公开(公告)号：EP4355897A1

公开(公告)日：2024-04-24

申请号：EP22747808.8

申请日：2022-06-13

申请人： Trustees of Boston University ,  Northwestern University

发明人： CHENG, Ji-Xin ,  LI, Junjie ,  TAN, Yuying ,  MATEI, Daniela ,  ZHAO, Guangyuan

IPC分类号： C12Q1/54 ,  C12Q1/61 ,  G01N33/92

CPC分类号： G01N33/5011 ,  G01N21/65 ,  G01N2021/65620130101 ,  G01N2021/65520130101

公开(公告)号：EP4343311A2

公开(公告)日：2024-03-27

申请号：EP23212203.6

申请日：2016-09-22

申请人： Trustees of Boston University

发明人： UNLU, Selim ,  DAABOUL, George G. ,  CHIARI, Marcella

IPC分类号： G01N21/45

摘要： Provided herein are methods for capturing extracellular vesicles from a biological sample for quantification and/or characterization ( e.g., size and/or shape discrimination) using an SP-IRIS system. Also provided herein are methods of detecting a biomarker on captured extracellular vesicles or inside the captured vesicles ( e.g., intra-vesicular or intra-exosomal biomarkers).

公开(公告)号：EP4337791A1

公开(公告)日：2024-03-20

申请号：EP22808132.9

申请日：2022-05-09

申请人： Trustees of Boston University ,  Fraunhofer USA, Inc. ,  Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.

发明人： MCBETH, Christine ,  BORCHERS, Kirsten ,  WEBER, Achim ,  ZONTAR, Daniel

IPC分类号： C12Q1/686 ,  B82Y30/00

公开(公告)号：EP4313061A1

公开(公告)日：2024-02-07

申请号：EP21935395.0

申请日：2021-03-31

申请人： The Board of Trustees of the Leland Stanford Junior University ,  Trustees of Boston University

发明人： LIANG, Liang ,  SNYDER, Michael, P. ,  ALVIRA, Cristina M. ,  CORNFIELD, David N. ,  YING, Lihua ,  SNYDER, John K.

IPC分类号： A61K31/57 ,  C07J7/00 ,  A61P5/24 ,  A61P5/34

公开(公告)号：EP4185855A1

公开(公告)日：2023-05-31

申请号：EP22854122.3

申请日：2022-08-05

申请人： Trustees of Boston University

发明人： CHENG, Ji-Xin ,  LAN, Lu ,  YIN, Jiaze

IPC分类号： G01N21/17 ,  G01N21/63 ,  H04N5/33 ,  G06T11/00 ,  G01N21/3563

公开(公告)号：EP3947432A1

公开(公告)日：2022-02-09

申请号：EP20783932.5

申请日：2020-03-27

申请人： Trustees of Boston University

发明人： NGO, John T. ,  WONG, Wilson ,  WONG, Meng Lai Nicole ,  LI, Huishan ,  TAGUE, Elliot P.

IPC分类号： C07K14/705 ,  C07K14/725 ,  C07K16/28

公开(公告)号：EP3878952A1

公开(公告)日：2021-09-15

申请号：EP21162822.7

申请日：2014-07-01

申请人： Massachusetts Institute Of Technology ,  Trustees of Boston University

发明人： Lu, Timothy Kuan-Ta ,  Citorik, Robert James ,  Collins, James ,  Krom, Russell-John

IPC分类号： C12N7/01 ,  C12N15/70 ,  C12N15/74 ,  A61P1/00

摘要： Various aspects and embodiments of the present disclosure are directed to methods and compositions for functionalizing endogenous bacteria in vivo. The methods include delivering to endogenous bacterial cells a recombinant bacteriophage or phagemid that is engineered to contain at least one genetic circuit.

公开(公告)号：EP3770278A1

公开(公告)日：2021-01-27

申请号：EP20192274.7

申请日：2006-04-14

申请人： The Trustees of Boston University

发明人： BRODY, Jerome S ,  SPIRA, Avrum ,  BEANE-EBEL, Jennifer ,  LENBURG, Marc E

IPC分类号： C12Q1/6886

摘要： The present invention provides methods for diagnosis and prognosis of lung cancer using expression analysis of one or more groups of genes, and a combination of expression analysis with bronchoscopy. The methods of the invention provide far superior detection accuracy for lung cancer when compared to any other currently available method for lung cancer diagnostic or prognosis. The invention also provides methods of diagnosis and prognosis of other lung diseases, particularly in individuals who are exposed to air pollutants, such as cigarette or cigar smoke, smog, asbestos and the like air contaminants or pollutants.

公开(公告)号：EP3077551B1

公开(公告)日：2020-04-01

申请号：EP14868654.6

申请日：2014-12-05

申请人： President and Fellows of Harvard College ,  Trustees of Boston University

发明人： PARDEE, Keith ,  COLLINS, James J.

IPC分类号： C12Q1/6806

公开(公告)号：EP3571212A2

公开(公告)日：2019-11-27

申请号：EP18742301.7

申请日：2018-01-23

申请人： Trustees of Boston University

发明人： PAVEL, Ana Brandusa ,  CAMPBELL, Joshua David ,  LENBURG, Marc Elliott ,  SPIRA, AVRUM

IPC分类号： C07H21/04 ,  C12Q1/68 ,  C40B30/04