公开(公告)号：EP1603571A2

公开(公告)日：2005-12-14

申请号：EP04720024.1

申请日：2004-03-12

申请人： Vihko, Pirkko ,  Isomaa, Veli

发明人： Vihko, Pirkko ,  Isomaa, Veli

IPC分类号： A61K31/519 ,  G01N33/68 ,  A61P35/00

CPC分类号： C07D495/14 ,  A61K31/519 ,  A61K31/554 ,  G01N33/57415 ,  G01N2333/902

摘要： This invention concerns in vitro method for prognosticating the progress of breast cancer, comprising detecting or quantifying the level of 17β-hydroxysteroid dehydrogenase (17HSD) type 1 enzyme in breast tumor tissue sample, wherein the presence of said 17HSD type 1 enzyme is indicative of severe progress of breast cancer. Furthermore, the invention also concerns the use of a 17HSD type 1 enzyme inhibitor for prevention or treatment of breast cancer. This invention concerns also the use of compound A in the manufacture of a pharmaceutically acceptable preparation useful as 17HSD inhibitor.