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1.发明公开PRODRUGS OF A 7-ACYLAMINO-3-HETEROARYLTHIO-3-CEPHEM CARBOXYLIC ACID ANTIBIOTIC 审中-公开A 7酰氨基-3-杂-3-头孢烯抗生素CARBOXYLIC前药的
公开(公告)号：EP1320533A1
公开(公告)日：2003-06-25
申请号：EP01918879.6
申请日：2001-03-20
申请人： Essential Therapeutics, Inc. , Hecker, Scott J. , Cho, Aesop , Glinka, Tomasz W. , Calkins, Trevor , Lee, Ving J.
IPC分类号： C07D501/59 , A61K31/546 , A61P31/04
CPC分类号： C07D501/00
摘要： The present invention relates to prodrugs of the antibiotic compound (7R)-7-[(Z)-2-(2-amino-5-chlorothiazol-4-yl)-2-(hydroxylimino)acetamido]acetamidol]-3-{3-(2-aminoethylthiomethyl]-pyrid-4-ylthio}-3-cephem-4-carbocyllic acid, where the prodrugs are substantially more water soluble at or near neutral pH than the parent compound.
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2.发明公开PRODRUGS OF A 7-ACYLAMINO-3-HETEROARYLTHIO-3-CEPHEM CARBOXYLIC ACID ANTIBIOTIC 审中-公开A 7酰氨基-3-杂-3-头孢烯抗生素CARBOXYLIC前药的
公开(公告)号：EP1320533A4
公开(公告)日：2004-12-15
申请号：EP01918879
申请日：2001-03-20
申请人： ESSENTIAL THERAPEUTICS INC , HECKER SCOTT J , CHO AESOP , GLINKA TOMASZ W , CALKINS TREVOR , LEE VING J
发明人： HECKER SCOTT J , CHO AESOP , GLINKA TOMASZ W , CALKINS TREVOR , LEE VING J
IPC分类号： A61K31/546 , A61P31/04 , A61P43/00 , C07D501/00 , C07D501/59
CPC分类号： C07D501/00
摘要： The present invention relates to prodrugs of the antibiotic compound (7R)-7-[(Z)-2-(2-amino-5-chlorothiazol-4-yl)-2-(hydroxylimino)acetamido]acetamidol]-3-{3-(2-aminoethylthiomethyl]-pyrid-4-ylthio}-3-cephem-4-carbocyllic acid, where the prodrugs are substantially more water soluble at or near neutral pH than the parent compound.
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