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11 条记录 (耗时 0.014 秒)

    T cell antigen receptor peptides
    1.
    发明公开
    T cell antigen receptor peptides 失效
    T-Zellenantigen-Rezeptorpeptide

    公开(公告)号：EP2009018A2

    公开(公告)日：2008-12-31

    申请号：EP08016052.6

    申请日：1997-06-11

    申请人： Northern Sydney and Central Coast Area Health Service

    发明人： Manolios, Nicholas

    IPC分类号： C07K4/00 ,  C07K7/04 ,  C07K14/00 ,  C07K14/705 ,  C07K7/06 ,  A61K38/08 ,  A61K38/03 ,  A61K38/16 ,  A61K38/17 ,  A61K47/48

    CPC分类号： C07K14/7051 ,  A61K38/00

    摘要： The present invention provides peptides which affect T cells, presumably by action on the T-cell antigen receptors. The present invention further relates to the therapy of various inflammatory and autoimmune disease states involving the use of these peptides. Specifically the peptides are useful in the treatment of disorders where T-cells are involved or recruited. In one aspect the peptides have the formula R1-A-B-A-R2 in which A is a hydrophobic amino acid or a hydrophobic peptide sequence comprising between 2 and 10 amino acids; B is a charged amino acid; R1 is NH2 and R2 is COOH. In another aspect the peptides have the formula R1-A B-C-R2 in which A is a peptide sequence of between 0 and 5 amino acids; B is cysteine; C is a peptide sequence of between 2 to 10 amino acids; R1 is NH2 and R2 is COOH.

    摘要翻译： 本发明提供了可能通过对T细胞抗原受体的作用影响T细胞的肽。 本发明还涉及涉及使用这些肽的各种炎性和自身免疫性疾病的治疗。 具体地说，该肽可用于治疗涉及或招募T细胞的疾病。 在一个方面，肽具有式R1-A-B-A-R2，其中A是疏水性氨基酸或包含2至10个氨基酸的疏水性肽序列; B是带电荷的氨基酸; R1是NH2，R2是COOH。 在另一方面，肽具有式R 1 -A A B-C-R 2，其中A是0至5个氨基酸的肽序列; B是半胱氨酸; C是2至10个氨基酸的肽序列; R1是NH2，R2是COOH。

    T cell antigen receptor peptides
    9.
    发明公开
    T cell antigen receptor peptides 失效
    T细胞抗原Rezeptopeptide

    公开(公告)号：EP2009018A3

    公开(公告)日：2009-03-18

    申请号：EP08016052.6

    申请日：1997-06-11

    申请人： Northern Sydney and Central Coast Area Health Service

    发明人： Manolios, Nicholas

    IPC分类号： C07K4/00 ,  C07K7/04 ,  C07K14/00 ,  C07K14/705 ,  C07K7/06 ,  A61K38/08 ,  A61K38/03 ,  A61K38/16 ,  A61K38/17 ,  A61K47/48

    CPC分类号： C07K14/7051 ,  A61K38/00

    摘要： The present invention provides peptides which affect T cells, presumably by action on the T-cell antigen receptors. The present invention further relates to the therapy of various inflammatory and autoimmune disease states involving the use of these peptides. Specifically the peptides are useful in the treatment of disorders where T-cells are involved or recruited. In one aspect the peptides have the formula R1-A-B-A-R2 in which A is a hydrophobic amino acid or a hydrophobic peptide sequence comprising between 2 and 10 amino acids; B is a charged amino acid; R1 is NH2 and R2 is COOH. In another aspect the peptides have the formula R1-A B-C-R2 in which A is a peptide sequence of between 0 and 5 amino acids; B is cysteine; C is a peptide sequence of between 2 to 10 amino acids; R1 is NH2 and R2 is COOH.

    Methods of assessing embryo viability
    10.
    发明公开
    Methods of assessing embryo viability 有权
    Verfahren zur Beurteilung derLebensfähigkeitvon Embryos

    公开(公告)号：EP1847595A1

    公开(公告)日：2007-10-24

    申请号：EP07251672.7

    申请日：2007-04-20

    申请人： Northern Sydney and Central Coast Area Health Service

    发明人： O'Neill, Christopher

    IPC分类号： C12N5/06 ,  G01N33/68

    CPC分类号： G01N33/689 ,  C12N5/0604

    摘要： Methods for determining the viability of an embryo or an embryo precursor, comprising measuring the level of a polypeptide or peptide released by a cultured embryo or embryo precursor into the culture medium are disclosed. The polypeptide may be p53. Also disclosed are methods of ranking embryos on the basis of their viability using such methods. Methods for screening for agents which modulate embryo viability, as measured by changes in the level of a polypeptide marker released by a cultured embryo or embryo precursor are also described.

    摘要翻译： 公开了用于测定胚胎或胚胎前体的存活力的方法，包括测量培养的胚胎或胚胎前体释放到培养基中的多肽或肽的水平。 多肽可以是p53。 还公开了使用这些方法基于其生存力对胚胎进行分级的方法。 还描述了通过培养的胚胎或胚胎前体释放的多肽标记物水平的变化来测量调节胚胎存活力的试剂的方法。