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    PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF FUNCTIONAL DYSPEPSIA AND/OR IRRITABLE BOWEL SYNDROME AND NEW USE OF SUBSTANCES THEREIN
    1.
    发明公开
    PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF FUNCTIONAL DYSPEPSIA AND/OR IRRITABLE BOWEL SYNDROME AND NEW USE OF SUBSTANCES THEREIN 有权
    药物组合物，功能性消化不良和/或肠易激综合症的治疗和新物质在这个组合物中使用

    公开(公告)号：EP1094834A1

    公开(公告)日：2001-05-02

    申请号：EP99930089.0

    申请日：1999-06-08

    申请人： Hellström, Per ,  EFENDIC, Suad

    发明人： Hellström, Per ,  EFENDIC, Suad

    IPC分类号： A61K38/26 ,  A61K38/31

    CPC分类号： A61K38/26 ,  A61K38/31 ,  A61K2300/00

    摘要： The invention relates to the new use of gastrointestinal peptide hormones selected from the class consisting of glucagon-like peptide-1 (GLP-1) and derivatives thereof having anti-secretory effects and smooth muscle relaxatory properties in the gastrointestinal tract for the manufacture of a pharmaceutical composition for the treatment of functional dyspepsia and/or irritable bowel syndrome. The invention also relates to a pharmaceutical composition comprising a combination of at least one member selected from said class consisting of GLP-1 and derivatives thereof with one or more other gastrointestinal peptide hormone(s) or derivative(s) thereof together with pharmacologically acceptable additives and to a method of treating functional dyspepsia or irritable bowel syndrome or both by administering an effective amount of at least one member of said class consisting of GLP-1 and derivatives thereof having effects and properties as mentioned above.

    METHOD FOR DIAGNOSIS AND TREATMENT OF DISORDERS OF CARBOHYDRATE METABOLISM
    4.
    发明公开
    METHOD FOR DIAGNOSIS AND TREATMENT OF DISORDERS OF CARBOHYDRATE METABOLISM 审中-公开
    方法进行诊断和治疗扰动CARBOHYDRATMETABOLISMUS的

    公开(公告)号：EP1053356A2

    公开(公告)日：2000-11-22

    申请号：EP99906659.0

    申请日：1999-02-11

    申请人： EFENDIC, Suad

    发明人： EFENDIC, Suad

    IPC分类号： C12Q1/68 ,  A01K67/027 ,  C12N9/88

    CPC分类号： C12Q1/6883 ,  A01K2217/05 ,  A01K2217/075 ,  A01K2267/0306 ,  A01K2267/0362 ,  A01K2267/0393 ,  C12N9/88 ,  C12N15/8509 ,  C12Q2600/156 ,  C12Q2600/158

    摘要： The present invention relates to a method of detecting a disorder in carbohydrate metabolism, such as type II diabetes (NIDDM), by detecting a promoter of an adenylate cyclase III gene, the promoter having enhanced activity. The present invention also relates to a promoter from an adenylate cyclase III gene having enhanced activity, and isolated DNA molecules containing this promoter. The promoter having enhanced activity can be part of a transgenic animal. In another embodiment, the invention relates to a method of treating a patient having a disorder in carbohydrate metabolism, such as type II diabetes (NIDDM), and a method of enhancing or restoring a patient's response to insulin. Each of these methods includes administering to the patient a down regulator, an antagonist, or an inhibitor of expression of the adenylate cyclase III gene, or of the activity of one of its gene products.