公开(公告)号：EP4335437A1

公开(公告)日：2024-03-13

申请号：EP22194419.2

申请日：2022-09-07

申请人： Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus ,  Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts

发明人： GRETEN, Florian ,  DENK, Dominic Pascal ,  PETROCELLI, Valentina ,  BUCHHOLZ, Christian ,  BRAUN, Angela

IPC分类号： A61K31/37 ,  A61P37/02 ,  C12N5/00 ,  C12N5/0783

摘要： The invention is based on the use of Urolithin A for improving mitochondrial health in immune cells such as T-cells. The invention provides new strategies to enhance immune cell based therapies, such as adoptive T-cell therapy. The compounds and compositions of the invention are preferably useful for therapies that involve in vitro T cell modification and expansion, such as modification of T cells with a chimeric antigen receptor (CAR) for treating an antigen associated disorder, such as cancer.

公开(公告)号：EP4320244A1

公开(公告)日：2024-02-14

申请号：EP22721342.8

申请日：2022-04-07

申请人： Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts

发明人： BRAUN, Angela ,  FRANK, Annika ,  BUCHHOLZ, Christian

IPC分类号： C12N15/87 ,  A61K31/506 ,  C12N15/867