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    METHOD AND KIT FOR PREDICTING CERVICAL SHORTENING AND PRETERM BIRTH
    3.
    发明公开
    METHOD AND KIT FOR PREDICTING CERVICAL SHORTENING AND PRETERM BIRTH 审中-公开

    公开(公告)号：EP3839069A1

    公开(公告)日：2021-06-23

    申请号：EP20213489.6

    申请日：2016-03-07

    申请人： Imperial College of Science, Technology and Medicine

    发明人： COOK, Joanna ,  BENNETT, Phillip ,  TERZIDOU, Vasiliki ,  MACINTYRE, David

    IPC分类号： C12Q1/6883

    摘要： The present invention provides method for predicting risk of cervical shortening, methods for predicting risk of preterm labour (PTL), and methods for characterising a pregnant subject having a history of previous PTL, mid-trimester loss or cervical cone biopsy as being in need of surveillance and/or intervention to prevent preterm labour, comprising determining the expression level of mir-374a-5p, and one or more of the miRNA molecules identified in Table 1 or Table 2 extracted from a biological sample obtained from said subject and comparing to a control value. Use of biochips and kits for use in carrying out the methods of the invention are also provided.

    FLUID FLOW ANALYSIS
    9.
    发明公开
    FLUID FLOW ANALYSIS 审中-公开

    公开(公告)号：EP3659516A1

    公开(公告)日：2020-06-03

    申请号：EP20151464.3

    申请日：2017-03-17

    申请人： Imperial College of Science, Technology and Medicine

    发明人： Weinberg, Peter David

    IPC分类号： A61B8/06 ,  A61B8/08 ,  A61B5/026 ,  G01P5/24 ,  G01F1/66 ,  G01F1/708 ,  G01F1/72 ,  A61B5/107

    摘要： A method of determining a measure of wave speed or wave intensity in a fluid conduit comprises uses ultrasound measurements to determine the conduit diameter, as a function of time, at a longitudinal position of the conduit, and uses ultrasound measurements to determine fluid velocity, as a function of time, in a volume element at said longitudinal position of the conduit. The ultrasound measurement to determine fluid velocity is effected by tracking objects within the fluid flow in successive frames sampling the volume element, and obtaining displacement vectors for the objects. A wave speed may be determined from a ratio of the change in fluid velocity at the longitudinal position as a function of time and the change in a logarithmic function of the conduit diameter as a function of time. A measure of wave intensity may be determined as a function of change in determined conduit diameter and corresponding change in fluid velocity.