leads may all be continuous, thereby eliminating problems caused by the use of liquid swivels with independently rotating halves or by commutator connectors.

    摘要翻译： 用于进行上自由移动的动物试验甲运动应答系统（10）被盘游离缺失。 本发明包括用于容纳动物（12），机构（16），用于旋转所述笼（14）的容器（14）（响应于动物的旋转运动和一个或多个测试导线18,20,22,24 ）连接到所述动物为生物医学测试性能：如输液，超滤中的血流量，电刺激体内激光多普勒监测和体内微透析。 所述容器（14）引起的，在动物（12）的旋转所感测的方向相反的（反向旋转）方向旋转所做的一个或多个测试引线（18,20,22,24），不会成为 纠缠，扭曲，断开或夹紧。 旋转机构包括一个简单的，可靠的传感器组件（32）包括一对由因此其是传感器组件的一部分的触发元件（84）所有的激活策略地放置，封闭式限制检测器（70,72）的。 该传感器组件被安装在反平衡臂（38）的所有其响应于所述动物（12）的向上和向下运动。 没有复杂的控制系统是所必需的旋转机构的灵敏度，本发明还调整是容易实现，并且可以由装置的一般用户来执行。 此外，引线可以全部是连续的，从而消除了通过使用液体引起的问题与unabhängig旋转halves或通过换向器连接器转环。

    Movement-responsive system for conducting tests on freely-moving animals
    10.
    发明公开
    Movement-responsive system for conducting tests on freely-moving animals 有权
    在对能动的运行测试运动响应系统

    公开(公告)号：EP0986951A3

    公开(公告)日：2001-06-27

    申请号：EP99307384.0

    申请日：1999-09-17

    申请人： Bioanalytical Systems, Inc

    发明人： Kissinger, Candice B. ,  Schmidt, William J. ,  Evans, Donnie A. ,  Peters, Scott R. ,  Hampsch, James M. ,  Bohs, Curtis E. ,  Gunaratna, W. Gamini

    IPC分类号： A01K29/00 ,  A01K1/03

    CPC分类号： A61B5/1105 ,  A01K1/031 ,  A01K23/005 ,  A01K29/005 ,  A61B5/15003 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150236 ,  A61B5/150244 ,  A61B5/150992 ,  A61B5/153 ,  A61B10/0038 ,  A61B10/007 ,  A61B2503/40 ,  A61B2503/42 ,  A61B2562/221

    摘要： A movement-responsive system for conducting tests on freely-moving animals is disclosed. The invention includes a container (14) for housing the animal, a mechanism for rotating the container in response to rotational movement of the animal, and one or more test leads (18,20,22,24) connected to the animal for performance of biomedical tests such as infusion, in vivo ultrafiltration, laser-doppler monitoring of blood flow, electrical stimulation and in vivo microdialysis, and a method for automated micro sampling of body fluids in free-moving animals. Because the cage (14) is rotated in response to the animal's rotational movement, no swivel connectors are needed. A rotational sensor assembly (32) is provided to detect rotational movement of the animal within the container (14). A vertical sensor assembly is mounted to the counterbalanced arm for monitoring vertical movements of the animal. The outputs of the sensor assemblies (32) are routed to a computer or other device for monitoring and/or analyzing the activity of the animal. The container (14) is configured to act as an operant chamber or a metabolic chamber by locating a hole in the bottom of the container and through the rotating mechanism. The invention also enables a new method for sampling body fluids of the animal without restricting the animal's movement. The sampling method uses a syringe pump (40,42,44) to result in high fidelity fluid control greatly increasing repeatability of experiments. Further, the method employs pinch valves (182) to control fluid flow in conjunction with an anticoagulant coated tubing, thereby resulting in a blood sampling method that does not require the use of heparinized sterile saline solution as a wash fluid.