公开(公告)号：EP4230729A1

公开(公告)日：2023-08-23

申请号：EP21880541.4

申请日：2021-10-14

申请人： Sungkwang Medical Foundation ,  Cha Biolab Co., Ltd.

发明人： BAEK, Young Seok ,  AN, Hee Jung ,  KANG, Myung Seo ,  MOON, Yong Wha ,  PARK, Kyung Soon ,  LEE, In Jee ,  HWANG, So Hyun

IPC分类号： C12N5/0783 ,  C12N5/00 ,  A61K35/17 ,  A61K48/00 ,  A61P35/00

摘要： Provided are a method of culturing high-purity, highly active natural killer cells of which expression of anti-cancer-related gene is regulated, and use thereof for anticancer immunotherapy. In the natural killer cells according to one aspect, the expression of anticancer related genes is significantly increased or decreased before and after culture. The natural killer cells have the unique characteristics thereof, and remarkably high activity and proliferation fold. Therefore, the natural killer cells can be used for effective anticancer immunotherapy.

公开(公告)号：EP3922715A1

公开(公告)日：2021-12-15

申请号：EP20791036.5

申请日：2020-04-17

申请人： CHA Biotech Co., Ltd. ,  Cha Biolab Co., Ltd.

发明人： BAEK, Young Seok ,  LEE, In Jee

IPC分类号： C12N5/0783 ,  A61K35/17 ,  A61P35/00

摘要： Provided are a natural killer cell exhibiting increased anticancer activity and immunotherapeutic use thereof. According to the natural killer cell according to an aspect, a relative mean fluorescence intensity (MFI) of a specific receptor significant for cancers including glioblastoma is increased, and thus effective anticancer immunotherapy is possible.