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    MICROFLUIDIC CARTRIGE WITH BUILT-IN SAMPLING DEVICE
    1.
    发明公开
    MICROFLUIDIC CARTRIGE WITH BUILT-IN SAMPLING DEVICE 审中-公开

    公开(公告)号：EP3459632A1

    公开(公告)日：2019-03-27

    申请号：EP17193351.8

    申请日：2017-09-26

    申请人： Lunaphore Technologies SA

    发明人： JORIS, Pierre ,  CAPPI, Giulia ,  AMMANN, Marco ,  COMINO, Marta ,  EROGLU, Deniz ,  DUPOUY, Diego ,  CIFTLIK, Ata Tuna

    IPC分类号： B01L3/00

    摘要： Microfluidic cartridge (10) comprising a sampling device (30) having a sealing ring (32) arranged to form a microfluidic chamber (31) when a support containing a biological sample is brought into contact with the sealing ring, and a microfluidic network device (13) configured to supply reagents to the microfluidic chamber. The sampling device further comprises inlet and outlet distribution networks (33a, 33b) in fluid communication with the microfluidic chamber and a slide holder (35) to guide and position said support containing a biological sample on the sampling device. The microfluidic network device comprises a plurality of reagent inlet channels (18) fluidly connectable to reagent sources, at least one reagent outlet channel (22) fluidly connected to the sampling device inlet distribution network (33a), and a plurality of valves (25) operable to selectively connect the inlet channels to the at least one outlet channel. The sampling device (30) and microfluidic network device (13) are formed on a common microfluidic support (12) as a single part.

    BIOLOGICAL SAMPLE PROCESSING SYSTEM AND MICROFLUIDIC CARTRIDGE THEREFOR
    2.
    发明公开
    BIOLOGICAL SAMPLE PROCESSING SYSTEM AND MICROFLUIDIC CARTRIDGE THEREFOR 审中-公开

    公开(公告)号：EP3798640A1

    公开(公告)日：2021-03-31

    申请号：EP19200101.4

    申请日：2019-09-27

    申请人： Lunaphore Technologies SA

    发明人： JORIS, Pierre ,  EROGLU, Deniz ,  DUPOUY, Diego ,  PELZ, Benjamin

    IPC分类号： G01N35/02 ,  G01N1/31 ,  B01L3/00 ,  G01N35/00

    摘要： Biological sample processing system comprising an imaging unit (2) comprising a digital image processing system and at least one microscope including at least one lens (14), a sample processing station (3) comprising a handling platform (3) including a support (17) and a displacement mechanism for moving the support (17), and a sample processing unit (7) mounted on the handling platform (5). The sample processing unit (7) comprises a tissue slide holder (11) for mounting thereon a tissue slide (34) with a biological sample (36) fixed thereon and a microfluidic cartridge holder (9) for mounting a microfluidic cartridge (4) thereon. The tissue slide holder (11) is coupled to the microfluidic cartridge holder (9) via a coupling (13) allowing the microfluidic cartridge and the tissue support to be mounted and removed from the sample processing unit in an opened position, and in a closed position for the tissue support (34) to be in sealing contact with the microfluidic cartridge (4). The sample processing station comprises a plurality of said sample processing units mounted on the handling platform (5) and moveable from a position allowing mounting of the tissue slide, respectively microfluidic cartridge, or removal thereof, to a position in which the viewing window in the microfluidic cartridge holder (9) is positioned in alignment with the lens of said at least one microscope.

    DIGITAL IMAGE PROCESSING SYSTEM
    6.
    发明公开
    DIGITAL IMAGE PROCESSING SYSTEM 审中-公开

    公开(公告)号：EP4375926A1

    公开(公告)日：2024-05-29

    申请号：EP22210031.5

    申请日：2022-11-28

    申请人： Lunaphore Technologies SA

    发明人： CASQUEIRO, Gilles ,  ARN, Lionel

    IPC分类号： G06T7/30 ,  G06T7/38

    CPC分类号： G06T7/30 ,  G06T7/38 ,  G06T2207/1005620130101 ,  G06T2207/1006420130101

    摘要： A digital image processing system configured for processing a plurality of image capture scans of a sample obtained from a microscope in a corresponding plurality of scan cycles, each image capture scan comprising a plurality of individual field of view (FoV) images that form one image when stitched together, each FoV image having a border zone overlapping a border zone of an adjacent FoV image, the plurality of image capture scans corresponding to a plurality of images that are stackable, the system comprising a computing system comprising a stitching and stacking program module installed and executable in the computing system. The stitching and stacking program module is configured to compute a position of each of the FoV images from all image capture scans concomitantly and thereby concomitantly stitch together the individual FoV images and stack said plurality of images.