公开(公告)号：EP0844884A2

公开(公告)日：1998-06-03

申请号：EP95940801.0

申请日：1995-11-30

申请人： CHWALISZ, Krzysztof ,  GARFIELD, Robert

发明人： CHWALISZ, Krzysztof ,  GARFIELD, Robert

IPC分类号： A61K31 ,  A61K38 ,  A61K45

CPC分类号： A61K45/06 ,  A61K31/00 ,  A61K31/223 ,  A61K31/42 ,  A61K31/565 ,  A61K31/57 ,  A61K31/60 ,  A61K38/12 ,  Y10S514/899 ,  A61K2300/00

摘要： A pharmaceutical composition for and methods of treatment of menstrual disorders, e.g., dysmenorrhea, in a non-pregnant female, preterm labor, preeclampsia and/or fetal growth retardation in a pregnant female mammal, treatment of atherosclerotic vascular disease and hypertension in males as well as females, and for hormone replacement therapy in peri- and post-menopausal females, comprising administering effective amounts of an endothelin antagonist and/or an endothelin synthase inhibitor or both, in combination with (a) a progestin, and/or and estrogen, and/or (b) a cyclooxygenase inhibitor, and/or (c) a nitric oxide donor and/or nitric substrate, to prevent and/or ameliorate said conditions, are disclosed. In the method aspects, the endothelin antagonist and/or endothelin synthase inhibitor can be administered alone for treatment of menstrual disorders, e.g., dysmenorrhea, in a non-pregnant female, preterm labor, preeclampsia and/or fetal growth retardation in a pregnant female mammal. Further, methods for screening compounds for such treatments are disclosed.

公开(公告)号：EP0711126A1

公开(公告)日：1996-05-15

申请号：EP94905511.0

申请日：1993-12-22

申请人： GARFIELD, Robert ,  CHWALISZ, Krzysztof ,  BUKOWSKI, Radoslaw

发明人： GARFIELD, Robert ,  CHWALISZ, Krzysztof ,  BUKOWSKI, Radoslaw

IPC分类号： A61B5 ,  A61B10 ,  A61N1

CPC分类号： A61B5/411 ,  A61B5/04882 ,  A61B5/0492 ,  A61N1/05 ,  A61N1/36007

摘要： Monitoring the electrical activity of the uterus is used as a predictor of labor. In accordance with a first embodiment, the existence of gap junctions between cells is detected by stimulating the cells with electrical pulses having selective parameters and then detecting propagated signals emitted by the cells. In accordance with this embodiment, a needle (20) is provided having stimulation electrodes (44) thereon from which the stimulating pulses emanate and an array (40) of recording electrodes for detecting the pulses. In an alternative approach, an array of piezoelectric electrodes (70) is distributed within the array of recording electrodes (40). The signals detected by the recording electrodes (40) and piezoelectric electrodes (70) are monitored by a recording device (24) and stored within a computer (104).