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公开(公告)号：EP2357478A3
公开(公告)日：2011-11-16
申请号：EP10186268.8
申请日：2001-11-30
发明人： Tazi-Ahnini, Rachid , Duff, Gordon , Cork, Michael , Ward, Simon , Bavik, Claes
IPC分类号： G01N33/68 , G01N33/564
CPC分类号： G01N33/564 , G01N33/6881 , G01N2500/00 , G01N2800/20 , G01N2800/205
摘要： We disclose a method of diagnosis of a disease, or susceptibility to a disease associated with abnormal cell-cell adhesion between epithelial cells, the method comprising detection of a mutation in a nucleic acid encoding an adhesion protein, a protease, or a protease inhibitor of an individual.
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公开(公告)号：EP1356298B1
公开(公告)日：2011-05-18
申请号：EP01998835.1
申请日：2001-11-30
发明人： TAZI-AHNINI, Rachid , BAVIK,Claes , WARD, Simon , DUFF,Gordon , CORK, Michael
CPC分类号： G01N33/564 , G01N33/6881 , G01N2500/00 , G01N2800/20 , G01N2800/205
摘要： We disclose a method of diagnosis of a disease, or susceptibility to a disease associated with abnormal cell-cell adhesion between epithelial cells, the method comprising detection of a mutation in a nucleic acid encoding an adhesion protein, a protease, or a protease inhibitor of an individual.
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公开(公告)号：EP2357478A2
公开(公告)日：2011-08-17
申请号：EP10186268.8
申请日：2001-11-30
发明人： Tazi-Ahnini, Rachid , Duff, Gordon , Cork, Michael , Ward, Simon , Bavik, Claes
IPC分类号： G01N33/68 , G01N33/564
CPC分类号： G01N33/564 , G01N33/6881 , G01N2500/00 , G01N2800/20 , G01N2800/205
摘要： We disclose a method of diagnosis of a disease, or susceptibility to a disease associated with abnormal cell-cell adhesion between epithelial cells, the method comprising detection of a mutation in a nucleic acid encoding an adhesion protein, a protease, or a protease inhibitor of an individual.
摘要翻译： 我们公开了一种疾病的诊断方法或对与上皮细胞之间异常细胞 - 细胞粘附相关的疾病的易感性的方法，所述方法包括检测编码粘附蛋白的核酸，蛋白酶或蛋白酶抑制剂中的突变 个人。
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公开(公告)号：EP2331086A2
公开(公告)日：2011-06-15
申请号：EP08842974.1
申请日：2008-10-22
发明人： SCHMIDTS, Thomas M. , RUNKEL, Frank
IPC分类号： A61K9/70
CPC分类号： A61K9/0017 , A61K31/506 , A61K31/57 , A61K47/10 , A61K47/12
摘要： The present invention relates to a pharmaceutical formulation comprising a pharmaceutically activeagent; water; a polyethylene glycol or a poloxamer; and a polyethylene glycol mono- or di-ether. Preferably the pharmaceutically active agent is an anti-fungal or anti-mycotic agent. Preferably the pharmaceutically active agent is lipophilic and/or keratinophilic. The present invention also relates to the use of the formulation in treating diseases, disorders or pathological conditions of the nail or skin, such as onychomycosis, dermatomycosis and other mycoses. The present invention also relates to a method of administering a pharmaceutically active agent to a subject by applying the formulation comprising the pharmaceutically active agent to a nail or skin of the subject. The present invention further relates to a method of preparing the formulation.
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