公开(公告)号：EP3105345A1

公开(公告)日：2016-12-21

申请号：EP15705264.8

申请日：2015-02-11

申请人： Cray Innovation AB

发明人： FORSBERG, Lars ,  DUMANSKI, Jan

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q2600/118 ,  C12Q2600/156

摘要： Male subjects having an increased risk of developing Alzheimer's disease are identified by determining a fraction of cells that have lost chromosome Y in a biological sample obtained from the male subject. The fraction is compared to a predefined threshold and the male subject is predicted to have an increased risk of developing Alzheimer's disease based on the comparison between the fraction and the predefined threshold.

摘要翻译： 通过测定从男性受试者获得的生物样品中已经失去染色体Y的细胞的分数来鉴定具有发展阿尔茨海默氏病风险增加的男性受试者。 将该部分与预定义的阈值进行比较，并且基于比例和预定阈值，预测男性受试者具有发展阿尔茨海默氏病的风险增加。

公开(公告)号：EP3983565A1

公开(公告)日：2022-04-20

申请号：EP20731494.9

申请日：2020-06-12

申请人： Cray Innovation AB

发明人： FORSBERG, Lars ,  DUMANSKI, Jan

IPC分类号： C12Q1/6886 ,  C12Q1/6879

公开(公告)号：EP3055425B1

公开(公告)日：2018-03-14

申请号：EP14789193.1

申请日：2014-10-07

申请人： Cray Innovation AB

发明人： FORSBERG, Lars ,  DUMANSKI, Jan

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q1/6879 ,  C12Q2600/118 ,  C12Q2600/156

摘要： Male subjects having an increased risk of developing cancer are identified by determining a fraction of cells that have lost chromosome Y in a biological sample obtained from the male subject. The fraction is compared to a predefined threshold and the male subject is predicted to have an increased risk of developing cancer based on the comparison between the fraction and the predefined threshold.

公开(公告)号：EP3105345B1

公开(公告)日：2019-04-10

申请号：EP15705264.8

申请日：2015-02-11

申请人： Cray Innovation AB

发明人： FORSBERG, Lars ,  DUMANSKI, Jan

IPC分类号： C12Q1/6883

公开(公告)号：EP3055425A1

公开(公告)日：2016-08-17

申请号：EP14789193.1

申请日：2014-10-07

申请人： Cray Innovation AB

发明人： FORSBERG, Lars ,  DUMANSKI, Jan

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q1/6879 ,  C12Q2600/118 ,  C12Q2600/156

摘要： Male subjects having an increased risk of developing cancer are identified by determining a fraction of cells that have lost chromosome Y in a biological sample obtained from the male subject. The fraction is compared to a predefined threshold and the male subject is predicted to have an increased risk of developing cancer based on the comparison between the fraction and the predefined threshold.

摘要翻译： 通过测定从男性受试者获得的生物样品中已经失去染色体Y的细胞的一部分来鉴定具有发展癌症风险增加的男性受试者。 将该分数与预定义的阈值进行比较，并且基于分数与预定阈值之间的比较，预测男性受试者具有发展癌症的风险增加。