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公开(公告)号：EP4337679A2
公开(公告)日：2024-03-20
申请号：EP22808403.4
申请日：2022-05-13
申请人： Inspirna, Inc.
IPC分类号： C07K14/47 , A61K39/00 , G01N33/573 , A61K47/42 , C12N15/62
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公开(公告)号：EP4378958A3
公开(公告)日：2024-09-04
申请号：EP24156716.3
申请日：2020-02-25
申请人： Inspirna, Inc.
IPC分类号： A61P35/00 , C07K14/705 , C07K16/28
CPC分类号： A61P35/00 , C07K16/2818 , C07K16/2863 , C07K2317/2420130101 , C07K2317/3320130101 , C07K2317/7620130101 , C07K2317/9220130101
摘要： Provided herein is an antibody-drug conjugate, wherein the antibody-drug conjugate comprises (a) an antibody moiety that is an antibody or an antigen-binding fragment thereof that specifically binds to human Mer Tyrosine Kinase (MERTK), wherein the antibody or antigen-binding fragment comprises a heavy chain variable region (VH) and a light chain variable region (VL), wherein the VH comprises the amino acid sequence of SEQ ID NO: 105 and the VL comprises the amino acid sequence of SEQ ID NO: 106; and (b) one or more drug moieties, each drug moiety being a cytotoxic agent, and wherein the cytotoxic agent is monomethyl auristatin E (MMAE) or PNU-159682. Also provided is said antibody-drug conjugate for use in a method of treating cancer in a subject in need thereof and a pharmaceutical composition comprising comprising a population of said antibody-drug conjugates.
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公开(公告)号：EP4073025A1
公开(公告)日：2022-10-19
申请号：EP20897654.8
申请日：2020-12-11
申请人： Inspirna, Inc.
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公开(公告)号：EP4378958A2
公开(公告)日：2024-06-05
申请号：EP24156716.3
申请日：2020-02-25
申请人： Inspirna, Inc.
IPC分类号： C07K16/28
CPC分类号： A61P35/00 , C07K16/2818 , C07K16/2863 , C07K2317/2420130101 , C07K2317/3320130101 , C07K2317/7620130101 , C07K2317/9220130101
摘要： Provided herein is an antibody-drug conjugate, wherein the antibody-drug conjugate comprises (a) an antibody moiety that is an antibody or an antigen-binding fragment thereof that specifically binds to human Mer Tyrosine Kinase (MERTK), wherein the antibody or antigen-binding fragment comprises a heavy chain variable region (VH) and a light chain variable region (VL), wherein the VH comprises the amino acid sequence of SEQ ID NO: 105 and the VL comprises the amino acid sequence of SEQ ID NO: 106; and (b) one or more drug moieties, each drug moiety being a cytotoxic agent, and wherein the cytotoxic agent is monomethyl auristatin E (MMAE) or PNU-159682. Also provided is said antibody-drug conjugate for use in a method of treating cancer in a subject in need thereof and a pharmaceutical composition comprising comprising a population of said antibody-drug conjugates.
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公开(公告)号：EP3930847A1
公开(公告)日：2022-01-05
申请号：EP20714383.5
申请日：2020-02-25
申请人： Inspirna, Inc.
IPC分类号： A61P35/00 , C07K14/705 , C07K16/28
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公开(公告)号：EP4373582A1
公开(公告)日：2024-05-29
申请号：EP22846790.8
申请日：2022-07-19
申请人： Inspirna, Inc.
发明人： TAVAZOIE, Masoud , KURTH, Isabel , DARST, David
IPC分类号： A61P35/00 , A61K31/155 , A61K31/4985
CPC分类号： A61P35/00 , A61K31/519 , A61K31/195
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公开(公告)号：EP4072561A1
公开(公告)日：2022-10-19
申请号：EP20899002.8
申请日：2020-12-10
申请人： Inspirna, Inc.
IPC分类号： A61K31/7072
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公开(公告)号：EP4027989A1
公开(公告)日：2022-07-20
申请号：EP20862691.1
申请日：2020-09-10
申请人： Inspirna, Inc.
IPC分类号： A61K31/138 , C07C217/18
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公开(公告)号：EP3950673A1
公开(公告)日：2022-02-09
申请号：EP21182284.6
申请日：2015-04-30
申请人： Inspirna, Inc.
IPC分类号： C07D205/04 , C07C261/00 , C07C269/00 , C07C277/00 , C07C279/00 , C07D207/16 , C07D205/08 , C07D207/22 , A61P35/00 , C07D213/74 , C07D213/76 , C07D231/12 , C07D233/26 , C07D233/46 , C07D233/52 , C07D233/64 , C07D233/88 , C07D239/06 , C07D239/14 , C07D249/14 , C07D253/06
摘要： This invention relates to compounds that inhibit creatine transport and/or creatine kinase, pharmaceutical compositions including such compounds, and methods of utilizing such compounds and compositions for the treatment of cancer.
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