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1.发明授权Pharmaceutical compositions for oral administration containing a gastroresistant coating based on acrylic polymers 有权基于丙烯酸酯的聚合物用于口服给药的药物组合物含有耐胃液的涂层
公开(公告)号：EP1004297B1
公开(公告)日：2006-01-11
申请号：EP99122470.0
申请日：1999-11-11
IPC分类号： A61K9/20 , A61K9/32 , A61K31/606
CPC分类号： A61K31/606 , A61K9/205 , A61K9/2846
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2.发明公开Gamma-hydroxybutyric acid salts possessing anxiolytic activity and suitable for the treatment of states of depression 失效-γ-羟基Bultersäuresalze具有抗焦虑作用并适用于抑郁状态的治疗中。
公开(公告)号：EP0616804A1
公开(公告)日：1994-09-28
申请号：EP94104577.5
申请日：1994-03-23
IPC分类号： A61K31/19
CPC分类号： A61K31/19
摘要： Use of pharmaceutically acceptable salts of gamma-hydroxybutyric acid as active ingredients for the preparation of pharmaceutical compositions possessing anxiolytic activity and suitable for the treatment of states of depression.
摘要翻译： 用于药物组合物的一团的制备γ-羟酸作为活性成分的药学上可接受的盐的用途唱抗焦虑活性和适用于抑郁症的状态的治疗。
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3.发明授权
公开(公告)号：EP3331853B1
公开(公告)日：2019-12-11
申请号：EP16791313.6
申请日：2016-08-03
IPC分类号： C07C235/06 , A61K31/16 , A61P25/32
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4.发明公开POLYMORPHIC FORM OF N-[4-(TRIFLUOROMETHILBENZYL]-4-METHOXYBUTYRAMIDE 审中-公开多晶型N- [4-（三氟甲基苄基）-4-甲氧基丁基]
公开(公告)号：EP3012246A1
公开(公告)日：2016-04-27
申请号：EP15192055.0
申请日：2008-11-12
IPC分类号： C07C235/06 , A61K31/165 , A61P25/30
CPC分类号： C07C235/06 , C07B2200/13
摘要： Crystalline polymorphic form of a compound of formula N-[4-(trifluoromethyl)benzyl]-4-methoxybutyramide is described. The polymorphic form, named polymorphic Form B, can be used in the treatment of drug addiction and alcoholism and have very good stability. Methods for preparing the polymorphic form are also described.
摘要翻译： 描述式N- [4-（三氟甲基）苄基] -4-甲氧基丁酰胺的化合物的结晶多晶型物。 多形态B型多形态可用于治疗药物成瘾和酒精中毒，并具有很好的稳定性。 还描述了制备多晶型形式的方法。
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5.发明公开New polymorphic forms of n-[4-(trifluoromethyl)benzyl]-4-methoxybutyramide 审中-公开Neue polymorphe Formen von N- [4-（三氟甲基）苄基] -4-甲氧基丁酰胺
公开(公告)号：EP2062875A1
公开(公告)日：2009-05-27
申请号：EP07120551.2
申请日：2007-11-13
IPC分类号： C07C235/06 , A61K31/165 , A61P25/30
CPC分类号： C07C235/06 , C07B2200/13
摘要： Crystalline polymorphic forms of a compound of formula N-[4-(trifluoromethyl)benzyl]-4-methoxybutyramide are described. The two polymorphic forms, named polymorphic Form A and polymorphic Form B, can be used in the treatment of drug addiction and alcoholism and have very good stability. Methods for preparing the polymorphic forms are also described.
摘要翻译： 描述式N- [4-（三氟甲基）苄基] -4-甲氧基丁酰胺的化合物的结晶多晶型物。 两种多态形式，命名为多形态A型和多态性B型，可用于治疗药物成瘾和酒精中毒，并具有很好的稳定性。 还描述了制备多晶型物的方法。
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6.发明公开Use of gamma-hydroxybutyric acid salts for preparing pharmaceutical compositions for use in the treatment of alcoholism, and the compositions obtained 失效使用的用于制备药物组合物用于治疗酒精中毒使用γ-羟丁酸的盐，以及制备该组合物。
公开(公告)号：EP0344704A1
公开(公告)日：1989-12-06
申请号：EP89109712.3
申请日：1989-05-30
IPC分类号： A61K31/19
CPC分类号： A61K31/19 , Y10S514/811
摘要： The use of gamma-hydroxybutyric acid salts for preparing pharmaceutical compositions useful for the release form ethyl alcohol consumption and the conpositions obtained.
摘要翻译： 一种制备用于释放形式的乙醇消耗有用和药物组合物获得的conpositions使用γ-羟丁酸的盐。
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7.发明公开
公开(公告)号：EP3331853A1
公开(公告)日：2018-06-13
申请号：EP16791313.6
申请日：2016-08-03
IPC分类号： C07C235/06 , A61K31/16 , A61P25/32
摘要： The present invention relates to a selected amide of γ-hydroxybutyric acid, a process of manufacture and uses thereof. The invention also includes a pharmaceutical composition comprising an effective amount of the selected compound of the invention for use in preventing or treating drug addiction, especially alcohol misuse or dependency.
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8.发明公开NEW POLYMORPHIC FORMS OF N-Ý4-(TRIFLUOROMETHYL)BENZYL¨-4-METHOXYBUTYRAMIDE 有权N- [4-（三氟甲基）苯甲基] -4- METHOXYBUTYRAMID的多晶型形式
公开(公告)号：EP2220027A1
公开(公告)日：2010-08-25
申请号：EP08849561.9
申请日：2008-11-12
IPC分类号： C07C235/06 , A61K31/165 , A61P25/30
CPC分类号： C07C235/06 , C07B2200/13
摘要： Crystalline polymorphic forms of a compound of formula N-[4-(trifluoromethyl)benzyl]-4-methoxybutyramide are described. The two polymorphic forms, named polymorphic Form A and polymorphic Form B, can be used in the treatment of drug addiction and alcoholism and have very good stability. Methods for preparing the polymorphic forms are also described.
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9.发明授权PHARMACEUTICAL COMPOSITION CONTAINING GAMMA-HYDROXYBUTYRIC ACID OR ITS LACTONE IN THE TREATMENT OF DRUG DEPENDENCE AND NUTRITIONAL DISORDERS 失效药物组合物和伽马羟基丁酸或相应的内酯的含有药物成瘾和营养障碍的治疗
公开(公告)号：EP0563336B1
公开(公告)日：2001-08-22
申请号：EP92912485.7
申请日：1992-06-23
申请人： CREPALDI, Gaetano , FERRARA, Santo , GALLIMBERTI, Luigi , GESSA, Gian Luigi , LABORATORIO FARMACEUTICO C.T. S.r.l.
IPC分类号： A61K31/19 , A61K31/365
CPC分类号： A61K31/365 , A61K31/19 , Y10S514/81 , Y10S514/811 , Y10S514/812 , Y10S514/813 , Y10S514/909 , Y10S514/91
摘要： gamma -Hydroxybutyric acid and its physiologically equivalent forms are useful in the treatment of the syndromes of abstinence, craving and dependence on drugs, drugs of abuse, psychotropics, stupefacient and/or psychoactive substances, nicotine, or nutrition disorders.
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10.发明授权Controlled release pharmaceutical compositions based on one or more pharmaceutically acceptable salts of gamma hydroxy-butyric acid 失效的γ-羟丁酸的一种或多种药学上可接受的盐的基础上的药物的控制释放组合物
公开(公告)号：EP0635265B1
公开(公告)日：2000-02-02
申请号：EP94111279.9
申请日：1994-07-20
CPC分类号： A61K9/2054 , A61K9/2846 , A61K31/19 , Y10S514/811 , Y10S514/812 , Y10S514/813
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