公开(公告)号：EP2758423A2

公开(公告)日：2014-07-30

申请号：EP12791277.2

申请日：2012-09-18

申请人： Istituto Superiore di Sanità ,  CRA Consiglio per la Ricerca e la sperimentazione in Agricoltura

发明人： SILANO, Marco ,  CATTIVELLI, Luigi ,  DE VITA, Pasquale ,  MAIURI, Luigi ,  FICCO, Donatella Bianca Maria

IPC分类号： C07K14/415 ,  A61K38/16 ,  A61P1/00

摘要： The present invention concerns peptides having protective effect towards inflammatory activity of a-gliadin 31-43 peptide in celiac disease and therefore can be used for preventive and therapeutic purpose by administration thereof to subjects at high risk to develop celiac disease and/or celiac subjects just before a gluten containing meal to be ingested.

公开(公告)号：EP2758423B1

公开(公告)日：2020-08-19

申请号：EP12791277.2

申请日：2012-09-18

申请人： Istituto Superiore di Sanità ,  CRA-Consiglio per la Ricerca e la Sperimentazione in Agricoltura

发明人： SILANO, Marco ,  CATTIVELLI, Luigi ,  DE VITA, Pasquale ,  MAIURI, Luigi ,  FICCO, Donatella Bianca Maria

IPC分类号： C07K14/415 ,  A61K38/16 ,  A61P1/00

公开(公告)号：EP2339008A1

公开(公告)日：2011-06-29

申请号：EP09180669.5

申请日：2009-12-23

申请人： Universita' Degli Studi Di Milano ,  CRA Consiglio per la Ricerca e la sperimentazione in Agricoltura

发明人： Colombo, Lucia ,  Kater, Martin ,  Kooiker, Maarten Christiaan ,  Lindner, Matias ,  Rotino, Giuseppe Leonardo ,  Toppino, Laura

IPC分类号： C12N15/82 ,  A01H5/00

CPC分类号： C12N15/8289

摘要： The present invention concerns the inducting of recoverable male sterility in plants through the introduction into the plant genome of a genic construct comprising a blocking construct, which blocks the activity of a gene involved into the pollen formation and a rescue construct, which is able to restore fertility under suitable conditions.

摘要翻译： 本发明涉及通过引入到植物基因组中诱导植物中的可恢复的雄性不育，所述基因构建体包含阻断构建体，其阻断参与花粉形成的基因的活性和能够还原的拯救构建体 适宜条件下的生育力。