公开(公告)号：EP4426267A1

公开(公告)日：2024-09-11

申请号：EP22813973.9

申请日：2022-11-04

Applicant: Fondation A de Rothschild

Inventor： GABISON, Eric

IPC: A61K9/127 ,  A61K35/28 ,  A61P27/02

CPC classification number: A61P27/02 ,  A61K35/28 ,  A61K9/0048 ,  A61K9/1271 ,  C12N2740/1604320130101 ,  C12N15/88 ,  A61K48/005 ,  A61K48/0041 ,  A01K2227/10520130101 ,  A01K2217/07220130101 ,  A01K2267/0320130101

公开(公告)号：EP4413148A1

公开(公告)日：2024-08-14

申请号：EP22879412.9

申请日：2022-10-03

Applicant: Day, Alexander ,  Mullin, Bradford

Inventor： Day, Alexander ,  Mullin, Bradford

IPC: C12N15/88 ,  C07K14/51 ,  A61K38/18 ,  A61K48/00 ,  A61K47/69

CPC classification number: C12N15/88 ,  C07K14/51 ,  A61K48/0041 ,  A61K47/543

公开(公告)号：EP4396201A1

公开(公告)日：2024-07-10

申请号：EP22777930.3

申请日：2022-09-02

Applicant: BioMarin Pharmaceutical Inc.

Inventor： COLOSI, Peter ,  LEONARD, Vincent ,  RAMIREZ, Silvia ,  ISHIDA, Justin ,  TSENG, Yu-shan ,  STERLING, Teague

IPC: C07K14/005

CPC classification number: C07K14/005 ,  C12N15/86 ,  C12N2750/1412220130101 ,  C12N2750/1414320130101 ,  C12N2750/1414520130101 ,  A61K48/0041 ,  A61K48/0075

公开(公告)号：EP4380600A1

公开(公告)日：2024-06-12

申请号：EP22757593.3

申请日：2022-07-29

Applicant: Universidade de Santiago de Compostela ,  Centre National de la Recherche Scientifique (CNRS) ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  Université d'Angers

Inventor： MILBANK, Edward ,  LÓPEZ PÉREZ, Miguel Antonio ,  MARTINEZ MARTINEZ, María Del Carmen ,  ANDRIANTSITOHAINA, Ramaroson

IPC: A61K38/45 ,  A61P3/04 ,  A61K35/15 ,  C12N15/52 ,  C12N5/0784

CPC classification number: A61K38/45 ,  C12Y207/11026 ,  A61P3/04 ,  A61K35/15 ,  C12N5/0639 ,  A61K48/0041 ,  A01K2227/10520130101 ,  A01K2217/07520130101

公开(公告)号：EP4316588A3

公开(公告)日：2024-05-15

申请号：EP23202277.2

申请日：2017-05-26

Applicant: Transcriptx, Inc.

Inventor： LOCKHART, David J. ,  WUSTMAN, Brandon ,  HENNIG, Mirko ,  ISHIMARU, Daniella

IPC: A61K48/00 ,  A61K31/711 ,  A61K31/713 ,  A61K31/7105 ,  A61K31/7115 ,  A61P11/00 ,  A61P11/06 ,  C07K14/47

CPC classification number: A61K48/0041 ,  A61K48/005 ,  A61P11/06 ,  A61K31/7105 ,  A61K31/7115 ,  A61P11/00 ,  C07K14/47

Abstract: Polynucleotides encoding peptides, proteins, enzymes, and functional fragments thereof are disclosed. The polynucleotides of the disclosure can be effectively delivered to an organ, such as the lung, and expressed within cells of the organ. The polyribonucleotides of the disclosure can be used to treat a disease or condition associated with cilia maintenance and function, impaired function of the axoneme, such as DNAI1 or DNAH5.

公开(公告)号：EP3363447A1

公开(公告)日：2018-08-22

申请号：EP16855714.8

申请日：2016-10-12

Applicant: Industry - University Cooperation Foundation Hanyang University

Inventor： YUN, Chae Ok ,  NA, Youjin

IPC: A61K35/761 ,  A61K38/00

CPC classification number: A61K48/0041 ,  A61K35/761 ,  A61K38/00 ,  A61P35/00

Abstract: The present invention relates to an adenovirus complex which can be utilized for gene transfer and gene therapy by targeting neurotensin receptors. The complex of the present invention has an excellent antitumor effect because of a high intracellular gene transfer efficiency and target specificity by neurotensin receptor-specific binding, has little hepatotoxicity and immunogenicity, forms a stable complex, has low immunogenicity, and thus has a low loss in blood even in an in vivo environment. Therefore, the complex of the present invention can be effectively used for gene therapy.

公开(公告)号：EP3326641A1

公开(公告)日：2018-05-30

申请号：EP17196250.9

申请日：2016-04-22

Applicant: CureVac AG

Inventor： Fotin-Mleczek, Mariola ,  Kowalczyk, Aleksandra ,  Heidenreich, Regina ,  Baumhof, Patrick ,  Probst, Jochen ,  Kallen, Karl-Josef

IPC: A61K38/19 ,  C07K14/52 ,  A61K38/20 ,  A61K39/00 ,  C12N15/113 ,  C12N15/117 ,  A61P35/00

CPC classification number: A61K48/005 ,  A61K9/0019 ,  A61K31/7105 ,  A61K31/713 ,  A61K38/177 ,  A61K38/1774 ,  A61K38/19 ,  A61K38/208 ,  A61K39/12 ,  A61K39/145 ,  A61K39/39 ,  A61K39/3955 ,  A61K39/39558 ,  A61K45/06 ,  A61K48/0041 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/55511 ,  A61K2039/55522 ,  A61K2039/55538 ,  A61K2039/55561 ,  A61K2039/585 ,  C07K16/2818 ,  C07K16/2878 ,  C07K16/2896 ,  C07K16/30 ,  C07K16/34 ,  C07K2317/75 ,  C07K2317/76 ,  C12N7/00 ,  C12N15/117 ,  C12N2310/17 ,  C12N2320/30 ,  C12N2760/16034 ,  C12N2760/16134 ,  Y02A50/386 ,  Y02A50/388 ,  Y02A50/39 ,  Y02A50/394 ,  Y02A50/397 ,  A61K2300/00

Abstract: The present invention relates to RNA containing compositions for use in the treatment or prophylaxis of tumor and/or cancer diseases, to a pharmaceutical composition, to a kit and to uses of the RNA containing compositions for the treatment or prophylaxis of tumor and/or cancer diseases

公开(公告)号：EP2839839B1

公开(公告)日：2018-01-17

申请号：EP14185916.5

申请日：2008-02-28

Applicant: Yeda Research And Development Company Limited

Inventor： Seger, Rony ,  Chuderland, Dana

IPC: C07K7/08 ,  C07K14/47 ,  C12N15/113 ,  A61K35/00

CPC classification number: C07K7/08 ,  A61K48/0041 ,  C07K14/47 ,  C07K16/18 ,  C07K16/2866 ,  C07K2319/09 ,  C12N15/113 ,  C12N15/87 ,  C12N2810/85

Abstract: The present invention relates to a peptide comprising an amino acid sequence at least 70 % homologous to a sequence as set forth by LDQLNHILGILGX 1 PX 2 QED; wherein X 1 and X 2 are non-phosphorylatable amino acids, the isolated peptide being capable of preventing ERK nuclear translocation.

公开(公告)号：EP3106177A4

公开(公告)日：2018-01-03

申请号：EP14882238

申请日：2014-02-12

Applicant: ACCURNA INC

Inventor： KATAOKA KAZUNORI ,  ITAKA KEIJI ,  ISHII TAKEHIKO ,  UCHIDA HIROKUNI ,  UCHIDA SATOSHI ,  BABA MIYUKI

IPC: A61K48/00 ,  A61K31/7088 ,  A61K31/7115 ,  A61K47/34 ,  A61P1/16 ,  A61P7/00 ,  A61P11/02 ,  C12N15/09

CPC classification number: A61K48/0041 ,  A61K9/0019 ,  A61K9/1075 ,  A61K31/7105 ,  A61K31/7115 ,  A61K38/1761 ,  A61K38/18 ,  A61K38/185 ,  A61K47/10 ,  A61K47/34 ,  C12N15/87

Abstract: [Problem to be Solved] The invention provides a composition and a pharmaceutical composition for delivering mRNA. [Solution] A polyion complex comprising a polycationic polymer and a messenger RNA (mRNA).

公开(公告)号：EP2996676A4

公开(公告)日：2017-03-29

申请号：EP14798171

申请日：2014-05-14

Applicant: UNIV UTAH RES FOUND

Inventor： KIM SUNG WAN ,  LEE YOUNG SOOK ,  LEE MINHYUNG

IPC: A61K47/59 ,  A61K9/14 ,  A61K31/795 ,  A61K47/69 ,  A61K48/00 ,  A61P9/00

CPC classification number: C08G75/14 ,  A61K31/795 ,  A61K47/59 ,  A61K47/6935 ,  A61K48/0041 ,  A61K48/005 ,  C08G69/42 ,  C08G73/0253 ,  C08G73/028

Abstract: phEPO/ABP polyplexes and methods for the use thereof are disclosed and described. In one embodiment, a phEPO/ABP polyplex may be administered to a subject in a therapeutically effective amount to treat or prevent a cardiac condition. Administration may 5 be made, in some aspects, by intramyocardial injection of a composition or solution containing the phEPO/ABP polyplex.