公开(公告)号：EP1578711A4

公开(公告)日：2006-09-27

申请号：EP03812814

申请日：2003-12-04

申请人： GEMIN X BIOTECHNOLOGIES INC ,  GALILEO PHARMACEUTICALS INC

发明人： BEAUPARLANT PIERRE ,  ATTARDO GIORGIO ,  ZHANG ZHIYING ,  STAFFORD ANGELA M ,  UBILLAS ROSA ,  MCALPINE JAMES B ,  TRIPATHY SASMITA ,  LAVALLEE JEAN-FRANCOIS

IPC分类号： A61P35/00 ,  C07C45/29 ,  C07C49/755 ,  C07C69/00 ,  C07C43/162 ,  A61K31/085 ,  A61K31/121 ,  A61K31/502 ,  A61K31/517 ,  A61K31/55 ,  C07C43/164 ,  C07C49/115 ,  C07C49/12 ,  C07C49/225

CPC分类号： C07C69/757 ,  C07C45/292 ,  C07C49/755 ,  C07C2603/26

公开(公告)号：EP1255753B1

公开(公告)日：2004-06-23

申请号：EP01902193.0

申请日：2001-01-24

申请人： Gemin X Biotechnologies Inc.

发明人： MURTHY, Madiraju, S., R. ,  STEENAART, Nancy, A., E. ,  JOHNSON, Roy, A. ,  SHORE, Gordon, C.

IPC分类号： C07D403/14 ,  A61K31/40 ,  A61P31/00 ,  A61P35/00

CPC分类号： C07D403/14 ,  C07D207/44

摘要： The present invention relates to novel Pyrrole-Type compounds, compositions comprising Pyrrole-Type compounds, and methods useful for treating or preventing cancer or a neoplastic disorder comprising administering a composition comprising a Pyrrole-Type compound. The compounds, compositions, and methods of the invention are also useful for inhibiting the growth of a cancer cell or neoplastic cell. The present invention also relates to novel Pyrrole-Type compounds, compositions, and methods useful for treating or preventing a viral infection. The compounds, compositions, and methods of the invention are also useful for inhibiting the replication and/or infectivity of a virus.

公开(公告)号：EP1578711A2

公开(公告)日：2005-09-28

申请号：EP03812814.6

申请日：2003-12-04

申请人： Gemin X Biotechnologies Inc. ,  Galileo Pharmaceuticals, Inc.

发明人： BEAUPARLANT, Pierre ,  ATTARDO, Giorgio ,  ZHANG, Zhiying ,  STAFFORD, Angela, M. ,  UBILLAS, Rosa ,  MCALPINE, James, B. ,  TRIPATHY, Sasmita ,  LAVALLEE, Jean-François

IPC分类号： C07C43/162 ,  C07C43/164 ,  C07C49/115 ,  C07C49/12 ,  C07C49/225 ,  A61K31/085 ,  A61K31/121 ,  A61K31/517 ,  A61K31/502 ,  A61K31/55 ,  A61P35/00

CPC分类号： C07C69/757 ,  C07C45/292 ,  C07C49/755 ,  C07C2603/26

摘要： The present invention relates to Diterpenoid Compounds, compositions comprising an effective amount of a Diterpenoid Compound, and methods useful for treating or preventing cancer or a neoplastic disorder comprising administering an effective amount of a Diterpenoid Compound. The compounds, compositions, and methods of the invention are also useful for inhibiting the growth of a cancer cell or neoplastic cell, or for inducing apoptosis in a cancer or neoplastic cell. The compounds, compositions, and methods of the invention are further useful for treating or preventing a fungal infection. The compounds, compositions, and methods of the invention are also useful for inhibiting the growth of a fungus.

摘要翻译： 本发明涉及二萜化合物，包含有效量的二萜化合物的组合物和可用于治疗或预防癌症或肿瘤性疾病的方法，包括给予有效量的二萜化合物。 本发明的化合物，组合物和方法也可用于抑制癌细胞或肿瘤细胞的生长，或诱导癌或肿瘤细胞凋亡。 本发明的化合物，组合物和方法进一步用于治疗或预防真菌感染。 本发明的化合物，组合物和方法也可用于抑制真菌的生长。

公开(公告)号：EP1427722B1

公开(公告)日：2007-11-14

申请号：EP02753971.7

申请日：2002-07-18

申请人： Gemin X Biotechnologies Inc.

发明人： SHORE, Gordon, C. ,  MURTHY, Madiraju, S., R. ,  JOHNSON, Roy, A. ,  ATTARDO, Giorgio

IPC分类号： C07D403/14 ,  C07D409/14 ,  C07D207/44 ,  A61K31/4025 ,  A61P35/02

CPC分类号： C07D403/14 ,  C07D207/36 ,  C07D207/44 ,  C07D403/10 ,  C07D405/14 ,  C07D409/14

摘要： The present invention relates to novel Pyrrole-Type compounds (I), compositions comprising Pyrrole-Type compounds, and methods useful for treating or preventing cancer or a neoplastic disorder comprising administering a Pyrrole-Type compound. The compounds, compositions, and methods of the invention are also useful for inhibiting the growth of a cancer cell or neoplastic cell. The present invention also relates to novel Pyrrole-Type compounds, compositions, and methods useful for treating or preventing a viral infection. The compounds, compositions, and methods of the invention are also useful for inhibiting the replication and/or infectivity of a virus. The present invention also relates to novel Pyrrole-Type compounds, compositions, and methods useful for causing immunosuppression. The present invention also relates to novel Pyrrole-Type compounds, compositions, and methods useful for treating or preventing an autoimmune disease.

公开(公告)号：EP1836165A1

公开(公告)日：2007-09-26

申请号：EP05823816.3

申请日：2005-12-22

申请人： Gemin X Biotechnologies Inc.

发明人： ATTARDO, Giorgio ,  TRIPARTHY, Sasmita ,  RIOUX, Elise ,  GONZALEZ, Gerson

IPC分类号： C07D207/44 ,  C07D409/14 ,  C07D401/14 ,  A61P35/00 ,  A61K31/4439 ,  A61K31/4025 ,  A61P31/12 ,  A61K31/5377 ,  A61K31/506 ,  A61K31/4709

CPC分类号： C07D207/44 ,  A61K31/4025 ,  A61K31/4439 ,  A61K31/4709 ,  A61K31/506 ,  A61K31/5377 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14

摘要： The present invention relates to novel Dipyrrole Compounds, compositions comprising a Dipyrrole Compound, and methods useful for treating or preventing cancer or a neoplastic disorder comprising administering a Dipyrrole Compound. The compounds, compositions, and methods of the invention are also useful for inhibiting the growth of a cancer cell or neoplastic cell, treating or preventing a viral infection, or inhibiting the replication and/or infectivity of a virus. The invention also provides screening assays for compounds that can be used in combination with Dipyrrole Compounds for the treatment of cancer or neoplastic disease, inhibition of cancer cell growth, or treatment of viral infections.

公开(公告)号：EP1853255A1

公开(公告)日：2007-11-14

申请号：EP06705185.4

申请日：2006-02-16

申请人： Gemin X Biotechnologies Inc.

发明人： VIALLET, Jean

IPC分类号： A61K31/404 ,  A61P19/02 ,  A61K31/41

CPC分类号： A61K31/404 ,  A61K31/41 ,  Y02A50/401

摘要： The present invention relates to methods for treating or preventing arthritis comprising administering a Triheterocyclic Compound. In one embodiment, the present invention relates to methods of using Triheterocyclic Compounds for treating or preventing rheumatoid arthritis comprising administering a Triheterocyclic Compound.

公开(公告)号：EP1255753A2

公开(公告)日：2002-11-13

申请号：EP01902193.0

申请日：2001-01-24

申请人： Gemin X Biotechnologies Inc.

发明人： MURTHY, Madiraju, S., R. ,  STEENAART, Nancy, A., E. ,  JOHNSON, Roy, A. ,  SHORE, Gordon, C.

IPC分类号： C07D403/14 ,  A61K31/40 ,  A61P31/00 ,  A61P35/00

CPC分类号： C07D403/14 ,  C07D207/44

摘要： The present invention relates to novel Pyrrole-Type compounds, compositions comprising Pyrrole-Type compounds, and methods useful for treating or preventing cancer or a neoplastic disorder comprising administering a composition comprising a Pyrrole-Type compound. The compounds, compositions, and methods of the invention are also useful for inhibiting the growth of a cancer cell or neoplastic cell. The present invention also relates to novel Pyrrole-Type compounds, compositions, and methods useful for treating or preventing a viral infection. The compounds, compositions, and methods of the invention are also useful for inhibiting the replication and/or infectivity of a virus.

公开(公告)号：EP1644363A1

公开(公告)日：2006-04-12

申请号：EP04735171.3

申请日：2004-05-28

申请人： Gemin X Biotechnologies Inc.

发明人： ATTARDO, Giorgio ,  DAIRI, Kenza ,  LAVALLEE, Jean-Francois ,  RIOUX, Elise ,  TRIPATHY, Sasmita ,  BILLOT, Xavier ,  DOYLE, Terrence, W.

IPC分类号： C07D403/14 ,  A61K31/404 ,  C07D403/04 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D491/04 ,  C07F9/09 ,  C07F9/12

CPC分类号： C07D403/14 ,  C07D403/04 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D491/04 ,  C07F9/65583

摘要： The present invention relates to novel Triheterocyclic Compounds, formula (I): and pharmaceutically acceptable salts thereof, where in: Q1 is -O-, -S- or -N(R1)-; Q2 is -C(R3)- or -N-; Q3 is -C (R5)- or -N-; Q4 is -C (R9)- or -N-; compositions comprising a Triheterocyclic Compound, and methods useful for treating or preventing cancer or a neoplastic disorder comprising administering a Triheterocyclic Compound. The compounds, compositions, and methods of the invention are also useful for inhibiting the growth of a cancer cell or neoplastic cell, treating or preventing a viral infection, or inhibiting the replication and/or infectivity of a virus.

公开(公告)号：EP1431286A3

公开(公告)日：2004-07-28

申请号：EP04003643.6

申请日：2001-01-24

申请人： Gemin X Biotechnologies Inc.

发明人： Murthy, Madiraju S. R. ,  Steenaart, Nancy A.E. ,  Johnson, Roy A. ,  Shore, Gordon C.

IPC分类号： C07D207/44 ,  A61K31/40

CPC分类号： C07D403/14 ,  C07D207/44

摘要： The present invention relates to the use of the compounds of formula (V) or a pharmaceutically acceptable salt thereof for preparing a pharmaceutical composition for treating or preventing cancer or a neoplastic disease in a patient.

摘要翻译： 本发明涉及式（V）化合物或其药学上可接受的盐在制备用于治疗或预防患者中的癌症或肿瘤性疾病的药物组合物中的用途。

公开(公告)号：EP1431286A2

公开(公告)日：2004-06-23

申请号：EP04003643.6

申请日：2001-01-24

申请人： Gemin X Biotechnologies Inc.

发明人： The designation of the inventor has not yet been filed

IPC分类号： C07D207/44 ,  A61K31/40

CPC分类号： C07D403/14 ,  C07D207/44

摘要： The present invention relates to novel Pyrrole-Type compounds, compositions comprising Pyrrole-Type compounds, and methods useful for treating or preventing cancer or a neoplastic disorder comprising administering a composition comprising a Pyrrole-Type compound. The compounds, compositions, and methods of the invention are also useful for inhibiting the growth of a cancer cell or neoplastic cell. The present invention also relates to novel Pyrrole-Type compounds, compositions, and methods useful for treating or preventing a viral infection. The compounds, compositions, and methods of the invention are also useful for inhibiting the replication and/or infectivity of a virus.

摘要翻译： 本发明涉及式（V）化合物或其药学上可接受的盐在制备用于治疗或预防患者的癌症或肿瘤性疾病的药物组合物中的用途。