公开(公告)号：EP2446928A1

公开(公告)日：2012-05-02

申请号：EP10815423.8

申请日：2010-09-09

申请人： Tokai University Educational System ,  Comet Corporation

发明人： ITOH, Johbu

IPC分类号： A61N5/06

CPC分类号： A61N5/0601 ,  A61B18/18 ,  A61B2018/1807 ,  A61N5/0613 ,  A61N2005/0654 ,  A61N2005/0661

摘要： It is an object of the present invention to provide a method and an apparatus capable of selectively damaging and killing tumor cells. In one aspect of the present invention, there is provided a method for selectively damaging and killing tumor cells comprising a step of irradiating tumor cells with a pulse light having continuous emission spectra ranging at least from 230 to 270 nm (UV pulse flash), outside a living body of a human or a living body of a non-human animal or in a living body of a non-human animal. The UV pulse flash, preferably, has an accumulated irradiation amount per unit area that is achieved at a distance of 8 cm from a light source having an integrated output of, for example, 90, 180-7100 or 14200 J. In other words, the UV pulse flash, preferably, has an accumulated irradiation amount per unit area of, for example, 6, 12-480 or 960 J/cm 2 in terms of an energy originated from a wavelength of UVC. The step of irradiating with the UV pulse flash is preferably carried out, for example, within 1 minute. The UV pulse flash is preferably emitted from a xenon flash lamp. As another aspect of the present invention, there is provided an apparatus for treating tumor tissues comprising a light source of the UV pulse flash.

摘要翻译： 它是本发明的一个目的是提供一种方法和一种能够选择性地破坏和杀死肿瘤细胞的装置。 在本发明的一个方面，提供了一种方法，用于选择性破坏和杀死肿瘤细胞，其包括照射肿瘤细胞与具有连续发射光谱范围的至少230至270纳米（UV脉冲闪光）的脉冲光的步骤中，外 人类的活体或非人类动物的或在非人类动物的生物体内的生物体。 的UV脉冲闪光灯，优选地，具有对没有由具有在积分输出，例如，90，180-7100或14200 J.换句话说光源取得在8厘米的距离每单位面积的累积照射量， 紫外脉冲闪光灯，优选地，具有每单位面积累积照射量，例如，6，12至480或960焦耳/ cm 2的在能量方面源于UVC的波长。 用UV脉冲闪光照射的步骤优选进行，例如，分钟内的第一 的UV脉冲闪光灯优选由氙闪光灯发射的。 作为本发明的另一个方面，提供了到用于治疗肿瘤组织，包括紫外脉冲闪光的光源。