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公开(公告)号：EP0938571B8
公开(公告)日：2008-07-02
申请号：EP97948802.0
申请日：1997-10-24
申请人： University of Lausanne , Swiss Institute for Allergy and Asthma Research , INSTITUT SUISSE DE RECHERCHES EXPERIMENTALES SUR LE CANCER ISREC , Novartis Pharma GmbH
CPC分类号： C07K14/78 , C07K19/00 , C07K2319/00 , C07K2319/21 , C07K2319/73 , C12N15/62
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公开(公告)号：EP0938571B1
公开(公告)日：2008-05-07
申请号：EP97948802.0
申请日：1997-10-24
申请人： Novartis AG , University of Lausanne , Swiss Institute for Allergy and Asthma Research , INSTITUT SUISSE DE RECHERCHES EXPERIMENTALES SUR LE CANCER ISREC , Novartis Pharma GmbH
CPC分类号： C07K14/78 , C07K19/00 , C07K2319/00 , C07K2319/21 , C07K2319/73 , C12N15/62
摘要： The present invention concerns an oligomer comprising more than 2 units, wherein each unit comprises a peptidic domain capable of oligomerizing and a domain capable of binding to an acceptor (ligand), wherein the oligomerizing domain is not an antibody or a functional antibody fragment from the constant region. Also described is the use and synthesis of this oligomer.
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公开(公告)号：EP0938571A1
公开(公告)日：1999-09-01
申请号：EP97948802.0
申请日：1997-10-24
申请人： Novartis AG , University of Lausanne , Swiss Institute for Allergy and Asthma Research , INSTITUT SUISSE DE RECHERCHES EXPERIMENTALES SUR LE CANCER ISREC
CPC分类号： C07K14/78 , C07K19/00 , C07K2319/00 , C07K2319/21 , C07K2319/73 , C12N15/62
摘要： The present invention concerns an oligomer comprising more than 2 units, wherein each unit comprises a peptidic domain capable of oligomerizing and a domain capable of binding to an acceptor (ligand), wherein the oligomerizing domain is not an antibody or a functional antibody fragment from the constant region. Also described is the use and synthesis of this oligomer.
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4.发明公开Secretory immunoglobulin A as a mucosal vaccine delivery system 失效Se ches ches ches ystem ystem ystem ystem ystem ystem ystem ystem ystem ystem ystem ystem
公开(公告)号：EP0839915A1
公开(公告)日：1998-05-06
申请号：EP96203051.6
申请日：1996-11-01
IPC分类号： C12N15/62 , C07K16/00 , C07K16/46 , C07K1/22 , A61K39/385 , A61K39/395
CPC分类号： A61K39/385 , A61K38/00 , A61K2039/6056 , C07K14/25 , C07K16/46 , C07K2318/10 , C07K2319/00
摘要： A secretory IgA antibody (sIgA) comprising a polymeric IgA antibody bound to a secretory component (SC) which SC comprises a (poly)peptide insert corresponding to a protective epitope of an antigen; a vaccine comprising such sIgA antibody; a DNA construct comprising a DNA sequence coding for a SC and a DNA insert coding for the protective epitope of an antigen; a method for producing said sIgA antibody; and a method for active immunization of a mammal which comprises administering to said mammal an effective amount of a vaccine comprising said sIgA.
摘要翻译： 包含与分泌组分（SC）结合的聚合IgA抗体的分泌型IgA抗体（sIgA），其中SC包含对应于抗原的保护性表位的（多）肽插入物; 包含这种sIgA抗体的疫苗; 包含编码SC的DNA序列和编码抗原的保护性表位的DNA插入物的DNA构建体; 制备所述sIgA抗体的方法; 和哺乳动物主动免疫的方法，其包括向所述哺乳动物施用有效量的包含所述sIgA的疫苗。
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