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公开(公告)号：EP1405560A4
公开(公告)日：2007-09-05
申请号：EP02745959
申请日：2002-07-11
发明人： MIZUTANI HITOSHI
IPC分类号： A01K67/027 , A61P17/00 , A61P37/08 , C12N15/85 , G01N33/68 , A61K45/00 , G01N33/15 , G01N33/50
CPC分类号： C12N15/8509 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/0325 , C12N2830/008 , G01N33/6869 , G01N2500/00
摘要： A transgenic non-human mammal having a DNA transferred in such a manner as to express a foreign IL-18 gene specifically in the skin, or its offspring. This transgenic nonhuman mammal spontaneously suffers from atopic dermatitis in the absence of any specific pathogenic microorganism, which makes it useful as a disease model animal. Use of this transgenic animal makes it possible to develop drugs for preventing and treating atopic dermatitis by natural immunity and to clarify the onset mechanism of atopic dermatitis.
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公开(公告)号：EP1290939B1
公开(公告)日：2006-08-23
申请号：EP01941062.0
申请日：2001-06-15
发明人： MIZUTANI, Hitoshi
CPC分类号： C12N15/8509 , A01K67/0275 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/105 , A01K2267/0325 , C12N9/6475 , C12N2830/008
摘要： A transgenic non-human mammal having a DNA which carries a DNA having a foreign caspase 1 gene integrated thereinto in such a manner as being skin-specifically expressed or its offspring. Because of spontaneously suffering from atopic dermatitis in the absence of any specific pathogenic microorganism, the above transgenic non-human mammal is useful as a disease model animal. Use of the transgenic animal makes it possible to develop preventives and remedies for atopic dermatitis based on natural immunity and to clarify the onset mechanism of atopic diseases.
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公开(公告)号：EP1405560B1
公开(公告)日：2011-10-19
申请号：EP02745959.3
申请日：2002-07-11
发明人： MIZUTANI, Hitoshi
CPC分类号： C12N15/8509 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/0325 , C12N2830/008 , G01N33/6869 , G01N2500/00
摘要： A transgenic non-human mammal having a DNA transferred in such a manner as to express a foreign IL-18 gene specifically in the skin, or its offspring. This transgenic nonhuman mammal spontaneously suffers from atopic dermatitis in the absence of any specific pathogenic microorganism, which makes it useful as a disease model animal. Use of this transgenic animal makes it possible to develop drugs for preventing and treating atopic dermatitis by natural immunity and to clarify the onset mechanism of atopic dermatitis.
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公开(公告)号：EP1405560A1
公开(公告)日：2004-04-07
申请号：EP02745959.3
申请日：2002-07-11
发明人： MIZUTANI, Hitoshi
CPC分类号： C12N15/8509 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/0325 , C12N2830/008 , G01N33/6869 , G01N2500/00
摘要： Transgenic non-human mammals comprising a DNA with an exogenous IL-18 gene incorporated in it such that the exogenous IL-18 gene is skin-specifically expressed, or their offsprings.
The transgenic non-human mammals according to the present invention spontaneously develop atopic dermatitis under specific pathogen-free conditions, and therefore, are useful as disease model animals. Use of the transgenic non-human mammals according to the present invention makes it possible to develop drugs for preventing or treating atopic dermatitis by natural immunity and also to elucidate the onset mechanisms of atopic diseases.摘要翻译： 具有转移以在皮肤中特异性表达外源IL-18基因的DNA或其后代的转基因非人哺乳动物是新的。 还包括以下独立权利要求：（1）通过向动物或其后代施用检测物质并检测症状的改善来筛查特应性皮炎的预防药物或补救措施; （2）用于预防或治疗含有如此筛选的物质的特应性皮炎的药物; （3）通过转移用于整合的DNA来产生动物或其后代，以将外源IL-18基因表达到非人哺乳动物的受精卵中，随后将所得受精卵植入该动物的雌性中。 活动：皮肤病学; 抗炎。 没有给出生物数据。 行动机制：源材料无。
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公开(公告)号：EP1290939A4
公开(公告)日：2003-07-16
申请号：EP01941062
申请日：2001-06-15
发明人： MIZUTANI HITOSHI
CPC分类号： C12N15/8509 , A01K67/0275 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/105 , A01K2267/0325 , C12N9/6475 , C12N2830/008
摘要： A transgenic non-human mammal having a DNA which carries a DNA having a foreign caspase 1 gene integrated thereinto in such a manner as being skin-specifically expressed or its offspring. Because of spontaneously suffering from atopic dermatitis in the absence of any specific pathogenic microorganism, the above transgenic non-human mammal is useful as a disease model animal. Use of the transgenic animal makes it possible to develop preventives and remedies for atopic dermatitis based on natural immunity and to clarify the onset mechanism of atopic diseases.
摘要翻译： 一种转基因非人类哺乳动物，其DNA具有携带外源半胱氨酸蛋白酶1基因的DNA以皮肤特异性表达的方式整合于其中的DNA或其后代。 由于在没有任何特定致病微生物的情况下自发地患有特应性皮炎，所以上述转基因非人类哺乳动物可用作疾病模型动物。 使用转基因动物可以开发基于自然免疫的特应性皮炎的预防和治疗，并阐明特应性疾病的发病机制。
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公开(公告)号：EP1290939A1
公开(公告)日：2003-03-12
申请号：EP01941062.0
申请日：2001-06-15
发明人： MIZUTANI, Hitoshi
IPC分类号： A01K67/027 , A61K45/00 , A61P37/08 , A61P17/00 , C12N15/57
CPC分类号： C12N15/8509 , A01K67/0275 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/105 , A01K2267/0325 , C12N9/6475 , C12N2830/008
摘要： A transgenic non-human mammal or its offspring which carries DNA having exogenous caspase 1 gene integrated thereinto in such a manner as to express the gene specifically to skin.
In view that the transgenic non-human mammal of the present invention spontaneously develops atopic dermatitis in the absence of any specific pathogenic microorganism, the mammal is useful as a disease model animal. Use of the transgenic animal of the present invention enables development of preventive and/or therapeutic drugs for atopic dermatitis based on natural immunity and to clarify the onset mechanism of atopic diseases.摘要翻译： 转基因非人类哺乳动物或其后代，其携带具有外源半胱天冬酶1基因的DNA，以特异性表达该皮肤基因的方式。 鉴于本发明的转基因非人哺乳动物在没有任何特异性致病微生物的情况下自发发生特应性皮炎，所以哺乳动物可用作疾病模型动物。 使用本发明的转基因动物能够基于天然免疫发展用于特应性皮炎的预防和/或治疗药物，并且阐明特应性疾病的发病机制。
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