-
公开(公告)号：EP4396203A1
公开(公告)日：2024-07-10
申请号：EP22783229.2
申请日：2022-09-02
发明人： COLOSI, Peter , LEONARD, Vincent , RAMIREZ, Silvia , ISHIDA, Justin , TSENG, Yu-shan , STERLING, Teague
IPC分类号： C07K14/005
-
公开(公告)号：EP4275751A2
公开(公告)日：2023-11-15
申请号：EP23188800.9
申请日：2017-02-24
IPC分类号： A61P25/28
摘要： The present disclosure relates in general to therapeutic lysosomal enzyme fusion proteins useful for treating lyso-somal storage diseases, liquid formulations comprising such fusion proteins and associated methods useful for treating lysosomal storage diseases in mammals.
-
公开(公告)号：EP4103699A1
公开(公告)日：2022-12-21
申请号：EP21709585.0
申请日：2021-02-09
发明人： LOCHRIE, Michael , COLOSI, Peter , CARTER, Barrie , CINEK, Tomas
IPC分类号： C12N7/00
-
公开(公告)号：EP4029512A1
公开(公告)日：2022-07-20
申请号：EP21211450.8
申请日：2010-05-20
发明人： WENDT, Daniel, J. , AOYAGI-SCHARBER, Mika , LONG, Shinong , VELLARD, Michel, Claude , CASTILLO, Sianna , OKHAMAFE, Augustus, O. , PRICE, Christopher, P.
IPC分类号： A61K38/00 , A61P9/00 , A61P9/12 , A61P13/12 , A61P19/00 , C07K14/58 , A61K38/22 , A61P9/10 , A61P9/04 , A61P19/08 , A61K47/60 , A61P7/10 , A61P21/00
摘要： The present disclosure provides variants of C-type natriuretic peptide (CNP), pharmaceutical compositions comprising CNP variants, and methods of making CNP variants. The CNP variants are useful as therapeutic agents for the treatment of diseases responsive to CNP, including but not limited to bone-related disorders, such as skeletal dysplasias (e.g., achondroplasia), and vascular smooth muscle disorders (e.g., restenosis and arteriosclerosis).
-
公开(公告)号：EP3969061A1
公开(公告)日：2022-03-23
申请号：EP20729502.3
申请日：2020-05-13
发明人： COLOSI, Peter , ISHIDA, Justin , RAMIREZ, Silvia
IPC分类号： A61K48/00
-
公开(公告)号：EP3778652A1
公开(公告)日：2021-02-17
申请号：EP20184387.7
申请日：2009-05-07
发明人： LEBOWITZ, JONATHAN , MAGA, JOHN
IPC分类号： C07K19/00 , C07K14/475
摘要： The present invention provides further improved compositions and methods for efficient lysosomal targeting based on the GILT technology. Among other things, the present invention provides methods and compositions for targeting lysosomal enzymes to lysosomes using furin-resistant lysosomal targeting peptides. The present invention also provides methods and compositions for targeting lysosomal enzymes to lysosomes using a lysosomal targeting peptide that has reduced or diminished binding affinity for the insulin receptor.
-
公开(公告)号：EP3044231B1
公开(公告)日：2020-08-05
申请号：EP14771729.2
申请日：2014-09-10
IPC分类号： C07K14/755 , A61K48/00 , C12N15/86
-
公开(公告)号：EP3524324A1
公开(公告)日：2019-08-14
申请号：EP18214838.7
申请日：2012-02-28
IPC分类号： A61P35/00 , C07D277/30 , C07D231/12 , C07D263/32 , C07D261/08 , C07D233/64 , C07D401/06 , A61K31/421 , A61K31/425 , A61K31/426 , A61K31/415 , A61K31/4164 , A61K31/454
摘要： This invention relates to generally inhibiting histone deacetylase ("HDAC") enzymes (e.g., HDAC1, HDAC2, and HDAC3).
-
9.发明公开
公开(公告)号：EP3479842A3
公开(公告)日：2019-07-17
申请号：EP18187522.0
申请日：2011-02-03
发明人： KAKKIS, Emil, D. , VELLARD, Michel Claude , WENDT, Daniel, J. , MUTHALIF, Mubarack , OKHAMAFE, Augustus O. , BELL, Sean M. , ZECHERLE, G. Nick , ANTONSEN, Kris , ZHANG, Yanhong , LY, Kieu Y. , FITZPATRICK, Paul A.
摘要： Provided are compositions comprising a recombinant phenylalanine ammonia-lyase (PAL) derived from the bacterial species Anabaena variabilis, Nostoc punctiforme, Streptomyces maritimus, Streptomyces verticillatus, Soragium cellulosum, Nostoc tobacum, or Pseudomonas putida, or a biologically active fragment, mutant, variant or analog thereof, and a pharmaceutically acceptable carrier. Further provided are such compositions of recombinant bacterial PAL and biologically active fragments, mutants, variants or analogs thereof for use in treating phenylketonuria hyperphenylalaninemia.
-
公开(公告)号：EP3491008A2
公开(公告)日：2019-06-05
申请号：EP17749265.9
申请日：2017-07-25
IPC分类号： C07K14/005 , C12N15/86 , A61K48/00
-
-
-
-
-
-
-
-
-
搜索结果
173 条记录 (耗时 0.024 秒)
