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公开(公告)号：EP3132034A1
公开(公告)日：2017-02-22
申请号：EP15718982.0
申请日：2015-04-14
IPC分类号： C12N15/09
摘要： The invention encompasses recombinant polynucleotides, compositions and methods for interfering with antibiotic resistance genes, and/or replicons carrying such genes, in microorganisms in order to disable antibiotic resistance in the microorganisms, using a clustered regularly interspaced short palindromic repeat (CRISPR) array system.
摘要翻译： 本发明包括用微生物干扰抗生素抗性基因和/或携带这些基因的复制子的重组多核苷酸，组合物和方法，以便使用聚集的规则间隔的短回文重复（CRISPR）阵列系统来抑制微生物中的抗生素抗性。
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公开(公告)号：EP3766971A1
公开(公告)日：2021-01-20
申请号：EP20190714.4
申请日：2015-04-14
IPC分类号： C12N15/09
摘要： The invention encompasses recombinant polynucleotides, compositions and methods for interfering with antibiotic resistance genes, and/or replicons carrying such genes, in microorganisms in order to disable antibiotic resistance in the microorganisms, using a clustered regularly interspaced short palindromic repeat (CRISPR) array system.
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公开(公告)号：EP3334445A1
公开(公告)日：2018-06-20
申请号：EP16753448.6
申请日：2016-08-12
CPC分类号： A61K35/76
摘要： The invention relates in one aspect to a pharmaceutical composition comprising a nucleic acid delivery vehicle for delivering a deliverable nucleic acid into a bacterial cell, wherein the delivery vehicle comprises a deliverable nucleic acid packaged into one or more bacteriophage coat proteins, and wherein the delivery vehicle is capable of infecting the bacterial cell to introduce the deliverable nucleic acid into the cell, following which the deliverable nucleic acid is capable of forming a plasmid in the cell and being transmitted to one or more different bacterial cells by conjugation and not by infection. Compositions including a pharmaceutical composition comprising the delivery vehicle, and methods involving use or manufacture of the delivery vehicle, are also disclosed.
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