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1.发明公开
公开(公告)号：EP2797942A4
公开(公告)日：2015-06-03
申请号：EP12863426
申请日：2012-09-14
IPC分类号： C07H3/00
CPC分类号： A61K31/715 , A61K31/738 , A61K45/06 , C08B37/0045 , C08B37/006
摘要： Aspects of the invention provide compositions for use in the treatment galectin-dependent diseases. In particular, compositions comprising a selectively depolymerized, branched galactoarabino-rhamnogalacturonate whose backbone is predominantly comprised of 1,4-linked galacturonic acid (GalA) moieties, with a lesser backbone composition of alternating 1,4-linked GalA and 1,2-linked rhamnose (Rha), which in-turn is linked to any number of side chains, including predominantly 1,4-b-D-galactose (Gal) and 1,5-a-L-arabinose (Ara) residues.
摘要翻译： 本发明的方面，用于治疗半乳凝素依赖性疾病中的用途提供了组合物。 特别地，组合物包括选择性解聚，支galactoarabino-rhamnogalacturonate其主链主要是由1,4-连接的半乳糖醛酸（半乳糖）的部分，具有交替的较少骨架组成1,4-连接的半乳糖和1,2-连接的 鼠李糖（鼠李糖），后者又被连接到任意数量的侧链，包括主要为1,4-BD-半乳糖（Gal）和1,5-α-阿拉伯糖（ARA）的残基。
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公开(公告)号：EP2858651B1
公开(公告)日：2020-11-11
申请号：EP13800900.6
申请日：2013-06-06
IPC分类号： A61K31/736 , A61K31/738 , A61K31/732 , A61K31/715 , A61K45/06 , A61P43/00 , A61P37/00 , A61P25/28 , A61P9/00 , A61P1/16 , A61P29/00
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公开(公告)号：EP2900061B1
公开(公告)日：2020-01-22
申请号：EP13837458.2
申请日：2013-09-17
申请人： Galectin Therapeutics Inc. , Providence Health & Services Oregon d/b/a Earle A. Chiles Research Institute of the Robert W. Franz Cancer Res. Cent. at Providence Port. Med. Cen.
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4.发明公开METHOD FOR ENHANCING SPECIFIC IMMUNOTHERAPIES IN CANCER TREATMENT 审中-公开VERFAHREN ZUR OPTIMIERUNG SPEZIFISCHER IMMUNTHERAPIEN在DER KREBSBEHANDLUNG
公开(公告)号：EP2900061A1
公开(公告)日：2015-08-05
申请号：EP13837458.2
申请日：2013-09-17
申请人： Galectin Therapeutics Inc. , Providence Health & Services Oregon d/b/a Earle A. Chiles Research Institute of the Robert W. Franz Cancer Res. Cent. at Providence Port. Med. Cen.
发明人： TRABER, Peter, G. , REDMOND, William,L. , ZOMER, Eliezer , KLYOSOV, Anatole , LINCH, Stefanie, N.
摘要： Methods and compositions of the invention relate to the enhancement of specific immunotherapies in cancer treatment. In particular, aspects of the invention relate to novel approaches to boost immune function using a complex carbohydrate pharmaceutical compound alone or in combination with other targeted immunotherapy to increase the efficacy of immunotherapy of cancer.
摘要翻译： 本发明的方法和组合物涉及增强癌症治疗中的特异性免疫治疗。 特别地，本发明的方面涉及使用单独的复合碳水化合物药物化合物或与其它靶向免疫治疗组合来增强免疫功能以增加癌症免疫治疗功效的新方法。
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公开(公告)号：EP2906227B1
公开(公告)日：2018-10-03
申请号：EP13844631.5
申请日：2013-10-10
发明人： TRABER, Peter, G. , ZOMER, Eliezer
IPC分类号： A61K31/715
CPC分类号： C08B37/006 , A61K31/7105 , A61K31/715 , A61K38/02 , A61K45/06 , C08B37/0045 , A61K2300/00
摘要： Methods and compositions of the invention relate to the treatment of diabetic nephropathy and associated disorders. In particular, the methods and compositions use a pharmaceutical-grade galactose-pronged carbohydrate or pharmaceutical compositions thereof alone or in combination with other therapeutic agents.
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6.发明公开GALACTO-RHAMNOGALACTURONATE COMPOSITIONS FOR THE TREATMENT OF NON-ALCOHOLIC STEATOHEPATITIS AND NON-ALCOHOLIC FATTY LIVER DISEASE 审中-公开用于治疗非酒精性脂肪性肝炎与非酒精相关性GREASE半乳RHAMNOGALACTURONAT组合物
公开(公告)号：EP2755480A4
公开(公告)日：2015-04-29
申请号：EP12831657
申请日：2012-09-14
发明人： TRABER PETER G , ZOMER ELIEZER , KLYOSOV ANATOLE A
IPC分类号： A61K31/736 , A61K31/732 , A61P1/16 , A61P43/00
CPC分类号： C08B37/0045 , A61K31/732 , A61K31/736 , A61K45/06 , C08B37/006 , C08B37/0087 , A61K2300/00
摘要： Aspects of the invention provides provide methods for treatment of NASH and associated liver fibrosis. In particular, aspects of the invention relate to the therapeutic formulation comprising a galactomannan polysaccharide compound for the treatment of NASH and associated liver fibrosis.
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7.发明公开
公开(公告)号：EP2797942A1
公开(公告)日：2014-11-05
申请号：EP12863426.8
申请日：2012-09-14
IPC分类号： C07H3/00
CPC分类号： A61K31/715 , A61K31/70 , A61K31/738 , A61K45/06 , A61P1/16 , A61P11/00 , A61P35/00 , A61P37/00 , C08B37/0045 , C08B37/006
摘要： Aspects of the invention provide compositions for use in the treatment galectin-dependent diseases. In particular, compositions comprising a selectively depolymerized, branched galactoarabino-rhamnogalacturonate whose backbone is predominantly comprised of 1,4-linked galacturonic acid (GalA) moieties, with a lesser backbone composition of alternating 1,4-linked GalA and 1,2-linked rhamnose (Rha), which in-turn is linked to any number of side chains, including predominantly 1,4-b-D-galactose (Gal) and 1,5-a-L-arabinose (Ara) residues.
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公开(公告)号：EP2797942B1
公开(公告)日：2018-10-31
申请号：EP12863426.8
申请日：2012-09-14
CPC分类号： A61K31/715 , A61K31/70 , A61K31/738 , A61K45/06 , A61P1/16 , A61P11/00 , A61P35/00 , A61P37/00 , C08B37/0045 , C08B37/006
摘要： Aspects of the invention provide compositions for use in the treatment galectin-dependent diseases. In particular, compositions comprising a selectively depolymerized, branched galactoarabino-rhamnogalacturonate whose backbone is predominantly comprised of 1,4-linked galacturonic acid (GalA) moieties, with a lesser backbone composition of alternating 1,4-linked GalA and 1,2-linked rhamnose (Rha), which in-turn is linked to any number of side chains, including predominantly 1,4-b-D-galactose (Gal) and 1,5-a-L-arabinose (Ara) residues.
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公开(公告)号：EP2900061A4
公开(公告)日：2016-07-06
申请号：EP13837458
申请日：2013-09-17
申请人： GALECTIN THERAPEUTICS INC , PROVIDENCE HEALTH & SERVICES OREGON D B A EARLE A CHILES RES INST OF THE ROBERT W FRANZ CANCER RES C
CPC分类号： A61K47/26 , A61K9/0019 , A61K39/39558 , A61K2039/505 , C07K16/2818 , C07K16/2878 , C07K16/3069 , A61K2300/00
摘要： Methods and compositions of the invention relate to the enhancement of specific immunotherapies in cancer treatment. In particular, aspects of the invention relate to novel approaches to boost immune function using a complex carbohydrate pharmaceutical compound alone or in combination with other targeted immunotherapy to increase the efficacy of immunotherapy of cancer.
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10.发明公开GALACTO-RHAMNOGALACTURONATE COMPOSITIONS FOR THE TREATMENT OF DISEASES ASSOCIATED WITH ELEVATED INDUCIBLE NITRIC OXIDE SYNTHASE 审中-公开GALACTORHAMNOGALACTURONATZUSAMMENSETZUNGEN FOR疾病治疗具有增加诱导型一氧化氮合酶相关
公开(公告)号：EP2858651A4
公开(公告)日：2016-02-17
申请号：EP13800900
申请日：2013-06-06
发明人： TRABER PETER G , ZOMER ELIEZER , KLYOSOV ANATOLE A
IPC分类号： A61K31/736 , A61K31/715 , A61K31/732 , A61K31/738 , A61K45/06 , A61P1/16 , A61P9/00 , A61P25/28 , A61P29/00 , A61P37/00 , A61P43/00
CPC分类号： A61K31/738 , A61K31/715 , A61K31/736 , A61K45/06 , A61K2300/00
摘要： Aspects of the invention provide methods for treatment of a disease associated with elevated iNOS including autoimmune, chronic inflammatory, neurodegenerative, or cardiovascular diseases. In particular, aspects of the invention relate to the use of a therapeutic formulation comprising a galacto-rhamnogalacturonate for the treatment of a disease associated with elevated iNOS including autoimmune, chronic inflammatory, neurodegenerative, or cardiovascular diseases.
摘要翻译： 本发明的方面提供了用于治疗与升高的iNOS包括自身免疫性，慢性炎症，神经变性，或心血管疾病相关的疾病的方法。 特别地，本发明的方面涉及使用治疗制剂，其包含低聚半rhamnogalacturonate针对与高iNOS的包括自身免疫性，慢性炎症，神经变性，或心血管疾病相关的疾病的治疗的。
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