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公开(公告)号：EP3740190A1
公开(公告)日：2020-11-25
申请号：EP19700411.2
申请日：2019-01-15
申请人： Leukos Biotech, S.L.
IPC分类号： A61K9/00 , A61K47/02 , A61K9/10 , A61K31/473 , C07D221/18 , A61P25/00 , A61P35/02
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公开(公告)号：EP3568136A1
公开(公告)日：2019-11-20
申请号：EP18701134.1
申请日：2018-01-15
申请人： Leukos Biotech, S.L.
IPC分类号： A61K31/473 , A61K31/4965 , A61K31/706 , A61K31/7068
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公开(公告)号：EP3348266A1
公开(公告)日：2018-07-18
申请号：EP17382015.0
申请日：2017-01-16
申请人： Leukos Biotech, S.L.
IPC分类号： A61K31/473 , A61K31/4965 , A61K31/706 , A61K31/7068
CPC分类号： A61K31/473 , A61K31/4965 , A61K31/706 , A61K31/7068 , A61K2300/00
摘要： The invention relates to a combination comprising an antineoplastic agent, e.g. an antimetabolite antineoplastic agent and a serotonin receptor (HTR) modulator, e.g. a HTR antagonist. In addition the invention relates to a pharmaceutical composition comprising a combination of the invention and a pharmaceutically acceptable excipient. The invention also relates to the combination and pharmaceutical composition according to the invention for use in medicine, particularly for use in the prevention and/or treatment of a hematological malignancy.
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公开(公告)号：EP4225753A1
公开(公告)日：2023-08-16
申请号：EP21789678.6
申请日：2021-10-07
发明人： CASTRO- PALOMINO LARIA, Julio , CAMACHO GÓMEZ, Juan Alberto , MUÑOZ RISUEÑO, Ruth , CLÉMENT-DEMANGE, Lise
IPC分类号： C07D413/10 , C07D413/12 , A61K31/455 , A61K31/497
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公开(公告)号：EP4445901A2
公开(公告)日：2024-10-16
申请号：EP24191411.8
申请日：2021-10-07
发明人： CASTRO- PALOMINO LARIA, Julio , CAMACHO GÓMEZ, Juan Alberto , MUÑOZ RISUEÑO, Ruth , CLÉMENT-DEMANGE, Lise
IPC分类号： A61K31/497
摘要： The present invention relates to new compounds of formula (I):
as modulators of serotonin receptor 1B (5-HTR 1B ) also known as 5-hydroxytryptamine receptor 1B (5-HT 1B ). The compounds are of potential utility in the treatment of diseases and conditions mediated by serotonin receptor type 1B (5-HTR 1B ), such as cancer, including blood cancer and solid tumors, respiratory diseases and hepatic disorders.
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