公开(公告)号：EP3044196A4

公开(公告)日：2017-05-24

申请号：EP14844537

申请日：2014-09-10

申请人： EQUIP LLC

发明人： DAVIS PAUL D

IPC分类号： C07C43/11 ,  C09B23/12

CPC分类号： C09B68/444 ,  C07D209/58 ,  C07D403/12 ,  C09B69/00 ,  G01N33/533 ,  G01N33/582

摘要： Disclosed are discrete PEGylated dyes, that is, dyes, generally ones that are fluorescent, but could also include chemi-luminescent or electrochemiluminescent and related dye or dye precursors, that have discrete PEG constructs chemically attached in various configurations on the dye, and in the entire range of constructs, discrete PEG compounds (polyethylene glycol oligomers that are made synthetically according to methods disclosed in U.S. Pat. No. 7,888,536 and US Pub. No. 2013/0052130). The dyes are modified in a range of ways to control or optimize the properties of water solubility, non-specific binding (in vitro), biodistribution (in vivo), cell internalization (non-cell or cell based assays in vitro, and in vivo diagnostics and therapy), as well as aggregation.

摘要翻译： 公开了离散PEG化染料，即染料，通常是荧光染料，但也可包括化学发光或电化学发光和相关染料或染料前体，其具有在染料上以各种配置化学连接的离散PEG构建体，以及 整个范围的构建体，分立PEG化合物（根据美国专利号7,888,536和美国公布号2013/0052130中公开的方法合成制备的聚乙二醇低聚物）。 染料以一系列方式进行修饰，以控制或优化水溶性，非特异性结合（体外），生物分布（体内），细胞内化（体外非细胞或基于细胞的测定和体内 诊断和治疗）以及聚集。

公开(公告)号：EP3044196A1

公开(公告)日：2016-07-20

申请号：EP14844537.2

申请日：2014-09-10

申请人： Equip, LLC

发明人： DAVIS, Paul, D.

IPC分类号： C07C43/11 ,  C09B23/12

CPC分类号： C09B68/444 ,  C07D209/58 ,  C07D403/12 ,  C09B69/00 ,  G01N33/533 ,  G01N33/582

摘要： Disclosed are discrete PEGylated dyes, that is, dyes, generally ones that are fluorescent, but could also include chemi-luminescent or electrochemiluminescent and related dye or dye precursors, that have discrete PEG constructs chemically attached in various configurations on the dye, and in the entire range of constructs, discrete PEG compounds (polyethylene glycol oligomers that are made synthetically according to methods disclosed in U.S. Patent No. 7,888,536 and US Pub. No. 2013/0052130). The dyes are modified in a range of ways to control or optimize the properties of water solubility, non-specific binding (in vitro), biodistribution (
in vivo ), cell internalization (non-cell or cell based assays in vitro, and in vivo diagnostics and therapy), as well as aggregation.

公开(公告)号：EP4284437A1

公开(公告)日：2023-12-06

申请号：EP22746801.4

申请日：2022-01-31

申请人： Equip, LLC

发明人： GIESE, Matthew ,  DAVIS, Paul

IPC分类号： A61K47/50 ,  C07C27/16 ,  C07D209/48