公开(公告)号：EP3362480A1

公开(公告)日：2018-08-22

申请号：EP16873228.7

申请日：2016-11-02

申请人： Isu Abxis Co., Ltd.

发明人： BAE, Dong Goo ,  KIM, Mi Young ,  HUR, Young Mi ,  HONG, Mi Rim

IPC分类号： C07K16/32 ,  A61K39/395

CPC分类号： A61K39/39558 ,  A61K2039/505 ,  A61K2039/507 ,  A61K2039/545 ,  C07K16/2863 ,  C07K16/32 ,  C07K2317/21 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  A61K2300/00

摘要： An antibody that specifically binds to ErbB3 or an antigen-binding fragment thereof, and use thereof, are provided. The antibody that specifically binds to ErbB3 or an antigen-binding fragment thereof may be effectively used to prevent or treat a disease related to activation or overexpression of ErbB3 protein.

公开(公告)号：EP4349865A1

公开(公告)日：2024-04-10

申请号：EP22811661.2

申请日：2022-05-26

申请人： Isu Abxis Co., Ltd. ,  Kyungpook National University Industry-Academic Cooperation Foundation

发明人： HONG, Seung Beom ,  BAE, Jae Sung ,  JIN, Hee Kyung

IPC分类号： C07K16/40 ,  A61P25/28 ,  A23L33/18 ,  A61K39/00

摘要： Disclosed is use of an antibody or antigen-binding fragment thereof that specifically binds to an acid sphingomyelinase (ASM) protein, wherein the antibody or antigen-binding fragment thereof specifically binds to an ASM protein with high binding affinity, significantly inhibits the activity of an ASM protein present in the cellular membrane, and shows effects of improving cognitive memory, inhibiting ASM protein activity, inhibiting the accumulation of amyloid-β and tau proteins, and inhibiting the production of neuroinflammation even without toxicity in Alzheimer's disease animal models, and thus can be advantageously used in the treatment of a brain disease.

公开(公告)号：EP1957526A1

公开(公告)日：2008-08-20

申请号：EP05819136.2

申请日：2005-12-20

申请人： Isu Abxis Co., Ltd.

发明人： KIM, Myung Kyung ,  CHUNG, Jay Hang

IPC分类号： C07K14/47

CPC分类号： C07K14/4703

摘要： Disclosed are molecules inhibiting intercellular adhesion during inflammation and the use of these molecules in the treatment of inflammatory diseases.

公开(公告)号：EP3778647A1

公开(公告)日：2021-02-17

申请号：EP20196712.2

申请日：2016-11-02

申请人： Isu Abxis Co., Ltd.

发明人： BAE, Dong Goo ,  KIM, Mi Young ,  HUR, Young Mi ,  HONG, Mi Rim

IPC分类号： C07K16/32 ,  C07K16/28 ,  A61K39/395 ,  A61K31/00 ,  A61P35/00

摘要： An antibody that specifically binds to ErbB3 or an antigen-binding fragment thereof, and use thereof, are provided. The antibody that specifically binds to ErbB3 or an antigen-binding fragment thereof may be effectively used to prevent or treat a disease related to activation or overexpression of ErbB3 protein.

公开(公告)号：EP1957526B1

公开(公告)日：2013-06-26

申请号：EP05819136.2

申请日：2005-12-20

申请人： Isu Abxis Co., Ltd.

发明人： KIM, Myung Kyung ,  CHUNG, Jay Hang

IPC分类号： C07K14/47

CPC分类号： C07K14/4703

公开(公告)号：EP1957526A4

公开(公告)日：2009-03-11

申请号：EP05819136

申请日：2005-12-20

申请人： ISU ABXIS CO LTD

发明人： KIM MYUNG KYUNG ,  CHUNG JAY HANG

IPC分类号： C07K14/47

CPC分类号： C07K14/4703

摘要： Disclosed are molecules inhibiting intercellular adhesion during inflammation and the use of these molecules in the treatment of inflammatory diseases.

公开(公告)号：EP4349866A1

公开(公告)日：2024-04-10

申请号：EP22811711.5

申请日：2022-05-26

申请人： Isu Abxis Co., Ltd.

发明人： HONG, Seung Beom ,  HONG, Mi Rim

IPC分类号： C07K16/40 ,  G01N33/68 ,  C12N15/85

摘要： The present disclosure relates to an antibody specifically binding to an acid sphingomyelinase (ASM) protein and, specifically, the antibody or antigen-binding fragment according to the present disclosure specifically binds to an ASM protein with high affinity and thus can be advantageously used in detecting the ASM protein or diagnosing a disease occurring due to the over-expression of the ASM protein.

公开(公告)号：EP2038304A4

公开(公告)日：2010-01-20

申请号：EP07873292

申请日：2007-06-20

申请人： ISU ABXIS CO LTD

发明人： KIM MYUNG ,  CHUNG JAY ,  PARK JUNE-YOUNG ,  YOO HYOUNA ,  LEE SANG-MIN ,  LEE YOON-SEOK ,  KOO MISON ,  PARK SANG-HO ,  LEE JUHENG ,  HUR YOUNG MI

IPC分类号： C07K16/00

CPC分类号： C07K16/2896 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2319/30

摘要： The application disclose a method of preventing immune cells from binding to other cells, which includes contacting the immune cells and the other cells with a composition comprising Bst2 antagonist.

公开(公告)号：EP2038304A1

公开(公告)日：2009-03-25

申请号：EP07873292.2

申请日：2007-06-20

申请人： Isu Abxis Co., Ltd ,  Kim, Myung ,  Chung, Jay ,  Park, June-Young ,  Yoo, Hyouna ,  Lee, Sang-Min ,  Lee, Yoon-Seok ,  Koo, Mison ,  Park, Sang-Ho ,  Lee, Juheng ,  Hur, Young Mi

发明人： KIM, Myung ,  CHUNG, Jay ,  PARK, June-Young ,  YOO, Hyouna ,  LEE, Sang-Min ,  LEE, Yoon-Seok ,  KOO, Mison ,  PARK, Sang-Ho ,  LEE, Juheng ,  HUR, Young Mi

IPC分类号： C07K16/00

CPC分类号： C07K16/2896 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2319/30 ,  Y02A50/466

摘要： The application disclose a method of preventing immune cells from binding to other cells, which includes contacting the immune cells and the other cells with a composition comprising Bst2 antagonist.