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公开(公告)号：EP4377695A1
公开(公告)日：2024-06-05
申请号：EP22760676.1
申请日：2022-07-29
发明人： FAVA, Eugenio , SCHNEIDER, Anja , ROTH, Wera , DHOLE, Pranjal , BLERSCH, Josephine , DENNER, Philip
CPC分类号： G01N33/6896 , G01N33/5047 , G01N2500/0020130101
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公开(公告)号：EP3487886A2
公开(公告)日：2019-05-29
申请号：EP17783725.9
申请日：2017-07-24
申请人： Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. (DZNE) , Ludwig-Maximilians-Universität München
IPC分类号： C07K16/28
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公开(公告)号：EP2878677A1
公开(公告)日：2015-06-03
申请号：EP13194865.5
申请日：2013-11-28
申请人： Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. (DZNE) , Technische Universität München
发明人： Groll, Michael , Richter, Klaus , Haslbeck, Veronika , Striggow, Frank , Martin, Helmuth , Schmidt, Werner , Weiwad, Matthias , Fischer, Gunter
IPC分类号： C12Q1/42
CPC分类号： C12Q1/42 , A61K31/381 , A61K31/4245 , A61K31/4365 , A61K31/519 , A61K31/53 , G01N2500/04
摘要： The present invention relates to compounds that show a positive result in a phosphatase activation assay with protein phosphatase 5 according to the invention, to compounds that bind in an in vitro binding assay to a certain region of the amino acid sequence of protein phosphatase 5, as well as to compounds that show a positive result in a phosphatase activation assay with protein phosphatase 5 according to the invention and bind in an in vitro binding assay to a certain region of the amino acid sequence of protein phosphatase 5. The present invention also relates to pharmaceutical compositions comprising one or more of such compounds, to methods of using such a compound, and to methods of screening for compounds that activate protein phosphatase 5.
摘要翻译： 本发明涉及在根据本发明的蛋白磷酸酶5的磷酸酶活化测定中显示阳性结果的化合物与在蛋白质磷酸酶5的氨基酸序列的某个区域的体外结合测定中结合的化合物，如 以及在根据本发明的蛋白磷酸酶5的磷酸酶活化测定中显示阳性结果的化合物，并且在体外结合测定中结合蛋白磷酸酶5的氨基酸序列的某一区域。本发明还涉及 包含一种或多种这些化合物的药物组合物，使用这种化合物的方法，以及筛选活化蛋白磷酸酶5的化合物的方法。
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4.发明公开
公开(公告)号：EP4374869A1
公开(公告)日：2024-05-29
申请号：EP22209887.3
申请日：2022-11-28
发明人： ZWECKSTETTER, Markus , RAMIREZ, Lisa-Marie , IBÁÑEZ DE OPAKUA LÓPEZ DE ABETXUKO, Alain , VORBERG, Ina , HEBESTREIT, Alina , MADHUBABU, Gajula Balija
IPC分类号： A61K38/14 , A61K31/7048 , A61P25/28
CPC分类号： A61K38/14 , A61P25/28 , A61K31/7048
摘要： The invention relates to a cyclic lipopeptide antibiotic compound, or derivative and/or salt thereof, for use in the treatment and/or prevention of a medical condition associated with protein aggregation, preferably amyloidosis. The invention further relates to the compound comprising 5 to 20 amino acids, 3 or more non-proteinogenic amino acids, 5 or more amino acids with a side chain comprising an aromatic ring, one to four cyclic structures, and at least one amino acid is substituted with a hydrophobic moiety. In another preferred embodiment the treatment comprises binding of the compound to a protein and inhibiting protein aggregate formation and/or fibril elongation and/or inhibition of association between monomers of aggregating proteins, inhibition of protein oligomerization, inhibition of protein condensation, inhibition of secondary nucleation processes in fibril formation, such as disrupting replication of aggregate formation on the surface of an existing fibril, and/or inhibition of fibril elongation by capping fibril ends.
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公开(公告)号：EP3525788A1
公开(公告)日：2019-08-21
申请号：EP17787904.6
申请日：2017-10-10
申请人： Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. (DZNE) , Klinikum rechts der Isar der Technischen Universität München
IPC分类号： A61K31/4375 , A61K31/519 , A61K31/713 , C12N15/113 , A61P25/28 , A61P25/16
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6.发明公开
公开(公告)号：EP3271377A1
公开(公告)日：2018-01-24
申请号：EP16709392.1
申请日：2016-03-10
申请人： Ludwig-Maximilians-Universität München , Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. (DZNE)
发明人： WILLEM, Michael , HAASS, Christian
IPC分类号： C07K14/435
CPC分类号： C07K14/4711 , A61K38/00 , G01N33/6896 , G01N2333/4709 , G01N2800/2821
摘要： The present invention relates to a peptide or collection of peptides derived from amyloid precursor protein (APP). The present invention also relates to uses of such peptide or collection of peptides, in particular as a diagnostic marker and/or as a drug target.
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7.发明公开
公开(公告)号：EP4267602A1
公开(公告)日：2023-11-01
申请号：EP21830701.5
申请日：2021-12-22
IPC分类号： C07K14/725 , C07K14/705
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8.发明公开
公开(公告)号：EP4023768A1
公开(公告)日：2022-07-06
申请号：EP20217509.7
申请日：2020-12-29
IPC分类号： C12Q1/6883
摘要： The invention is based on the detection of microRNA (miR) in biological samples derived from subjects for assessing a risk that the subject develops a neurological and / or neuropsychological condition. The invention in particular detects the presence or absence and the amount of microRNA-181a-5p, microRNA146a-5p and/or microRNA148a-3p in such samples, which are shown by the invention to be associated with the neurological and / or neuropsychological condition. In addition, the invention provides a therapeutic application for the treatment of the neurological and / or neuropsychological condition by modulating the expression/function of these miR.
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公开(公告)号：EP3999850A1
公开(公告)日：2022-05-25
申请号：EP20734787.3
申请日：2020-07-02
IPC分类号： G01N33/564 , G01N33/94 , C07K14/705
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10.发明公开
公开(公告)号：EP3829717A2
公开(公告)日：2021-06-09
申请号：EP19753269.0
申请日：2019-07-31
申请人： Medizinische Hochschule Hannover (MHH) , Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. (DZNE)
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