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    Method for the preparation of improved mutant strain of bordetella bronchiseptica and live attenuated vaccine containing it
    2.
    发明公开
    Method for the preparation of improved mutant strain of bordetella bronchiseptica and live attenuated vaccine containing it 失效
    一种用于制备支气管炎博德特氏菌的改良突变菌株和那些含有减毒活疫苗的方法。

    公开(公告)号：EP0072656A1

    公开(公告)日：1983-02-23

    申请号：EP82304185.0

    申请日：1982-08-09

    申请人： Juridical Foundation The Chemo-Sero-Therapeutic Research Institute ,  NIPPON VACCINE CO. LTD. ,  Shimizu, Takeshi

    发明人： Shimizu, Takeshi

    IPC分类号： A61K39/10 ,  C12N15/00

    CPC分类号： C12N15/01 ,  A61K39/099 ,  A61K2039/522 ,  Y10S424/825 ,  Y10S424/83

    摘要： new mutant strain of Bordetella bronchiseptica is prepared by applying a mutagen to a strain of B. bronchiseptica to obtain a mutant strain having hereditary markers of at least temperature-sensivity and urease negative (ts-34.u) and subjecting the resulting phase III organism to repeated culturing on a blood agar medium, each time picking up a cell grown with a comparatively small colony, to obtain a phase I organism which has completely capsular antigen and is hemolytic. This strain has excellent immunogenicity and high safety, and is useful for preparation of a live attenuated vaccine for prophylaxis of B. bronchiseptica infection.

    摘要翻译： 支气管炎博德特氏菌的一个新突变菌株是通过将诱变剂支气管炎博德特氏菌的菌株，以获得具有至少温度sensivity和尿素酶阴性（TS 34.u）的遗传标志物的突变菌株，和使所得到的相制备的 III生物体的血液琼脂培养基上培养重复，每次拾取具有相对小的集落生长的细胞，以获得相我有机体具有完全呼叫荚膜抗原和溶血。 该菌株具有良好的免疫原性和高安全性，并且是用于制备减毒活疫苗对支气管败血感染预防是有用的。