公开(公告)号：EP3087101A1

公开(公告)日：2016-11-02

申请号：EP14872734.0

申请日：2014-12-19

申请人： Novartis AG ,  The Trustees of The University of Pennsylvania ,  Brogdon, Jennifer ,  Engels, Boris ,  GLASS, David, Jonathan ,  GRANDA, Brian ,  HASTEWELL, John ,  LOEW, Andreas ,  MANNICK, Joan ,  Milone, Michael C. ,  MURPHY, Leon ,  SELLERS, William Raj ,  SONG, Huijuan ,  VASH, Brian Edward ,  WEILER, Jan ,  WU, Qilong ,  ZHOU, Li

发明人： BROGDON, Jennifer ,  ENGELS, Boris ,  GLASS, David Jonathan ,  GRANDA, Brian ,  HASTEWELL, John ,  LOEW, Andreas ,  MANNICK, Joan ,  MILONE, Michael ,  MURPHY, Leon ,  SELLERS,William Raj ,  SONG, Huijuan ,  VASH, Brian Edward ,  WEILER, Jan ,  WU, Qilong ,  ZHOU, Li

IPC分类号： C07K19/00 ,  C12N5/0783

CPC分类号： C07K16/2863 ,  A61K31/436 ,  A61K35/17 ,  C07K14/7051 ,  C07K14/70521 ,  C07K14/70578 ,  C07K14/71 ,  C07K2317/622 ,  C07K2319/00 ,  C07K2319/03 ,  C07K2319/41 ,  C07K2319/43 ,  C07K2319/70 ,  C12N9/1205 ,  C12N9/90 ,  C12Y502/00

摘要： Compositions and methods relating to regulatable chimeric antigen receptors (RCARs), where the intracellular signaling or proliferation of the RCAR can be controlled to optimize the use of an RCAR-expressing cell to provide an immune response, are provided. For example, a RCAR can comprise a dimerization switch that, upon the presence of a dimerization molecule, can couple an intracellular signaling domain to an extracellular recognition element, e.g., an antigen binding domain, an inhibitory counter ligand binding domain, or costimulatory ECD domain. An RCAR can be engineered to include an appropriate antigen binding domain that is specific to a desired antigen target and used in the treatment of a disease.

摘要翻译： 提供了与可调节嵌合抗原受体（RCAR）相关的组合物和方法，其中可以控制RCAR的细胞内信号传导或增殖以优化使用表达RCAR的细胞以提供免疫应答。 例如，RCAR可以包含二聚转换开关，其在存在二聚化分子时可以将细胞内信号转导域偶联到细胞外识别元件，例如抗原结合结构域，抑制性反配体结合结构域或共刺激ECD结构域 。 RCAR可以被设计成包括对所需抗原靶特异性并用于治疗疾病的合适的抗原结合结构域。

公开(公告)号：EP3087101A4

公开(公告)日：2017-12-06

申请号：EP14872734

申请日：2014-12-19

申请人： NOVARTIS AG ,  UNIV PENNSYLVANIA ,  BROGDON JENNIFER ,  ENGELS BORIS ,  GLASS DAVID JONATHAN ,  GRANDA BRIAN ,  HASTEWELL JOHN ,  LOEW ANDREAS ,  MANNICK JOAN ,  MILONE MICHAEL C ,  MURPHY LEON ,  SELLERS WILLIAM RAJ ,  SONG HUIJUAN ,  VASH BRIAN EDWARD ,  WEILER JAN ,  WU QILONG ,  ZHOU LI

发明人： BROGDON JENNIFER ,  ENGELS BORIS ,  GLASS DAVID JONATHAN ,  GRANDA BRIAN ,  HASTEWELL JOHN ,  LOEW ANDREAS ,  MANNICK JOAN ,  MILONE MICHAEL ,  MURPHY LEON ,  SELLERS WILLIAM RAJ ,  SONG HUIJUAN ,  VASH BRIAN EDWARD ,  WEILER JAN ,  WU QILONG ,  ZHOU LI

IPC分类号： C07K19/00 ,  A61K31/436 ,  A61K35/17 ,  C07K14/725 ,  C07K16/28 ,  C12N5/0783

CPC分类号： C07K16/2863 ,  A61K31/436 ,  A61K35/17 ,  C07K14/7051 ,  C07K14/70521 ,  C07K14/70578 ,  C07K14/71 ,  C07K2317/622 ,  C07K2319/00 ,  C07K2319/03 ,  C07K2319/41 ,  C07K2319/43 ,  C07K2319/70 ,  C12N9/1205 ,  C12N9/90 ,  C12Y502/00

摘要： Compositions and methods relating to regulatable chimeric antigen receptors (RCARs), where the intracellular signaling or proliferation of the RCAR can be controlled to optimize the use of an RCAR-expressing cell to provide an immune response, are provided. For example, a RCAR can comprise a dimerization switch that, upon the presence of a dimerization molecule, can couple an intracellular signaling domain to an extracellular recognition element, e.g., an antigen binding domain, an inhibitory counter ligand binding domain, or costimulatory ECD domain. An RCAR can be engineered to include an appropriate antigen binding domain that is specific to a desired antigen target and used in the treatment of a disease.